心力衰竭患者衰弱研究进展
Research Progress on Frailty in Patients with Heart Failure
DOI: 10.12677/md.2025.154056, PDF,    科研立项经费支持
作者: 张 艳*, 何 芬*, 张 琴：贵州中医药大学第二附属医院门诊部，贵州 贵阳；孙安会, 舒 华, 蒋清安#：贵州中医药大学第二附属医院心血管病内科，贵州 贵阳
关键词: 衰弱；心力衰竭；肌少症；炎症；衰弱综合征；Frailty； Heart Failure； Sarcopenia； Inflammation； Frailty Syndrome
摘要: 衰弱在心力衰竭患者中呈高发病率，并伴随高不良结局风险。炎症、肌少症和神经激素失调等促成因素会耗损生理储备并加速健康状况恶化，因而需采用多学科方法管理来满足身体、营养和药理学需求。饮食支持和结构化运动可以改善身体机能，而谨慎的药物管理可以降低与衰弱相关的风险。远程医疗和可穿戴技术有助于持续监控和及时干预。未来研究方向应旨在研发标准化衰弱评估工具及新疗法，强化风险分层和个性化护理。解决社会经济因素也可以提高护理公平性。本综述总结了衰弱对心力衰竭的机制、临床特征、治疗挑战和预后影响。
Abstract: Frailty has a high incidence rate in patients with heart failure and is associated with a high risk of adverse outcomes. Triggers such as inflammation, sarcopenia, and neurohormonal disorders can deplete physiological reserves and accelerate the deterioration of health, thus requiring a multidisciplinary approach to management to meet physical, nutritional, and pharmacological needs. Dietary support and structured exercise can improve physical function, while cautious medication management can reduce the risks associated with frailty. Remote healthcare and wearable technology help with continuous monitoring and timely intervention. The future research direction should aim to develop standardized frailty assessment tools and new therapies, strengthen risk stratification and personalized care. Addressing socio-economic factors can also improve nursing equity. This review summarizes the mechanism, clinical characteristics, treatment challenges, and prognostic impact of frailty on heart failure.
文章引用：张艳, 何芬, 张琴, 孙安会, 舒华, 蒋清安. 心力衰竭患者衰弱研究进展[J]. 医学诊断, 2025, 15(4): 417-427. https://doi.org/10.12677/md.2025.154056

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