针刺疗法调节GABA能系统改善失眠的研究进展

Research Progress on Acupuncture Therapy Regulating GABAergic System to Improve Insomnia

摘要: 全文通过阐述针刺调节GABA能系统改善失眠作用的机制，说明了失眠是由于GABA能系统出现功能障碍所致；通过对现有相关文献的研究可知，针刺可引起失眠患者脑内γ-氨基丁酸(GABA)含量的变化，并参与调节GABA与谷氨酸(Glu)间的平衡，而GABA与Glu水平之间的失衡可能会影响人的睡眠情况，再者有研究证实GABA可通过激活五羟色胺(5-HT)等途径改善睡眠状态，故可推测针刺疗法可能是通过调节GABA能系统来改善睡眠。目前已有关于通过针刺调控GABA能通路方面的研究表明，针刺对GABA能通路中受体的影响、转运体和代谢酶的影响，其均属于GABA能系统的多靶点调控机制，该类机制为临床上针刺治疗失眠提供了科学依据。

Abstract: The full text elaborates on the mechanism by which acupuncture regulates the GABAergic system to improve insomnia, and explains that insomnia is caused by dysfunction of the GABAergic nervous system; Through research on existing relevant literature, it is known that acupuncture can cause changes in the levels of gamma aminobutyric acid (GABA) in the brains of insomnia patients and participate in regulating the balance between GABA and glutamate (Glu). The imbalance between GABA and Glu levels may affect human sleep. Furthermore, studies have shown that GABA can improve sleep status by activating serotonin (5-HT) and other pathways. Therefore, it can be speculated that acupuncture therapy may improve sleep by regulating the GABAergic system. At present, research on regulating the GABAergic pathway through acupuncture has shown that the effects of acupuncture on receptors, transporters, and metabolic enzymes in the GABAergic pathway belong to the multi-target regulatory mechanism of the GABAergic system, which provides scientific basis for acupuncture treatment of insomnia in clinical practice.