“正虚癌毒”理论视角下探讨结直肠癌的病机与中西医认识
Exploration on the Pathogenesis of Colorectal Cancer and the Understanding of Traditional Chinese and Western Medicine Based on the Theory of “Asthenia of Healthy Qi and Cancer Toxin”
DOI: 10.12677/acm.2025.1582370, PDF,   
作者: 蒋思雨:黑龙江中医药大学研究生院,黑龙江 哈尔滨;刘松江:黑龙江中医药大学附属第一医院肿瘤科,黑龙江 哈尔滨
关键词: 结直肠癌正虚癌毒病机Colorectal Cancer Asthenia of Healthy Qi Cancer Toxin Pathogenesis
摘要: 结直肠癌是常见且危害严重的消化道恶性肿瘤之一,中西医结合治疗可提高疗效。了解结直肠癌的病因及发病机制是早期预防及治疗的基础。
Abstract: Colorectal cancer is one of the common and seriously harmful malignant tumors of the digestive tract, and integrated traditional Chinese and Western medicine treatment can improve the curative effect. Understanding the etiology and pathogenesis of colorectal cancer is the basis for early prevention and treatment.
文章引用:蒋思雨, 刘松江. “正虚癌毒”理论视角下探讨结直肠癌的病机与中西医认识[J]. 临床医学进展, 2025, 15(8): 1328-1333. https://doi.org/10.12677/acm.2025.1582370

参考文献

[1] Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[2] 邵杰. 健脾化瘀方通过调控miR-130a-3p靶向WNT10B影响WNT信号通路参与结直肠癌发生发展的机制研究[D]: [博士学位论文]. 南京: 南京中医药大学, 2024.
[3] 唐琪琳, 杨帆, 王学岭. 大肠癌的中医病因病机及治疗研究概况[J]. 长春中医药大学学报, 2016, 32(1): 216-219.
[4] 徐春波, 沈敏鹤, 陶方方, 等. 基于系统聚类分析总结沈敏鹤主任医师辨治结直肠癌用药规律[J]. 新中医, 2020, 52(10): 183-186.
[5] 骆平平, 周燕群, 蒋钟霆, 等. 郭勇从脾胃辨治大肠癌经验浅析[J]. 浙江中西医结合杂志, 2018, 28(12): 987-989.
[6] 程海波, 吴勉华. 周仲瑛教授“癌毒”学术思想探析[J]. 中华中医药杂志, 2010, 25(6): 866-869.
[7] 王燕, 陈思思, 江海丽, 等. 李平教授基于“毒生病络”理论治疗结直肠癌临证经验[J]. 世界最新医学信息文摘, 2019, 19(76): 234-235.
[8] 徐玉彬, 张培建, 王超臣. 结直肠癌的病因及发病机制的研究进展[J]. 中华临床医师杂志(电子版), 2015, 9(15): 2912-2915.
[9] 余玉云, 王统华. 结直肠腺瘤性息肉癌变的相关因素研究进展[J]. 临床医学研究与实践, 2024, 9(30): 195-198.
[10] 姚劼赟, 林梅. 结直肠癌致病危险因素的分析及干预[J]. 科技资讯, 2013(10): 237.
[11] Peeters, P.J.H.L., Bazelier, M.T., Leufkens, H.G.M., de Vries, F. and De Bruin, M.L. (2014) The Risk of Colorectal Cancer in Patients with Type 2 Diabetes: Associations with Treatment Stage and Obesity. Diabetes Care, 38, 495-502. [Google Scholar] [CrossRef] [PubMed]
[12] 吕娜, 乔虹. 2型糖尿病患者结直肠癌的发生风险和潜在机制[J]. 中华老年多器官疾病杂志, 2023, 22(8): 620-623.
[13] 吕忠霖, 陈国江. 溃疡性结肠炎癌变机制的研究进展[J]. 中国肿瘤生物治疗杂志, 2016, 23(6): 852-857.
[14] 贾丹丹, 戚文娟, 程莉, 等. 溃疡性结肠炎相关性结直肠癌的危险因素及癌变机制[J]. 现代肿瘤医学, 2014, 22(3): 720-722.
[15] 李艳萍. 溃疡性结肠炎癌变机制的研究及结直肠息肉危险因素分析[D]: [硕士学位论文]. 北京: 北京协和医学院, 2014.
[16] 塔吉姑丽·吐逊, 节阳华. 基于“浊毒-肠道菌群”探讨结直肠癌发病机制[J]. 江西中医药, 2024, 55(9): 7-10.
[17] 栾英桥, 杨佳幸, 陶嫦立, 等. 肠道菌群影响肠道细胞免疫的研究进展[J]. 中国免疫学杂志, 2018, 34(11): 1734-1737, 1742.
[18] 王也, 陈萦晅, 房静远. 早发性结直肠癌危险因素的研究进展[J]. 胃肠病学, 2021, 26(2): 116-120.
[19] Arthur, J.C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J.M., Fan, T., et al. (2012) Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota. Science, 338, 120-123. [Google Scholar] [CrossRef] [PubMed]
[20] Valguarnera, E. and Wardenburg, J.B. (2020) Good Gone Bad: One Toxin Away from Disease for Bacteroides Fragilis. Journal of Molecular Biology, 432, 765-785. [Google Scholar] [CrossRef] [PubMed]
[21] Boleij, A., Hechenbleikner, E.M., Goodwin, A.C., Badani, R., Stein, E.M., Lazarev, M.G., et al. (2014) The Bacteroides Fragilis Toxin Gene Is Prevalent in the Colon Mucosa of Colorectal Cancer Patients. Clinical Infectious Diseases, 60, 208-215. [Google Scholar] [CrossRef] [PubMed]
[22] Purcell, R.V., Pearson, J., Aitchison, A., Dixon, L., Frizelle, F.A. and Keenan, J.I. (2017) Colonization with Enterotoxigenic Bacteroides Fragilis Is Associated with Early-Stage Colorectal Neoplasia. PLOS ONE, 12, e0171602. [Google Scholar] [CrossRef] [PubMed]
[23] Wang, N. and Fang, J. (2023) Fusobacterium Nucleatum, a Key Pathogenic Factor and Microbial Biomarker for Colorectal Cancer. Trends in Microbiology, 31, 159-172. [Google Scholar] [CrossRef] [PubMed]