甲苯磺酸瑞马唑仑联合富马酸奥赛利定在无痛胃肠镜中的应用：机制、疗效与安全性
Application of Remimazolam Tosylate Combined with Oxeridine Fumarate in Painless Gastroenteroscopy: Mechanism, Efficacy and Safety
摘要: 随着现代医学的发展，无痛胃肠镜检查成为了消化系统疾病的重要诊疗手段，人们对医疗过程的舒适性及安全性也有了新的要求。甲苯磺酸瑞马唑仑(Remimazolam Tosylate)是一种超短效的苯二氮类镇静药物，具有清除率高、作用时间短、恢复快、血流动力学稳定、呼吸抑制作用小等优点。富马酸奥赛利定(Oliceridine)作为一种G蛋白偏向性μ-阿片受体激动剂，有镇痛效果与传统阿片类药物类似，但不良反应发生率更低的优点。然而，这两种药物联合应用于无痛胃肠镜中的研究仍处于初步阶段。本文主要论述了瑞马唑仑与奥赛利定联合使用的作用机制、药理特点以及临床应用，系统分析了两者联合应用于无痛胃肠镜的相关机制、疗效及安全性，为其在临床上合理使用提供依据。
Abstract: With the advancement of modern medicine, painless gastrointestinal endoscopy has become an essential diagnostic and therapeutic tool for digestive system diseases, and patient expectations regarding the comfort and safety of medical procedures have increased accordingly. Remimazolam Tosylate is an ultra-short-acting benzodiazepine sedative characterized by its high clearance rate, short duration of action, rapid recovery, hemodynamic stability, and minimal respiratory depression. Oliceridine Fumarate, a G protein-biased μ-opioid receptor agonist (MOR), offers analgesic efficacy comparable to traditional opioids with a lower incidence of adverse effects. However, research on the combined application of these two drugs in painless gastrointestinal endoscopy remains in its preliminary stages. This review primarily discusses the mechanisms of action, pharmacological characteristics, and clinical applications of Remimazolam and Oliceridine. It systematically analyzes the mechanisms, efficacy, and safety associated with their combined use in painless gastrointestinal endoscopy, aiming to provide a basis for their rational clinical use.
文章引用：刘晓熠, 黎娟娟, 赵倩, 朱子君, 杨毅. 甲苯磺酸瑞马唑仑联合富马酸奥赛利定在无痛胃肠镜中的应用：机制、疗效与安全性[J]. 临床医学进展, 2025, 15(8): 1047-1056. https://doi.org/10.12677/acm.2025.1582332

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