抑郁障碍患者注意偏向与反刍思维特点研究进展
Research Progress on Attention Bias and Rumination Characteristics in Patients with Depressive Disorders
DOI: 10.12677/acm.2025.1582345, PDF,   
作者: 高 旭:延安大学医学院,陕西 延安
关键词: 抑郁注意偏向反刍思维Depression Attention Bias Rumination
摘要: 了解注意偏向、反刍思维与抑郁之间的关系,是认知心理学和临床心理学研究的重要课题之一。抑郁患者可能出现快感缺失、重复反刍以及认知障碍这些显著特点。在以往的研究中,反刍思维的测量主要采用问卷法、实验室诱导法以及动态评估等方法进行。反刍思维的理论解释主要有反应风格理论、控制理论、脱离受损假说、压力反应模型、悲伤反刍模型、愤怒反刍模型、目标进展理论、元认知模型。目前的研究结果表明,注意偏向、反刍与抑郁紧密相连,三者形成一种复杂的、相互强化的恶性循环,共同维持和加剧抑郁症状,但对于三者的因果关系仍未确定。因此,本文对于抑郁患者的注意偏向与反刍思维的相关概念和理论、测量方法、神经机制以及现有研究情况进行了讨论,并对未来的研究方向进行了展望。
Abstract: Understanding the relationship between attentional bias, rumination, and depression is one of the important topics in cognitive psychology and clinical psychology research. Depressed patients may exhibit significant characteristics such as anhedonia, rumination, and cognitive impairment. In previous studies, rumination has been measured primarily using questionnaires, laboratory induc-tion methods, and dynamic assessment methods. The theoretical explanations for rumination in-clude reaction style theory, control theory, disengagement hypothesis, stress response model, sad-ness rumination model, anger rumination model, goal progress theory, and metacognitive model. Current research findings indicate that attentional bias, rumination, and depression are closely linked, forming a complex, mutually reinforcing vicious cycle that jointly maintains and exacerbates depressive symptoms. However, the causal relationship between the three remains unclear. There-fore, this paper discusses the relevant concepts and theories, measurement methods, neural mechanisms, and current research status of attentional bias and rumination in patients with de-pression, and provides an outlook on future research directions.
文章引用:高旭. 抑郁障碍患者注意偏向与反刍思维特点研究进展[J]. 临床医学进展, 2025, 15(8): 1141-1152. https://doi.org/10.12677/acm.2025.1582345

参考文献

[1] Cuijpers, P. (2018) The Challenges of Improving Treatments for Depression. JAMA, 320, 2529-2530. [Google Scholar] [CrossRef] [PubMed]
[2] World Health Organization (2024) Depression.
https://www.who.int/health-topics/depression
[3] Otte, C., Gold, S.M., Penninx, B.W., Pariante, C.M., Etkin, A., Fava, M., et al. (2016) Major Depressive Disorder. Nature Reviews Disease Primers, 2, Article No. 16065. [Google Scholar] [CrossRef] [PubMed]
[4] Patel, V., Saxena, S., Lund, C., Thornicroft, G., Baingana, F., Bolton, P., et al. (2018) The Lancet Commission on Global Mental Health and Sustainable Development. The Lancet, 392, 1553-1598. [Google Scholar] [CrossRef] [PubMed]
[5] Ferrari, A.J., Santomauro, D.F., Aali, A., Abate, Y.H., Abbafati, C., Abbastabar, H., et al. (2024) Global Incidence, Prevalence, Years Lived with Disability (YLDs), Disability-Adjusted Life-Years (DALYs), and Healthy Life Expectancy (HALE) for 371 Diseases and Injuries in 204 Countries and Territories and 811 Subnational Locations, 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021. The Lancet, 403, 2133-2161. [Google Scholar] [CrossRef] [PubMed]
[6] COVID-19 Mental Disorders Collaborators (2021) Global Prevalence and Burden of Depressive and Anxiety Disorders in 204 Countries and Territories in 2020 Due to the Covid-19 Pandemic. Lancet, 398, 1700-1712.
[7] Dadi, A.F., Miller, E.R., Bisetegn, T.A. and Mwanri, L. (2020) Global Burden of Antenatal Depression and Its Association with Adverse Birth Outcomes: An Umbrella Review. BMC Public Health, 20, Article No. 173. [Google Scholar] [CrossRef] [PubMed]
[8] Riso, L.P., Miyatake, R.K. and Thase, M.E. (2002) The Search for Determinants of Chronic Depression: A Review of Six Factors. Journal of Affective Disorders, 70, 103-115. [Google Scholar] [CrossRef] [PubMed]
[9] Beck, A.T. and Haigh, E.A.P. (2014) Advances in Cognitive Theory and Therapy: The Generic Cognitive Model. Annual Review of Clinical Psychology, 10, 1-24. [Google Scholar] [CrossRef] [PubMed]
[10] 夏海莎, 李雨谿, 刘小菠, 等. 抑郁患者情绪面孔注视特征: 基于眼动研究的Meta分析[J]. 中国组织工程研究, 2022, 26(29): 4735-4741.
[11] De Raedt, R. and Koster, E.H.W. (2010) Understanding Vulnerability for Depression from a Cognitive Neuroscience Perspective: A Reappraisal of Attentional Factors and a New Conceptual Framework. Cognitive, Affective, & Behavioral Neuroscience, 10, 50-70. [Google Scholar] [CrossRef] [PubMed]
[12] Shamai-Leshem, D., Linetzky, M. and Bar-Haim, Y. (2022) Attention Biases in Previously Depressed Individuals: A Meta-Analysis and Implications for Depression Recurrence. Cognitive Therapy and Research, 46, 1033-1048. [Google Scholar] [CrossRef
[13] Gibb, B.E., McGeary, J.E. and Beevers, C.G. (2015) Attentional Biases to Emotional Stimuli: Key Components of the RDOC Constructs of Sustained Threat and Loss. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171, 65-80. [Google Scholar] [CrossRef] [PubMed]
[14] Disner, S.G., Shumake, J.D. and Beevers, C.G. (2016) Self-referential Schemas and Attentional Bias Predict Severity and Naturalistic Course of Depression Symptoms. Cognition and Emotion, 31, 632-644. [Google Scholar] [CrossRef] [PubMed]
[15] Abela, J.R.Z. and Hankin, B.L. (2011) Rumination as a Vulnerability Factor to Depression during the Transition from Early to Middle Adolescence: A Multiwave Longitudinal Study. Journal of Abnormal Psychology, 120, 259-271. [Google Scholar] [CrossRef] [PubMed]
[16] Nolen-Hoeksema, S. (1991) Responses to Depression and Their Effects on the Duration of Depressive Episodes. Journal of Abnormal Psychology, 100, 569-582. [Google Scholar] [CrossRef
[17] Owens, M. and Gibb, B.E. (2016) Brooding Rumination and Attentional Biases in Currently Non-Depressed Individuals: An Eye-Tracking Study. Cognition and Emotion, 31, 1062-1069. [Google Scholar] [CrossRef] [PubMed]
[18] Hilt, L.M. and Pollak, S.D. (2013) Characterizing the Ruminative Process in Young Adolescents. Journal of Clinical Child & Adolescent Psychology, 42, 519-530. [Google Scholar] [CrossRef] [PubMed]
[19] Baert, S., De Raedt, R. and Koster, E.H.W. (2010) Depression-Related Attentional Bias: The Influence of Symptom Severity and Symptom Specificity. Cognition & Emotion, 24, 1044-1052. [Google Scholar] [CrossRef
[20] Holas, P., Krejtz, I., Rusanowska, M., Rohnka, N. and Nezlek, J.B. (2018) Attention to Negative Words Predicts Daily Rumination among People with Clinical Depression: Evidence from an Eye Tracking and Daily Diary Study. Cognition and Emotion, 33, 1277-1283. [Google Scholar] [CrossRef] [PubMed]
[21] 徐芷晗. 青少年抑郁障碍伴非自杀性自伤: 注意偏向和反刍思维的链式中介作用[D]: [硕士学位论文]. 泸州: 西南医科大学, 2024.
[22] Koster, E.H.W., De Lissnyder, E., Derakshan, N. and De Raedt, R. (2011) Understanding Depressive Rumination from a Cognitive Science Perspective: The Impaired Disengagement Hypothesis. Clinical Psychology Review, 31, 138-145. [Google Scholar] [CrossRef] [PubMed]
[23] 戴琴, 冯正直. 抑郁患者的注意偏向[J]. 心理科学进展, 2008(2): 260-265.
[24] Cisler, J.M. and Koster, E.H.W. (2010) Mechanisms of Attentional Biases towards Threat in Anxiety Disorders: An Integrative Review. Clinical Psychology Review, 30, 203-216. [Google Scholar] [CrossRef] [PubMed]
[25] 高旭. 抑郁患者注意偏向研究进展[J]. 临床医学进展, 2024, 14(9): 320-327.
[26] Xia, H., Li, Y., Zhang, Q., Zhong, D., Liu, X., Gou, X., et al. (2023) Attention Bias Modification for Depression: A Systematic Review and Meta-Analysis. Frontiers in Psychiatry, 14, Article 1098610. [Google Scholar] [CrossRef] [PubMed]
[27] Beck, A.T. (1995) Cognitive Therapy: Basics and Beyond. Guilford Press.
[28] 张立伟. 抑郁倾向个体负性注意偏向及神经机制研究[D]: [博士学位论文]. 大连: 辽宁师范大学, 2019.
[29] Hasher, L. and Zacks, R.T. (1988) Working Memory, Comprehension, and Aging: A Review and a New View. Psychology of Learning and Motivation, 22, 193-225. [Google Scholar] [CrossRef
[30] Koster, E.H.W., Raedt, R.D., Verschuere, B., Tibboel, H. and De Jong, P.J. (2009) Negative Information Enhances the Attentional Blink in Dysphoria. Depression and Anxiety, 26, E16-E22. [Google Scholar] [CrossRef] [PubMed]
[31] Treynor, W., Gonzalez, R. and Nolen-Hoeksema, S. (2003) Rumination Reconsidered: A Psychometric Analysis. Cognitive Therapy and Research, 27, 247-259. [Google Scholar] [CrossRef
[32] Conway, M., Csank, P.A.R., Holm, S.L. and Blake, C.K. (2000) On Assessing Individual Differences in Rumination on Sadness. Journal of Personality Assessment, 75, 404-425. [Google Scholar] [CrossRef] [PubMed]
[33] Conway, M., Alfonsi, G., Pushkar, D. and Giannopoulos, C. (2008) Rumination on Sadness and Dimensions of Communality and Agency: Comparing White and Visible Minority Individuals in a Canadian Context. Sex Roles, 58, 738-749. [Google Scholar] [CrossRef
[34] Smith, J.M. and Alloy, L.B. (2009) A Roadmap to Rumination: A Review of the Definition, Assessment, and Conceptualization of This Multifaceted Construct. Clinical Psychology Review, 29, 116-128. [Google Scholar] [CrossRef] [PubMed]
[35] Sukhodolsky, D.G., Golub, A. and Cromwell, E.N. (2001) Development and Validation of the Anger Rumination Scale. Personality and Individual Differences, 31, 689-700. [Google Scholar] [CrossRef
[36] Papageorgiou, C. and Wells, A. (2001) Metacognitive Beliefs about Rumination in Recurrent Major Depression. Cognitive and Behavioral Practice, 8, 160-164. [Google Scholar] [CrossRef
[37] Lyubomirsky, S., Caldwell, N.D. and Nolen-Hoeksema, S. (1998) Effects of Ruminative and Distracting Responses to Depressed Mood on Retrieval of Autobiographical Memories. Journal of Personality and Social Psychology, 75, 166-177. [Google Scholar] [CrossRef
[38] 封丹珺, 石林. 应对方式的生态瞬时评估法及其他测量方法简介[J]. 心理科学进展, 2004(3): 429-434.
[39] Watkins, E.R. (2008) Constructive and Unconstructive Repetitive Thought. Psychological Bulletin, 134, 163-206. [Google Scholar] [CrossRef] [PubMed]
[40] Nolen-Hoeksema, S., Wisco, B.E. and Lyubomirsky, S. (2008) Rethinking Rumination. Perspectives on Psychological Science, 3, 400-424. [Google Scholar] [CrossRef] [PubMed]
[41] Nolen-Hoeksema, S. (1987) Sex Differences in Unipolar Depression: Evidence and Theory. Psychological Bulletin, 101, 259-282. [Google Scholar] [CrossRef
[42] Robinson, M.S. and Alloy, L.B. (2003) Negative Cognitive Styles and Stress-Reactive Rumination Interact to Predict Depression: A Prospective Study. Cognitive Therapy and Research, 27, 275-291. [Google Scholar] [CrossRef
[43] Lyubomirsky, S. and Tkach, C. (2004) The Consequences of Dysphoric Rumination. In: Papageorgiou, C. and Wells, A., Eds., Depressive Rumination: Nature, Theory, and Treatment, Wiley, 21-41. [Google Scholar] [CrossRef
[44] Averill, J.R. (1983) Studies on Anger and Aggression: Implications for Theories of Emotion. American Psychologist, 38, 1145-1160. [Google Scholar] [CrossRef
[45] Spielberger, C.D. (1988) Manual for the State-Trait Anger Expression Inventory (STAXI). Psychological Assessment Resources. [Google Scholar] [CrossRef
[46] Ingram, R.E. (1990) Self-Focused Attention in Clinical Disorders: Review and a Conceptual Model. Psychological Bulletin, 107, 156-176. [Google Scholar] [CrossRef] [PubMed]
[47] Martin, L.L., Tesser, A. and Mcintosh, W.D. (1993) Wanting but Not Having: The Effects of Unattained Goals on Thoughts and Feelings. In Wegner, D.M. and Pennebaker, J.W., Eds., Handbook of Mental Control, Prentice-Hall, Inc., 552-572.
[48] Wells, A. (2009) Metacognitive Therapy for Anxiety and Depression. Guilford Press
[49] Cano-López, J.B., Salguero, J.M., García-Sancho, E. and Ramos-Cejudo, J. (2020) Testing the Metacognitive Model of Rumination and Depression in Non-Clinical Population: New Data about PBRS and NBRS Scales. Journal of Psychopathology and Behavioral Assessment, 43, 240-250. [Google Scholar] [CrossRef
[50] Joormann, J. and Gotlib, I.H. (2008) Updating the Contents of Working Memory in Depression: Interference from Irrelevant Negative Material. Journal of Abnormal Psychology, 117, 182-192. [Google Scholar] [CrossRef] [PubMed]
[51] 龙思娜, 周义茜, 阮江海. 反刍思维脑网络及范式研究进展[J]. 中国医疗设备, 2024, 39(12): 146-152.
[52] Andrews-Hanna, J.R. (2011) The Brain’s Default Network and Its Adaptive Role in Internal Mentation. The Neuroscientist, 18, 251-270. [Google Scholar] [CrossRef] [PubMed]
[53] Beevers, C.G., Wells, T.T., Ellis, A.J. and McGeary, J.E. (2009) Association of the Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism with Biased Attention for Emotional Stimuli. Journal of Abnormal Psychology, 118, 670-681. [Google Scholar] [CrossRef] [PubMed]
[54] Chen, X., Chen, N., Shen, Y., Li, H., Li, L., Lu, B., et al. (2020) The Subsystem Mechanism of Default Mode Network Underlying Rumination: A Reproducible Neuroimaging Study. NeuroImage, 221, Article ID: 117185. [Google Scholar] [CrossRef] [PubMed]
[55] Li, X., Qin, F., Liu, J., Luo, Q., Zhang, Y., Hu, J., et al. (2022) An Insula-Based Network Mediates the Relation between Rumination and Interoceptive Sensibility in the Healthy Population. Journal of Affective Disorders, 299, 6-11. [Google Scholar] [CrossRef] [PubMed]
[56] Feurer, C., Jimmy, J., Chang, F., Langenecker, S.A., Phan, K.L., Ajilore, O., et al. (2021) Resting State Functional Connectivity Correlates of Rumination and Worry in Internalizing Psychopathologies. Depression and Anxiety, 38, 488-497. [Google Scholar] [CrossRef] [PubMed]
[57] Taylor, J.G. and Fragopanagos, N.F. (2005) The Interaction of Attention and Emotion. Neural Networks, 18, 353-369. [Google Scholar] [CrossRef] [PubMed]
[58] Kertz, S.J., Petersen, D.R. and Stevens, K.T. (2019) Cognitive and Attentional Vulnerability to Depression in Youth: A Review. Clinical Psychology Review, 71, 63-77. [Google Scholar] [CrossRef] [PubMed]
[59] Kross, E. (2009) When the Self Becomes Other: Toward an Integrative Understanding of the Processes Distinguishing Adaptive Self-Reflection from Rumination. Annals of the New York Academy of Sciences, 1167, 35-40. [Google Scholar] [CrossRef] [PubMed]
[60] Nolen-Hoeksema, S. (2000) The Role of Rumination in Depressive Disorders and Mixed Anxiety/Depressive Symptoms. Journal of Abnormal Psychology, 109, 504-511. [Google Scholar] [CrossRef] [PubMed]
[61] Blaney, P.H. (1986) Affect and Memory: A Review. Psychological Bulletin, 99, 229-246. [Google Scholar] [CrossRef
[62] Teasdale, J.D. (1988) Cognitive Vulnerability to Persistent Depression. Cognition & Emotion, 2, 247-274. [Google Scholar] [CrossRef
[63] Johnson, D.P., Rhee, S.H., Friedman, N.P., Corley, R.P., Munn-Chernoff, M.A., Hewitt, J.K., et al. (2016) A Twin Study Examining Rumination as a Transdiagnostic Correlate of Psychopathology. Clinical Psychological Science, 4, 971-987. [Google Scholar] [CrossRef] [PubMed]
[64] Drost, J., van der Does, W., van Hemert, A.M., Penninx, B.W.J.H. and Spinhoven, P. (2014) Repetitive Negative Thinking as a Transdiagnostic Factor in Depression and Anxiety: A Conceptual Replication. Behaviour Research and Therapy, 63, 177-183. [Google Scholar] [CrossRef] [PubMed]
[65] 谭清宇, 刘平, 吕桃, 等. 青少年抑郁障碍患者失眠与自杀意念的关系: 反刍思维的中介作用[J]. 四川精神卫生, 2023, 36(2): 118-122.
[66] Snyder, H.R., Miyake, A. and Hankin, B.L. (2015) Advancing Understanding of Executive Function Impairments and Psychopathology: Bridging the Gap between Clinical and Cognitive Approaches. Frontiers in Psychology, 6, Article 328. [Google Scholar] [CrossRef] [PubMed]
[67] Whitmer, A.J. and Gotlib, I.H. (2013) An Attentional Scope Model of Rumination. Psychological Bulletin, 139, 1036-1061. [Google Scholar] [CrossRef] [PubMed]
[68] Allard, E.S. and Yaroslavsky, I. (2019) Attentional Disengagement Deficits Predict Brooding, but Not Reflection, over a One-Year Period. Frontiers in Psychology, 10, Article 2282. [Google Scholar] [CrossRef] [PubMed]
[69] Kertz, S.J., Stevens, K.T. and Klein, K.P. (2016) The Association between Attention Control, Anxiety, and Depression: The Indirect Effects of Repetitive Negative Thinking and Mood Recovery. Anxiety, Stress, & Coping, 30, 456-468. [Google Scholar] [CrossRef] [PubMed]
[70] Dandeneau, S.D., Baldwin, M.W., Baccus, J.R., Sakellaropoulo, M. and Pruessner, J.C. (2007) Cutting Stress off at the Pass: Reducing Vigilance and Responsiveness to Social Threat by Manipulating Attention. Journal of Personality and Social Psychology, 93, 651-666. [Google Scholar] [CrossRef] [PubMed]
[71] Arenliu, A., Konjufca, J., Meiran, N., Weine, S. and Langenecker, S.A. (2023) Attentional Bias among High and Low Ruminators: Eye Tracking Study in a Non-Clinical Population. Sage Open, 13, 1-8. [Google Scholar] [CrossRef
[72] Donaldson, C., Lam, D. and Mathews, A. (2007) Rumination and Attention in Major Depression. Behaviour Research and Therapy, 45, 2664-2678. [Google Scholar] [CrossRef] [PubMed]
[73] Southworth, F., Grafton, B., MacLeod, C. and Watkins, E. (2016) Heightened Ruminative Disposition Is Associated with Impaired Attentional Disengagement from Negative Relative to Positive Information: Support for the “Impaired Disengagement” Hypothesis. Cognition and Emotion, 31, 422-434. [Google Scholar] [CrossRef] [PubMed]
[74] Joormann, J., Dkane, M. and Gotlib, I.H. (2006) Adaptive and Maladaptive Components of Rumination? Diagnostic Specificity and Relation to Depressive Biases. Behavior Therapy, 37, 269-280. [Google Scholar] [CrossRef] [PubMed]
[75] Duque, A., Sanchez, A. and Vazquez, C. (2014) Gaze-Fixation and Pupil Dilation in the Processing of Emotional Faces: The Role of Rumination. Cognition and Emotion, 28, 1347-1366. [Google Scholar] [CrossRef] [PubMed]
[76] 曾凯搏. 中性和正性注意偏向训练改善抑郁症状和冗思的作用比较[D]: [硕士学位论文]. 长沙: 湖南师范大学, 2018.
[77] Miller, C.H., Hamilton, J.P., Sacchet, M.D. and Gotlib, I.H. (2015) Meta-Analysis of Functional Neuroimaging of Major Depressive Disorder in Youth. JAMA Psychiatry, 72, 1045-1053. [Google Scholar] [CrossRef] [PubMed]