血管内皮生长因子在恶性肿瘤中的研究进展

Research Progress of Vascular Endothelial Growth Factor in Malignant Tumors

摘要: 随着人们生活方式和饮食结构的改变以及人口老龄化的日益加剧，全球各个国家和地区中，恶性肿瘤都是重要的死亡原因。恶性肿瘤的发生、发展和转移离不开新生血管的生成为其提供养分和氧气。大量研究表明，血管的形成与血管内皮生长因子(Vascular Endothelial Growth Factor, VEGF)有着密切的相关，且VEGF是最强的促血管生成因子，在血管及淋巴管内皮细胞的生成中起重要的作用。近年来，在精准医疗的背景下，对恶性肿瘤的靶向治疗已成为众多科研工作者的研究热点，针对VEGF及其受体的靶向药物也是热点之一，已取得一定的进展及临床疗效。

Abstract: With the change of people’s lifestyle and diet structure and the increasing aging of the population, malignant tumors are an important cause of death in various countries and regions around the world. The occurrence, development and metastasis of malignant tumors are inseparable from the formation of new blood vessels, which provide nutrients and oxygen. A large number of studies have shown that the formation of blood vessels is closely related to Vascular Endothelial Growth Factor (VEGF), and VEGF is the strongest pro-angiogenic factor, playing an important role in the formation of blood vessels and lymphatic endothelial cells. In recent years, in the context of precision medicine, the targeted treatment of malignant tumors has become a research hotspot for many researchers, and the targeted drugs targeting VEGF and its receptors are also one of the hot spots, and certain progress and clinical efficacy have been achieved.