子宫内膜癌继发骨转移1例报告并文献复习
A Case Report of Endometrial Carcinoma with Secondary Bone Metastasis and Literature Review
DOI: 10.12677/acm.2025.1582302, PDF,   
作者: 杨 欣, 刘翔宇, 黄利英, 杨 晶, 乔 涵, 李 静, 蒋 丽, 张晶晶*：青岛大学附属医院崂山院区妇科，山东 青岛
关键词: 子宫内膜癌；骨转移；Endometrial Carcinoma； Bone Metastasis
摘要: 子宫内膜癌是最常见的女性生殖系统恶性肿瘤之一，其主要的转移方式为直接蔓延和淋巴结转移，远处转移较少见。子宫内膜癌骨转移在临床上极少见，发生骨转移，常提示预后不良，积极治疗骨转移可在一定程度上延长患者的生存时间。本文对子宫内膜癌骨转移的发生率、诊断及治疗、预后及相关影响因素进行分析，并复习相关文献，为临床诊疗提供帮助。
Abstract: Endometrial carcinoma is one of the most common malignant tumors of the female reproductive system. Its main modes of metastasis are direct spread and lymph node metastasis, while distant metastasis is relatively rare. Bone metastasis of endometrial carcinoma is extremely rare in clinical practice. The occurrence of bone metastasis often indicates a poor prognosis. Active treatment of bone metastasis can, to a certain extent, prolong the survival time of patients. This article analyzes the incidence, diagnosis and treatment, prognosis, and related influencing factors of bone metastasis of endometrial carcinoma, and reviews relevant literature to provide assistance for clinical diagnosis and treatment.
文章引用：杨欣, 刘翔宇, 黄利英, 杨晶, 乔涵, 李静, 蒋丽, 张晶晶. 子宫内膜癌继发骨转移1例报告并文献复习[J]. 临床医学进展, 2025, 15(8): 816-820. https://doi.org/10.12677/acm.2025.1582302

参考文献

[1] Takeshita, S., Todo, Y., Matsumiya, H., Okamoto, K., Yamashiro, K. and Kato, H. (2016) A Prediction Model of Survival for Patients with Bone Metastasis from Uterine Corpus Cancer. Japanese Journal of Clinical Oncology, 46, 973-978. [Google Scholar] [CrossRef] [PubMed]
[2] Uccella, S., Morris, J.M., Bakkum-Gamez, J.N., Keeney, G.L., Podratz, K.C. and Mariani, A. (2013) Bone Metastases in Endometrial Cancer: Report on 19 Patients and Review of the Medical Literature. Gynecologic Oncology, 130, 474-482. [Google Scholar] [CrossRef] [PubMed]
[3] Yoon, A., Choi, C.H., Kim, T., Choi, J., Park, J., Lee, Y., et al. (2014) Bone Metastasis in Primary Endometrial Carcinoma Features, Outcomes, and Predictors. International Journal of Gynecological Cancer, 24, 107-112. [Google Scholar] [CrossRef] [PubMed]
[4] Kurra, V., Krajewski, K.M., Jagannathan, J., Giardino, A., Berlin, S. and Ramaiya, N. (2013) Typical and Atypical Metastatic Sites of Recurrent Endometrial Carcinoma. Cancer Imaging, 13, 113-122. [Google Scholar] [CrossRef] [PubMed]
[5] Nguyen, M.T., LaFargue, C.J., Pua, T.L. and Tedjarati, S.S. (2013) Grade 1 Endometrioid Endometrial Carcinoma Presenting with Pelvic Bone Metastasis: A Case Report and Review of the Literature. Case Reports in Obstetrics and Gynecology, 2013, Article ID: 807205. [Google Scholar] [CrossRef] [PubMed]
[6] Makris, G., Mene, J., Battista, M., Chrelias, G., Sergentanis, T.N., Psyrri, A., et al. (2018) Endometrial Carcinoma with Tibial Bone Metastasis: A Case Report and Literature Review. Journal of Obstetrics and Gynaecology, 38, 1039-1047. [Google Scholar] [CrossRef] [PubMed]
[7] 蒋芳, 任彤, 成宁海, 等. 子宫内膜癌骨转移的临床病理特点及预后分析[J]. 中华妇产科杂志, 2019, 54(7): 452-457.
[8] McEachron, J., Chatterton, C., Hastings, V., Gorelick, C., Economos, K., Lee, Y., et al. (2020) A Clinicopathologic Study of Endometrial Cancer Metastatic to Bone: Identification of Microsatellite Instability Improves Treatment Strategies. Gynecologic Oncology Reports, 32, Article ID: 100549. [Google Scholar] [CrossRef] [PubMed]
[9] 李岚, 代佩灵, 吴星娆, 等. 宫颈癌骨转移的研究进展[J]. 肿瘤, 2021, 41(1): 57-64.
[10] Miller, D.S., Filiaci, V.L., Mannel, R.S., Cohn, D.E., Matsumoto, T., Tewari, K.S., et al. (2020) Carboplatin and Paclitaxel for Advanced Endometrial Cancer: Final Overall Survival and Adverse Event Analysis of a Phase III Trial (NRG Oncology/GOG0209). Journal of Clinical Oncology, 38, 3841-3850. [Google Scholar] [CrossRef] [PubMed]
[11] Wei, W., Ban, X., Yang, F., Li, J., Cheng, X., Zhang, R., et al. (2022) Phase II Trial of Efficacy, Safety and Biomarker Analysis of Sintilimab Plus Anlotinib for Patients with Recurrent or Advanced Endometrial Cancer. Journal for ImmunoTherapy of Cancer, 10, e004338. [Google Scholar] [CrossRef] [PubMed]
[12] Eskander, R.N., Sill, M.W., Beffa, L., Moore, R.G., Hope, J.M., Musa, F.B., et al. (2023) Pembrolizumab Plus Chemotherapy in Advanced Endometrial Cancer. New England Journal of Medicine, 388, 2159-2170. [Google Scholar] [CrossRef] [PubMed]
[13] Myriokefalitaki, E., D’Costa, D., Smith, M. and Ahmed, A.S. (2013) Primary Bone Metastasis as Initial Presentation of Endometrial Cancer (Stage IVb). Archives of Gynecology and Obstetrics, 288, 739-746. [Google Scholar] [CrossRef] [PubMed]
[14] Doğer, E., Çakiroğlu, Y., Özdamar, Ö., Ceylan, Y., Köle, E., Yücesoy, I. and Çaliskan, E. (2016) Bone Metastasis in Endometrial Cancer: Evaluation of Treatment Approaches by Factors Affecting Prognosis. European Journal of Gynaecological Oncology, 37, 407-416.

为你推荐