血清超敏C反应蛋白、淀粉样蛋白A、白介素-6及降钙素原水平与儿童肺炎支原体肺炎治疗反应的相关性分析

Correlation Analysis of Serum High-Sensitivity C-Reactive Protein (hs-CRP), Serum Amyloid A (SAA), Interleukin-6 (IL-6), and Procalcitonin (PCT) Levels with Treatment Response in Children with Mycoplasma pneumoniae Pneumonia

摘要: 目的：本研究聚焦于血清超敏C反应蛋白(hs-CRP)、淀粉样蛋白A (SAA)、白介素-6 (IL-6)及降钙素原(PCT)这四种生物标志物，旨在探讨它们与儿童肺炎支原体肺炎治疗效果及预后之间的关联性，以期为临床提供更为精准的评估工具。方法：收集甘肃徽县妇幼保健院2023年5月~2025年1月120例儿童肺炎支原体肺炎患儿作为研究对象，根据治疗反应分为有效组(n = 90)和无效组(n = 30)。在治疗前、治疗3天及7天三个时间点分别检测了两组患儿血清中的hs-CRP、SAA、IL-6及PCT水平，并深入分析了这些生物标志物的动态变化及其与患儿预后之间的相关性。结果：无效组患儿在治疗前的hs-CRP、SAA、IL-6及PCT水平均显著高于有效组，且这些生物标志物的高水平与患儿的不良预后密切相关。结论：血清hs-CRP、SAA、IL-6及PCT水平与儿童MPP治疗反应密切相关。联合检测这些生物标志物能够更全面地反映患儿的炎症状态和疾病进展。

Abstract: Objective: This study focuses on four biomarkers—serum high-sensitivity C-reactive protein (hs-CRP), serum amyloid A (SAA), interleukin-6 (IL-6), and procalcitonin (PCT)—to investigate their association with treatment efficacy and prognosis in children with Mycoplasma pneumoniae pneumonia (MPP), aiming to provide more precise clinical evaluation tools. Methods: A total of 120 children diagnosed with MPP at Huixian Maternal and Child Health Care Hospital in Gansu Province from May 2023 to January 2025 were enrolled as subjects. Based on treatment response, they were divided into an effective group (n = 90) and an ineffective group (n = 30). Serum levels of hs-CRP, SAA, IL-6, and PCT were measured at three time points (before treatment, 3 days, and 7 days of treatment). Dynamic changes in these biomarkers and their correlation with prognosis were analyzed. Results: The ineffective group exhibited significantly higher baseline levels of hs-CRP, SAA, IL-6, and PCT compared to the effective group. Elevated levels of these biomarkers were closely associated with poor prognosis. Conclusion: Serum hs-CRP, SAA, IL-6, and PCT levels are closely linked to treatment response in pediatric MPP. Combined detection of these biomarkers provides a comprehensive reflection of inflammatory status and disease progression.