人工智能在脂肪性肝病图像诊断中的研究进展
Research Progress of Artificial Intelligence in Image Diagnosis of Fatty Liver Disease
DOI: 10.12677/acm.2025.1582303, PDF,    科研立项经费支持
作者: 吕宇睿, 张梦维:绍兴文理学院医学院,浙江 绍兴;赵振华, 杨建峰, 赵 丽*:绍兴市人民医院(绍兴文理学院附属第一医院)放射科,浙江 绍兴
关键词: 人工智能脂肪性肝病图像诊断Artificial Intelligence Fatty Liver Disease Image Diagnosis
摘要: 人工智能(AI)的理论和技术日益成熟,其在医疗领域的应用不断扩大,特别是在处理图像方面的应用发展最快。脂肪性肝病发病率高,发病年龄日趋年轻化。脂肪性肝病早期的精准筛查、分类、定性定量诊断,以及进展情况的准确判读等对患者的预防、治疗有重要的意义。本文对AI在超声、CT、MRI、病理图像上对脂肪性肝病诊断的研究进展进行综述。
Abstract: The theory and technology of Artificial Intelligence (AI) are becoming increasingly mature, and its application in the medical field is expanding, especially in the field of image processing. The incidence of fatty liver disease is high, and the age of onset is becoming younger. Accurate screening, classification, qualitative and quantitative diagnosis of fatty liver in the early stage, as well as accurate judgment of the progress of the disease, are of great significance for the prevention and treatment of patients. This article reviews the research progress of AI in the diagnosis of fatty liver disease on ultrasound, CT, MRI, and pathological images.
文章引用:吕宇睿, 张梦维, 赵振华, 杨建峰, 赵丽. 人工智能在脂肪性肝病图像诊断中的研究进展[J]. 临床医学进展, 2025, 15(8): 821-826. https://doi.org/10.12677/acm.2025.1582303

参考文献

[1] Stajic, J., Stone, R., Chin, G. and Wible, B. (2015) Rise of the Machines. Science, 349, 248-249. [Google Scholar] [CrossRef] [PubMed]
[2] Rajpurkar, P., Chen, E., Banerjee, O. and Topol, E.J. (2022) AI in Health and Medicine. Nature Medicine, 28, 31-38. [Google Scholar] [CrossRef] [PubMed]
[3] Kiarash, R., Hassan, A., Jacob, H.C., et al. (2022) The Prevalence and Incidence of NAFLD Worldwide: A Systematic Review and Meta-Analysis. The Lancet Gastroenterology & Hepatology, 7, 851-861.
[4] De Minicis, S., Day, C. and Svegliati-Baroni, G. (2013) From NAFLD to NASH and HCC: Pathogenetic Mechanisms and Therapeutic Insights. Current Pharmaceutical Design, 19, 5239-5249. [Google Scholar] [CrossRef] [PubMed]
[5] Wang, S. and Summers, R.M. (2012) Machine Learning and Radiology. Medical Image Analysis, 16, 933-951. [Google Scholar] [CrossRef] [PubMed]
[6] 夏明锋, 高鑫. 无创性诊断非酒精性脂肪性肝病的方法学进展[J]. 中华内分泌代谢杂志, 2010, 26(7): 623-626.
[7] Han, A., Byra, M., Heba, E., Andre, M.P., Erdman, J.W., Loomba, R., et al. (2020) Noninvasive Diagnosis of Nonalcoholic Fatty Liver Disease and Quantification of Liver Fat with Radiofrequency Ultrasound Data Using One-Dimensional Convolutional Neural Networks. Radiology, 295, 342-350. [Google Scholar] [CrossRef] [PubMed]
[8] Yang, Y., Liu, J., Sun, C., Shi, Y., Hsing, J.C., Kamya, A., et al. (2023) Nonalcoholic Fatty Liver Disease (NAFLD) Detection and Deep Learning in a Chinese Community-Based Population. European Radiology, 33, 5894-5906. [Google Scholar] [CrossRef] [PubMed]
[9] Zhu, H., Liu, Y., Gao, X. and Zhang, L. (2022) Combined CNN and Pixel Feature Image for Fatty Liver Ultrasound Image Classification. Computational and Mathematical Methods in Medicine, 2022, 1-10. [Google Scholar] [CrossRef] [PubMed]
[10] Graffy, P.M., Sandfort, V., Summers, R.M. and Pickhardt, P.J. (2019) Automated Liver Fat Quantification at Nonenhanced Abdominal CT for Population-Based Steatosis Assessment. Radiology, 293, 334-342. [Google Scholar] [CrossRef] [PubMed]
[11] Huo, Y., Terry, J.G., Wang, J., Nair, S., Lasko, T.A., Freedman, B.I., et al. (2019) Fully Automatic Liver Attenuation Estimation Combing CNN Segmentation and Morphological Operations. Medical Physics, 46, 3508-3519. [Google Scholar] [CrossRef] [PubMed]
[12] Lin, H., Xu, X., Deng, R., Xu, Z., Cai, X., Dong, H., et al. (2024) Photon-Counting Detector CT for Liver Fat Quantification: Validation across Protocols in Metabolic Dysfunction-Associated Steatotic Liver Disease. Radiology, 312, e240038. [Google Scholar] [CrossRef] [PubMed]
[13] Chen, X.X., Wang, X.M., Zhang, K., et al. (2022) Recent Advances and Clinical Applications of Deep Learning in Medical Image Analysis. Medical Image Analysis, 79, Article ID: 102444. [Google Scholar] [CrossRef] [PubMed]
[14] Castera, L., Friedrich-Rust, M. and Loomba, R. (2019) Noninvasive Assessment of Liver Disease in Patients with Nonalcoholic Fatty Liver Disease. Gastroenterology, 156, 1264-1281. [Google Scholar] [CrossRef] [PubMed]
[15] Qu, Y., Li, M., Hamilton, G., Zhang, Y.N. and Song, B. (2019) Diagnostic Accuracy of Hepatic Proton Density Fat Fraction Measured by Magnetic Resonance Imaging for the Evaluation of Liver Steatosis with Histology as Reference Standard: A Meta-Analysis. European Radiology, 29, 5180-5189. [Google Scholar] [CrossRef] [PubMed]
[16] Davison, B.A., Harrison, S.A., Cotter, G., Alkhouri, N., Sanyal, A., Edwards, C., et al. (2020) Suboptimal Reliability of Liver Biopsy Evaluation Has Implications for Randomized Clinical Trials. Journal of Hepatology, 73, 1322-1332. [Google Scholar] [CrossRef] [PubMed]
[17] Nam, D., Chapiro, J., Paradis, V., Seraphin, T.P. and Kather, J.N. (2022) Artificial Intelligence in Liver Diseases: Improving Diagnostics, Prognostics and Response Prediction. JHEP Reports, 4, Article ID: 100443. [Google Scholar] [CrossRef] [PubMed]
[18] Ratziu, V., Hompesch, M., Petitjean, M., et al. (2023) Artificial Intelligence-Assisted Digital Pathology for Non-Alcoholic Steatohepatitis: Current Status and Future Directions. Journal of Hepatology, 80, 335-351.
[19] Munsterman, I.D., van Erp, M., Weijers, G., Bronkhorst, C., de Korte, C.L., Drenth, J.P.H., et al. (2019) A Novel Automatic Digital Algorithm That Accurately Quantifies Steatosis in NAFLD on Histopathological Whole‐Slide Images. Cytometry Part B: Clinical Cytometry, 96, 521-528. [Google Scholar] [CrossRef] [PubMed]