自微乳化给药系统：一种新型药物递送技术
Self-Microemulsifying Drug Delivery System: A New-Type Drug Delivery Technology
DOI: 10.12677/hjmce.2025.133028, PDF,   
作者: 唐佳欢：云南大学化学科学与工程学院，云南 昆明；段书宁, 刘紫娴：云南大学生命科学学院，云南 昆明；高加玮, 陈思婧：云南大学政府管理学院，云南 昆明
关键词: 自微乳化给药系统(SMEDDS)；药物递送技术；难溶性药物；生物利用度；制剂评价；Self-Microemulsifying Drug Delivery System (SMEDDS)； Drug Delivery Technology； Poorly-Soluble Drugs； Bioavailability； Pharmaceutical Preparation Evaluation
摘要: 随着制药技术的不断发展，新型药物剂型不断涌现，以满足日益增长的临床用药需求。自微乳化给药系统(Self-microemulsifying drug delivery systems, SMEDDS)作为一种新型药物剂型，具有提高药物溶解度、促进药物吸收、增强药物稳定性等诸多优势。本文详细阐述了自微乳化给药系统的基本概念、组成与制备、作用机制、体内外评价方法，同时对其应用实例及发展前景进行了探讨，旨在为该剂型的进一步研究与开发提供参考。
Abstract: With the continuous development of pharmaceutical technologies, new types of drug dosage forms have emerged ceaselessly to meet the growing clinical demands for medications. The Self-Microemulsifying Drug Delivery System (SMEDDS), as a new type of drug dosage form, possesses numerous advantages such as enhancing drug solubility, promoting drug absorption, and strengthening drug stability. This paper elaborates in detail on the basic concept, composition and preparation, mechanism of action, in vitro and in vivo evaluation methods of the self-microemulsifying drug delivery system. Meanwhile, it explores its application examples and development prospects, aiming to provide references for the further research and development of this dosage form.
文章引用：唐佳欢, 段书宁, 高加玮, 刘紫娴, 陈思婧. 自微乳化给药系统：一种新型药物递送技术[J]. 药物化学, 2025, 13(3): 266-276. https://doi.org/10.12677/hjmce.2025.133028

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