早发性卵巢功能不全的病因研究进展
Research Progress on the Etiology of Premature Ovarian Insufficiency
DOI: 10.12677/md.2025.154051, PDF,   
作者: 吴 琼：延安大学医学院，陕西 延安；岳红云*：延安大学附属医院妇产科，陕西 延安
关键词: 早发性卵巢功能不全；病因；不孕症；Premature Ovarian Insufficiency； Etiology； Infertility
摘要: 本综述旨在探讨近年来早发性卵巢功能不全的病因进展。早发性卵巢功能不全(Premature ovarian insufficiency, POI)是指女性在40岁之前出现卵巢功能的减退。POI的病因包括遗传因素、自身免疫因素、手术、放化疗因素、社会心理、生活方式和环境因素、感染因素等。POI女性的卵母细胞储备提前耗竭，影响卵泡的发育和排卵，导致POI的女性生育力下降或不孕。本研究通过系统回顾相关文献，对POI的病因进行总结，对导致POI的高危因素进行有效的干预和预防，提前保护卵巢功能和保存生育力，同时对POI的治疗提供有效的策略，降低POI的发病率。
Abstract: This review aims to explore the etiological progress of premature ovarian insufficiency in recent years. Premature ovarian insufficiency refers to the decline of ovarian function before the age of 40 in women. The etiology of POI includes genetic factors, autoimmune factors, surgery radiotherapy and chemotherapy factors, sociodemographic, lifestyle and environmental factors, infectious factors and so on. The premature exhaustion of oocytes reserve in POI women affects the development ovulation of follicles, resulting in the decrease of fertility or infertility in POI women. This study summarized the etiology of POI by systematic review of relevant literature carried out effective intervention and prevention to the high risk factors leading to POI, and protected ovarian function and preserved fertility in advance, while also providing effective strategies for the treatment POI and reducing the incidence of POI.
文章引用：吴琼, 岳红云. 早发性卵巢功能不全的病因研究进展[J]. 医学诊断, 2025, 15(4): 375-383. https://doi.org/10.12677/md.2025.154051

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