术中手持显微镜技术在乳腺癌手术中切缘判断的应用

The Application of Intraoperative Handheld Microscope Technology in Breast Cancer Surgery for Margin Assessment

摘要: 目的：介绍一种新的在手术中判断乳腺癌手术切缘状态的方法，初步探讨术中手持细胞级显微镜技术在乳腺癌手术中判断肿瘤切缘的可行性。方法：回顾性分析我科2024年7月迄今完成的采用术中手持显微镜判断乳腺癌切缘的3例典型病例，比较其与术中快速切片及术后石蜡病理的结果，并分析患者临床资料及术后随访情况。结果：患者术中手持显微镜判断切缘的结果与术中冰冻及术后病理结果均相符合。结论：“术中手持显微镜判断乳腺癌手术切缘”在保乳手术、保留乳头乳晕乳腺癌手术、乳腺癌根治术等乳腺癌手术中均具有较好的应用前景。

Abstract: Objective: To introduce a new method for judging the surgical margin status of breast cancer during surgery and to preliminarily explore the feasibility of handheld cell-level microscopy technology in judging tumor margins during breast cancer surgery. Methods: Three typical cases of breast cancer resection margin using intraoperative handheld microscope completed by our department from July 2024 to the present were retrospectively analyzed, and the results of intraoperative rapid sectioning and postoperative paraffin pathology were compared, and the clinical data and postoperative follow-up of patients were analyzed. Results: The results of the patient’s intraoperative handheld microscope to determine the resection margin were consistent with the intraoperative freezing and postoperative pathological results. Conclusion: “Intraoperative handheld microscope to determine the surgical margins of breast cancer” has a good application prospect in breast cancer surgery, such as breast-conserving surgery, nipple-preserving areola breast cancer surgery, and radical mastectomy.