慢性阻塞性肺疾病频繁急性加重生物标志物的研究进展
Research Progress on Biomarkers of Frequent Acute Exacerbations of Chronic Obstructive Pulmonary Disease
DOI: 10.12677/acm.2025.1582305, PDF,   
作者: 向竹艳：吉首大学医学院，湖南 吉首；梁民勇*：吉首大学第一附属医院呼吸内科，湖南 吉首；周卫华：吉首大学第一附属医院产前诊断中心，湖南 吉首
关键词: 慢性阻塞性肺疾病急性加重；慢性阻塞性肺疾病频繁急性加重；生物标志物；Acute Exacerbation of Chronic Obstructive Pulmonary Disease； Frequent Acute Exacerbations of Chronic Obstructive Pulmonary Disease； Biomarkers
摘要: 慢性阻塞性肺疾病(简称慢阻肺)是一种常见的慢性气道炎症性疾病。其急性加重是病程中的重要事件，可导致肺功能快速下降并增加死亡风险。越来越多的研究表明“频繁急性加重”表型的重要性，该表型预示着更严重的气流受限、更明显的症状、更差的生活质量以及更高的死亡率。然而，关于这一表型的识别及治疗仍缺乏共识，本综述围绕该表型对其生物标志物进行探讨，为临床工作者对该表型患者的识别及个体化治疗提供理论依据。
Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a common chronic inflammatory disease of the airways. An exacerbation is an important event in the course of the disease and can lead to a rapid decline in lung function and an increased risk of death. A growing body of research has shown the importance of the “frequent acute exacerbations” phenotype, which predicts more severe airflow limitation, more pronounced symptoms, worse quality of life, and higher mortality. However, there is still a lack of consensus on the identification and treatment of this phenotype, and this review explores its (potential) biomarkers around this phenotype, so as to provide a theoretical basis for clinicians to identify and individualize the treatment of patients with this phenotype.
文章引用：向竹艳, 梁民勇, 周卫华. 慢性阻塞性肺疾病频繁急性加重生物标志物的研究进展[J]. 临床医学进展, 2025, 15(8): 833-841. https://doi.org/10.12677/acm.2025.1582305

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