荔枝核提取物治疗非酒精性脂肪性肝炎作用的研究进展
Research Progress on the Therapeutic Effect of Lychee Seed Extract on Non-Alcoholic Steatohepatitis
摘要: 近年来，非酒精性脂肪性肝炎(NASH)的发病率不断上升，其发病机制复杂，包括糖、脂、胆固醇代谢改变、纤维化进展、炎症、免疫等。目前为止FDA尚未批准任何用于NASH治疗的药物。荔枝核作为荔枝的一部分，常常和果皮一起被丢弃，根据药理学研究显示，其具有相当大的利用价值。荔枝核提取物(LSE)中含有多种化合物，如多酚类、黄酮类、多糖和脂肪酸等，具有降血糖、抗氧化、调节肠道微生物群和脂质代谢等多种活性。因此，应更深一步了解LSE的药用价值，研究其对NASH的影响及其机制，为治疗NASH疾病提供新思路。
Abstract: In recent years, the incidence rate of Nonalcoholic Steatohepatitis (NASH) has been rising, and its pathogenesis is complex, including changes in sugar, lipid, and cholesterol metabolism, fibrosis progression, inflammation, immunity, etc. So far, the FDA has not approved any drugs for the treatment of NASH. As a part of lychee, lychee seeds are often discarded together with the litchi peel. Pharmacological studies have shown that they have considerable utilization value. Lychee Seed Extract (LSE) contains various compounds such as polyphenols, flavonoids, polysaccharides, and fatty acids, which have various activities such as lowering blood sugar, antioxidation, regulating intestinal microbiota and lipid metabolism. Therefore, it is necessary to understand the medicinal value of LSE further, study its effects and mechanisms on NASH, and provide new ideas for the treatment of NASH diseases.
文章引用：司砚汀, 蔡怡盈, 郭咏鑫, 周红权, 范正洋, 满淑丽, 彭伟盼. 荔枝核提取物治疗非酒精性脂肪性肝炎作用的研究进展[J]. 亚洲急诊医学病例研究, 2025, 13(3): 291-299. https://doi.org/10.12677/acrem.2025.133041

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