21世纪以来全球手足口病研究的文献计量分析

Bibliometric Analysis of Global Hand, Foot, and Mouth Disease Research since the 21st Century

摘要: 目的：分析21世纪以来全球手足口病的研究现状，客观反映国内外研究手足口病的发展动态与未来趋势。方法：在中国知网、Web of science核心合集数据库中以“手足口病”、“手口足综合征”、“HFMD”为主题检索词，对2000年1月1日~2024年12月31日数据库收录的手足口病研究文献进行检索，采用CiteSpace软件对检索结果进行文献计量分析。结果：2000~2024年全球手足口病相关研究发文量整体呈上升趋势，但CNKI数据库发文量呈现先快速增长后下降趋势，而WOS数据库发文量呈逐渐增长并保持平稳态势。在作者与机构层面，中国机构在全球手足口病研究领域占据主要地位，美国、英国其次。关键词分析显示，国内外研究热点各有侧重，国外研究主要聚焦病毒本身及相关生物学机制，国内研究侧重临床治疗与护理等方面。突现性分析与时间线图分析表明，手足口病研究早期关注疾病特征与病原体，后逐渐转向流行病学、环境因素及疾病影响因素等。结论：未来研究应进一步探讨环境因素对手足口病的影响，并加强国际合作，以应对这一全球性公共卫生挑战。

Abstract: Objective: To analyze the current status of global hand, foot, and mouth disease (HFMD) research since the 2000s and objectively reflect the dynamic development and future trends of HFMD research across domestic and international contexts. Methods: Using “hand, foot, and mouth disease”, “hand-mouth-foot syndrome”, and “HFMD” as subject search terms, we retrieved literature from the China National Knowledge Infrastructure (CNKI) and Web of Science Core Collection databases for the period January 1, 2000, to December 31, 2024. Bibliometric analysis was performed using CiteSpace software to visualize and interpret the data. Results: Global HFMD-related publications from 2000 to 2024 showed an overall upward trend. Notably, CNKI publications exhibited rapid initial growth followed by a decline, while WOS publications increased gradually and stabilized. At both the author and institutional levels, Chinese institutions dominate the global research landscape on hand, foot and mouth disease, followed by those in the United States and the United Kingdom. Keyword analysis reveals that domestic and international research priorities diverge: overseas studies concentrate on the virus itself and its underlying biological mechanisms, whereas Chinese research emphasizes clinical treatment and nursing care. Burst-detection and timeline analyses show that early HFMD investigations focused on disease characteristics and the causative pathogen, then gradually shifted toward epidemiology, environmental determinants, and other influencing factors. Conclusion: Future work should more deeply probe the environmental drivers of HFMD and strengthen international collaboration to meet this pressing global public-health challenge.