肥胖与心血管疾病的临床研究进展
Clinical Research Advances in Obesity and Cardiovascular Disorders
DOI: 10.12677/acm.2025.1582352, PDF,   
作者: 杨丽丽*, 孙 欣#:内蒙古民族大学第二临床医学院(内蒙古林业总医院),内蒙古 牙克石
关键词: 肥胖心血管疾病临床研究进展Obesity CVD Progress in Clinical Studies
摘要: 肥胖是心血管疾病(CVD)发展的既定危险因素。肥胖会增加患CVD的风险,并导致其他心血管危险因素(如糖尿病、血脂异常和高血压)的发展。肥胖与代谢、激素和炎症有关,可导致动脉粥样硬化并增加冠状动脉疾病的风险,心肌重塑增加心力衰竭的风险。本文将研究肥胖对CVD风险的影响,并探讨肥胖和CVD之间的关系。
Abstract: Obesity is a well-established risk factor for the development of cardiovascular disease (CVD). It increases the risk of CVD and contributes to the development of other cardiovascular risk factors, such as diabetes, dyslipidemia, and hypertension. Obesity is associated with metabolic, hormonal, and inflammation changes that can lead to atherosclerosis and elevate the risk of coronary artery disease, while cardiac remodeling increases the risk of heart failure. This article examines the impact of obesity on CVD risk and explores the relationship between obesity and CVD.
文章引用:杨丽丽, 孙欣. 肥胖与心血管疾病的临床研究进展[J]. 临床医学进展, 2025, 15(8): 1196-1201. https://doi.org/10.12677/acm.2025.1582352

参考文献

[1] Safaei, M., Sundararajan, E.A., Driss, M., Boulila, W. and Shapi’i, A. (2021) A Systematic Literature Review on Obesity: Understanding the Causes & Consequences of Obesity and Reviewing Various Machine Learning Approaches Used to Predict Obesity. Computers in Biology and Medicine, 136, Article ID: 104754. [Google Scholar] [CrossRef] [PubMed]
[2] Gebreab, S.Z., Vandeleur, C.L., Rudaz, D., Strippoli, M.F., Gholam-Rezaee, M., Castelao, E., et al. (2018) Psychosocial Stress over the Lifespan, Psychological Factors, and Cardiometabolic Risk in the Community. Psychosomatic Medicine, 80, 628-639. [Google Scholar] [CrossRef] [PubMed]
[3] Sommer, I., Griebler, U., Mahlknecht, P., Thaler, K., Bouskill, K., Gartlehner, G., et al. (2015) Socioeconomic Inequalities in Non-Communicable Diseases and Their Risk Factors: An Overview of Systematic Reviews. BMC Public Health, 15, Article No. 914. [Google Scholar] [CrossRef] [PubMed]
[4] Sallis, J.F. and Glanz, K. (2009) Physical Activity and Food Environments: Solutions to the Obesity Epidemic. The Milbank Quarterly, 87, 123-154. [Google Scholar] [CrossRef] [PubMed]
[5] (2000) Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation. World Health Organ. Tech. Rep. Ser., 894: i-xii, 1-253.
[6] Powell-Wiley, T.M., Poirier, P., Burke, L.E., Després, J., Gordon-Larsen, P., Lavie, C.J., et al. (2021) Obesity and Cardiovascular Disease: A Scientific Statement from the American Heart Association. Circulation, 143, e984-e1010. [Google Scholar] [CrossRef] [PubMed]
[7] Mandviwala, T., Khalid, U. and Deswal, A. (2016) Obesity and Cardiovascular Disease: A Risk Factor or a Risk Marker? Current Atherosclerosis Reports, 18, Article No. 21. [Google Scholar] [CrossRef] [PubMed]
[8] Engin, A. (2017) Endothelial Dysfunction in Obesity. In: Advances in Experimental Medicine and Biology, Springer International Publishing, 345-379. [Google Scholar] [CrossRef] [PubMed]
[9] Kershaw, E.E. and Flier, J.S. (2004) Adipose Tissue as an Endocrine Organ. The Journal of Clinical Endocrinology & Metabolism, 89, 2548-2556. [Google Scholar] [CrossRef] [PubMed]
[10] Nakamura, K., Fuster, J.J. and Walsh, K. (2014) Adipokines: A Link between Obesity and Cardiovascular Disease. Journal of Cardiology, 63, 250-259. [Google Scholar] [CrossRef] [PubMed]
[11] Ebong, I.A., Goff, D.C., Rodriguez, C.J., Chen, H. and Bertoni, A.G. (2014) Mechanisms of Heart Failure in Obesity. Obesity Research & Clinical Practice, 8, e540-e548. [Google Scholar] [CrossRef] [PubMed]
[12] Horwich, T.B. and Fonarow, G.C. (2010) Glucose, Obesity, Metabolic Syndrome, and Diabetes Relevance to Incidence of Heart Failure. Journal of the American College of Cardiology, 55, 283-293. [Google Scholar] [CrossRef] [PubMed]
[13] Thomas, S.Y., Harmancey, R. and Taegtmeyer, H. (2010) Fat around the Heart. JACC: Cardiovascular Imaging, 3, 786-787. [Google Scholar] [CrossRef] [PubMed]
[14] Haidar, A. and Taegtmeyer, H. (2022) Strategies for Imaging Metabolic Remodeling of the Heart in Obesity and Heart Failure. Current Cardiology Reports, 24, 327-335. [Google Scholar] [CrossRef] [PubMed]
[15] Sharma, S., Adrogue, J.V., Golfman, L., Uray, I., Lemm, J., Youker, K., et al. (2004) Intramyocardial Lipid Accumulation in the Failing Human Heart Resembles the Lipotoxic Rat Heart. The FASEB Journal, 18, 1692-1700. [Google Scholar] [CrossRef] [PubMed]
[16] Asghar, O., Alam, U., A. Hayat, S., Aghamohammadzadeh, R., M. Heagerty, A. and A. Malik, R. (2012) Obesity, Diabetes and Atrial Fibrillation; Epidemiology, Mechanisms and Interventions. Current Cardiology Reviews, 8, 253-264. [Google Scholar] [CrossRef] [PubMed]
[17] Lee, S., Chen, Y., Chen, Y., Chang, S., Tai, C., Wongcharoen, W., et al. (2007) Tumor Necrosis Factor-Α Alters Calcium Handling and Increases Arrhythmogenesis of Pulmonary Vein Cardiomyocytes. Life Sciences, 80, 1806-1815. [Google Scholar] [CrossRef] [PubMed]
[18] Karason, K., Mølgaard, H., Wikstrand, J. and Sjöström, L. (1999) Heart Rate Variability in Obesity and the Effect of Weight Loss. The American Journal of Cardiology, 83, 1242-1247. [Google Scholar] [CrossRef] [PubMed]
[19] Jouven, X., Desnos, M., Guerot, C. and Ducimetière, P. (1999) Predicting Sudden Death in the Population: The Paris Prospective Study I. Circulation, 99, 1978-1983. [Google Scholar] [CrossRef] [PubMed]
[20] Csige, I., Ujvárosy, D., Szabó, Z., Lőrincz, I., Paragh, G., Harangi, M., et al. (2018) The Impact of Obesity on the Cardiovascular System. Journal of Diabetes Research, 2018, Article ID: 3407306. [Google Scholar] [CrossRef] [PubMed]
[21] Haslam, D.W. and James, W.P.T. (2005) Obesity. The Lancet, 366, 1197-1209. [Google Scholar] [CrossRef] [PubMed]
[22] Chen, Q., Zhang, Z., Luo, N. and Qi, Y. (2023) Elevated Visceral Adiposity Index Is Associated with Increased Stroke Prevalence and Earlier Age at First Stroke Onset: Based on a National Cross-Sectional Study. Frontiers in Endocrinology, 13, Article ID: 1086936. [Google Scholar] [CrossRef] [PubMed]
[23] NCD Risk Factor Collaboration (NCD-RisC) (2021) Worldwide Trends in Hypertension Prevalence and Progress in Treatment and Control from 1990 to 2019: A Pooled Analysis of 1201 Population-Representative Studies with 104 Million Participants. The Lancet, 398, 957-980.
[24] Hall, J.E., do Carmo, J.M., da Silva, A.A., Wang, Z. and Hall, M.E. (2015) Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms. Circulation Research, 116, 991-1006. [Google Scholar] [CrossRef] [PubMed]
[25] Lambert, E.A., Straznicky, N.E., Dixon, J.B. and Lambert, G.W. (2015) Should the Sympathetic Nervous System Be a Target to Improve Cardiometabolic Risk in Obesity? American Journal of Physiology-Heart and Circulatory Physiology, 309, H244-H258. [Google Scholar] [CrossRef] [PubMed]
[26] Cardillo, C., Campia, U., Iantorno, M. and Panza, J.A. (2004) Enhanced Vascular Activity of Endogenous Endothelin-1 in Obese Hypertensive Patients. Hypertension, 43, 36-40. [Google Scholar] [CrossRef] [PubMed]
[27] Chrysant, S.G. (2019) Pathophysiology and Treatment of Obesity‐Related Hypertension. The Journal of Clinical Hypertension, 21, 555-559. [Google Scholar] [CrossRef] [PubMed]
[28] DeMarco, V.G., Aroor, A.R. and Sowers, J.R. (2014) The Pathophysiology of Hypertension in Patients with Obesity. Nature Reviews Endocrinology, 10, 364-376. [Google Scholar] [CrossRef] [PubMed]
[29] Lewis, E.J., Hunsicker, L.G., Clarke, W.R., Berl, T., Pohl, M.A., Lewis, J.B., et al. (2001) Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes. New England Journal of Medicine, 345, 851-860. [Google Scholar] [CrossRef] [PubMed]
[30] Schlueter, N., de Sterke, A., Willmes, D.M., Spranger, J., Jordan, J. and Birkenfeld, A.L. (2014) Metabolic Actions of Natriuretic Peptides and Therapeutic Potential in the Metabolic Syndrome. Pharmacology & Therapeutics, 144, 12-27. [Google Scholar] [CrossRef] [PubMed]
[31] Moro, C. (2013) Natriuretic Peptides and Fat Metabolism. Current Opinion in Clinical Nutrition and Metabolic Care, 16, 645-649. [Google Scholar] [CrossRef] [PubMed]
[32] Lavie, C.J., Arena, R., Alpert, M.A., Milani, R.V. and Ventura, H.O. (2017) Management of Cardiovascular Diseases in Patients with Obesity. Nature Reviews Cardiology, 15, 45-56. [Google Scholar] [CrossRef] [PubMed]
[33] Elagizi, A., Kachur, S., Lavie, C.J., Carbone, S., Pandey, A., Ortega, F.B., et al. (2018) An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases. Progress in Cardiovascular Diseases, 61, 142-150. [Google Scholar] [CrossRef] [PubMed]
[34] Koliaki, C., Liatis, S. and Kokkinos, A. (2019) Obesity and Cardiovascular Disease: Revisiting an Old Relationship. Metabolism, 92, 98-107. [Google Scholar] [CrossRef] [PubMed]
[35] Horwich, T.B., Fonarow, G.C. and Clark, A.L. (2018) Obesity and the Obesity Paradox in Heart Failure. Progress in Cardiovascular Diseases, 61, 151-156. [Google Scholar] [CrossRef] [PubMed]
[36] Haidar, A. and Horwich, T. (2023) Obesity, Cardiorespiratory Fitness, and Cardiovascular Disease. Current Cardiology Reports, 25, 1565-1571. [Google Scholar] [CrossRef] [PubMed]
[37] Tutor, A., Lavie, C.J., Kachur, S., Dinshaw, H. and Milani, R.V. (2022) Impact of Cardiorespiratory Fitness on Outcomes in Cardiac Rehabilitation. Progress in Cardiovascular Diseases, 70, 2-7. [Google Scholar] [CrossRef] [PubMed]
[38] DeFina, L.F., Haskell, W.L., Willis, B.L., Barlow, C.E., Finley, C.E., Levine, B.D., et al. (2015) Physical Activity versus Cardiorespiratory Fitness: Two (Partly) Distinct Components of Cardiovascular Health? Progress in Cardiovascular Diseases, 57, 324-329. [Google Scholar] [CrossRef] [PubMed]
[39] Abulmeaty, M.M.A., Ghneim, H.K., Alkhathaami, A., Alnumair, K., Al Zaben, M., Razak, S., et al. (2023) Inflammatory Cytokines, Redox Status, and Cardiovascular Diseases Risk after Weight Loss via Bariatric Surgery and Lifestyle Intervention. Medicina, 59, Article No. 751. [Google Scholar] [CrossRef] [PubMed]
[40] Ryan, D.H., Lingvay, I., Colhoun, H.M., Deanfield, J., Emerson, S.S., Kahn, S.E., et al. (2020) Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) Rationale and Design. American Heart Journal, 229, 61-69. [Google Scholar] [CrossRef] [PubMed]