基于MB/PPy/COFs纳米复合材料构建超灵敏电化学生物传感器用于尿酸检测

An Ultra-Sensitive Electrochemical Biosensor Was Constructed Based on MB/PPy/COFs Nanocomposites for Uric Acid Detection

摘要: 基于亚甲基蓝(MB)、聚吡咯(PPy)和COFs构建了一种具有高选择性和高灵敏度的新型电化学生物传感器用于检测尿酸(UA)。该电化学生物传感器无需其他外在电化学信号物可直接产生电化学响应信号。实验结果表明，该传感器的氧化峰电流与UA浓度的对数呈现良好线性关系，检测范围为10 ng/mL~10000 ng/mL，检测限为2 ng/mL。此外，构建传感器的基底材料间具有良好的协同作用，MB的电子传递、PPy的导电性和COFs的孔道与比表面积优势三者的功能互补，显著提升电催化效率，为UA的快速、灵敏检测提供了新型传感平台。该研究拓展了COFs基纳米复合材料在生物医学检测中的应用，有望助力临床诊断和健康监测。

Abstract: A novel electrochemical biosensor with high selectivity and high sensitivity was constructed based on methylene blue (MB), polypyrrole (PPy) and COFs for the detection of uric acid (UA). This electrochemical biosensor can directly generate electrochemical response signals without the need for other external electrochemical signal substances. Experimental analysis shows that the oxidation peak current of this sensor presents a good linear relationship with the logarithm of UA concentration. The detection range is 10 ng/mL~10,000 ng/mL, and the detection limit is 2 ng/mL. In addition, this sensor also has a good material synergy. The complementary functions of the electron transfer of MB, the conductivity of PPy, and the pore and specific surface area advantages of COFs significantly enhance the electrocatalytic efficiency, providing a new sensing platform for the rapid and sensitive detection of UA. This research expands the application of CoFs-based nanocomposites in biomedical detection and is expected to contribute to clinical diagnosis and health monitoring.