乳腺癌微钙化相关生物标志物和临床预后的研究进展
Research Progress on Biomarkers Associated with Breast Cancer Microcalcifications and Clinical Prognosis
DOI: 10.12677/jcpm.2025.44446, PDF,    科研立项经费支持
作者: 李功政*：济宁医学院临床医学院(附属医院)，山东 济宁；吕月涛#：济宁市第一人民医院乳甲外科，山东 济宁
关键词: 乳腺癌；微钙化；生物标志物；综述；预后；Breast Cancer； Microcalcifications； Biomarkers； Review； Prognosis
摘要: 微钙化是乳腺癌早期诊断的重要影像学标志，但其相关的生物标志物及其与预后的关联仍需系统阐释。本文旨在整合微钙化的相关生物标志物及影像学特征，探讨其在乳腺癌分子分型、恶性进展及预后评估中的临床意义。通过总结微钙化的成分特征(羟基磷灰石与草酸钙)、相关生物标志物(如OPN、BMP-2、HER-2、HIF-1α及PTX3等)，分析其形态与分布的影像学特征，并评估其与乳腺癌分子分型及预后的关联。
Abstract: Microcalcifications serve as crucial imaging markers for the early diagnosis of breast cancer; however, the associated biomarkers and their links to prognosis require comprehensive elucidation. This review aims to integrate the relevant biomarkers and imaging characteristics of microcalcifications, exploring their clinical significance in breast cancer molecular subtyping, malignant progression, and prognostic assessment. We summarize the compositional features of microcalcifications (hydroxyapatite vs. calcium oxalate), review associated biomarkers (such as OPN, BMP-2, HER-2, HIF-1α, and PTX3), analyze their morphological and distributional characteristics on imaging, and evaluate their associations with breast cancer molecular subtypes and prognosis.
文章引用：李功政, 吕月涛. 乳腺癌微钙化相关生物标志物和临床预后的研究进展[J]. 临床个性化医学, 2025, 4(4): 285-293. https://doi.org/10.12677/jcpm.2025.44446

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