五音角调治疗对肝郁气滞型不寐患者睡眠结构的影响

The Impact of Five-Tone Jiao Mode Music Therapy on Sleep Structure in Patients with Liver Qi Stagnation Insomnia

摘要: 目的：探讨五音角调音乐联合右佐匹克隆片治疗对肝郁气滞型不寐患者的临床疗效，重点分析其在改善中医症候积分、匹兹堡睡眠质量指数(PSQI)及多导睡眠图(PSG)等指标方面的应用价值。旨在验证五音角调音乐作为辅助干预手段在调节情志、优化睡眠结构中的作用，为中西医结合治疗失眠提供理论依据与实践支持。方法：选取2024年6月至2024年12月期间在乌鲁木齐市第四人民医院就诊的118例符合纳入标准的肝郁气滞型不寐患者，采用随机数字表法分为对照组(n = 59)和治疗组(n = 59)。对照组给予右佐匹克隆片口服治疗，剂量范围为1/3 mg~1 mg，疗程为28天；治疗组在对照组基础上联合使用五音角调音乐治疗，每日上午进行一次，每次30分钟，连续治疗4周。通过比较两组患者治疗前后中医症候积分量表、PSQI评分及PSG相关指标的变化，评估五音角调音乐的临床疗效。结果：(1) 中医症候积分方面：两组患者治疗后中医症候积分均显著降低(P < 0.05)，且治疗组改善优于对照组(P < 0.05)。(2) PSQI评分方面：两组患者治疗后各项指标(除“使用睡眠药物”外)均显著改善(P < 0.05)，其中治疗组在“睡眠质量”、“入睡潜伏期”、“白天功能紊乱”、“总分”等方面显著优于对照组(P < 0.05)。(3) PSG参数方面：两组患者治疗后总睡眠时间、睡眠效率显著提高(P < 0.05)，觉醒时间、觉醒时间占总睡眠时间百分比显著下降(P < 0.05)。治疗组在总睡眠时间、睡眠效率、觉醒时间、觉醒时间占总睡眠时间百分比等指标上均优于对照组(P < 0.05)。结论：五音角调音乐联合右佐匹克隆片可显著改善肝郁气滞型不寐患者的中医证候表现、主观睡眠质量及客观睡眠结构，尤其在提升睡眠效率、延长总睡眠时间、减少夜间觉醒等方面效果突出。作为一种非侵入性、无副作用的辅助疗法，五音角调音乐在调节情志、增强自我修复能力方面展现出独特优势，为失眠患者提供了易接受的综合干预方案。

Abstract: Objective: To investigate the clinical efficacy of Jiao-mode Five-Tone Music combined with eszopiclone in the treatment of insomnia patients with liver qi stagnation syndrome, with a focus on its impact on improving Traditional Chinese Medicine (TCM) syndrome scores, Pittsburgh Sleep Quality Index (PSQI) scores, and polysomnography (PSG) parameters. This study aims to verify the role of Jiao-mode Five-Tone Music as an adjunctive intervention in regulating emotions and optimizing sleep architecture, providing both theoretical basis and practical support for integrated Chinese and Western medical approaches in insomnia treatment. Methods: A total of 118 patients diagnosed with liver qi stagnation-type insomnia who visited the Fourth People’s Hospital of Urumqi between June 2024 and December 2024 were enrolled and randomly assigned to either the control group (n = 59) or the treatment group (n = 59) using a random number table method. The control group received oral administration of eszopiclone at a dose range of 1/3 mg to 1 mg for 28 days. The treatment group received additional Jiao-mode Five-Tone Music therapy based on the same medication regimen, with one session per day (30 minutes per session), conducted continuously for 4 weeks. The clinical effectiveness was evaluated by comparing changes in TCM syndrome scores, PSQI scores, and PSG parameters before and after treatment between the two groups. Results: (1) TCM Syndrome Scores: Both groups showed significant reductions in TCM syndrome scores after treatment (P < 0.05), and the improvement in the treatment group was significantly greater than that in the control group (P < 0.05). (2) PSQI Scores: All dimensions except “use of sleep medications” improved significantly after treatment in both groups (P < 0.05). The treatment group demonstrated superior improvements in “sleep quality”, “sleep latency”, “daytime dysfunction”, and “total score” compared to the control group (P < 0.05). (3) PSG Parameters: After treatment, both groups showed significant improvements in total sleep time (TST) and sleep efficiency (SE), along with significant decreases in wake time after sleep onset (WT) and percentage of wake time relative to total sleep time (WASO%) (P < 0.05). The treatment group outperformed the control group in terms of TST, SE, WT, and WASO% (P < 0.05). Conclusion: The combination of Jiao-mode Five-Tone Music and eszopiclone significantly improves TCM syndrome manifestations, subjective sleep quality, and objective sleep structure in patients with liver qi stagnation-type insomnia, particularly in enhancing sleep efficiency, prolonging total sleep duration, and reducing nighttime awakenings. As a non-invasive, side-effect-free complementary therapy, Jiao-mode Five-Tone Music demonstrates unique advantages in emotional regulation and enhancement of self-repair capabilities. This method provides an acceptable comprehensive intervention approach for patients with insomnia.