ELMO1和MTA1在肺癌中的水平及其临床意义
Serum Level and Clinical Significance of ELMO1 and MTA1 in Lung Cancer
DOI: 10.12677/md.2025.154061, PDF,    科研立项经费支持
作者: 慕玉东, 贺 林：西安交通大学医学院附属陕西省肿瘤医院，陕西 西安；张 涛*：西安交通大学医学院附属西安市中心医院，陕西 西安
关键词: ELMO1；MTA1；肺癌；ELMO1； MTA1； Lung Cancer
摘要: 目的：探讨ELMO1和MTA1在肺癌中的水平及其临床意义。方法：选取从2023年1月至2023年12月在我院就诊的100例肺癌患者和100健康体检人员。测定血清及组织ELMO1和MTA1水平，分析在肺癌中的相关性。结果：肺癌患者的血清ELMO1和MTA1水平明显高于对照组(P < 0.05)；肺癌组织中ELMO1和MTA1表达水平高于癌旁组织，差异无统计学意义；ELMO1和MTA1表达在肺癌中呈正相关。结论：血清ELMO1和MTA1水平与肺癌相关，而且ELMO1表达与MTA1表达在肺癌中呈正相关，检测ELMO1和MTA1可为肺癌的筛查、早期诊断及精准治疗提供新的依据。
Abstract: Objective: To investigate the relationship between the level of ELMO1 and MTA1 and Lung cancer. Methods: From January 2023 to December 2023, 100 lung cancer patients after surgery and 100 health people as control group were elected. The levels of engulfment and cell motility proteins 1 (ELMO1) and metastasis-associated gene 1 (MTA1) were measured, and analyzed the relationship in lung cancer. Results: The serum levels of ELMO1 and MTA1 in lung cancer patients were significantly higher than the control group (P < 0.05). The tissue levels of ELMO1 and MTA1 in lung cancer patients were significantly higher than paraneoplastic tissue of lung cancer patients, but the difference was not statistically significant. ELMO1 levels correlated positively with MTA1 levels in lung cancer tissue. Conclusion: The levels of ELMO1 and MTA1 were related to lung cancer, and ELMO1 levels correlated positively with serum MTA1 levels. Through monitoring the levels of ELMO1 and MTA1, the methods should provide a new theoretical basis for early diagnosis and screening of lung cancer and accurate treatment.
文章引用：慕玉东, 贺林, 张涛. ELMO1和MTA1在肺癌中的水平及其临床意义[J]. 医学诊断, 2025, 15(4): 453-458. https://doi.org/10.12677/md.2025.154061

参考文献

[1] Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A. and Jemal, A. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. [Google Scholar] [CrossRef] [PubMed]
[2] Siegel, R.L., Miller, K.D. and Jemal, A. (2020) Cancer Statistics, 2020. CA: A Cancer Journal for Clinicians, 70, 7-30. [Google Scholar] [CrossRef] [PubMed]
[3] Wang, Y., Xu, X., Pan, M. and Jin, T. (2016) ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis. Journal of Cancer, 7, 973-983. [Google Scholar] [CrossRef] [PubMed]
[4] Makino, Y., Tsuda, M., Ichihara, S., Watanabe, T., Sakai, M., Sawa, H., et al. (2006) Elmo1 Inhibits Ubiquitylation of Dock180. Journal of Cell Science, 119, 923-932. [Google Scholar] [CrossRef] [PubMed]
[5] 谢海健. MTA1基因的研究概况[J]. 包头医学, 2013, 37(3): 136-139.
[6] Gao, S., Li, N., Wang, S., Zhang, F., Wei, W., Li, N., et al. (2020) Lung Cancer in People’s Republic of China. Journal of Thoracic Oncology, 15, 1567-1576. [Google Scholar] [CrossRef] [PubMed]
[7] Gumienny, T.L., Brugnera, E., Tosello-Trampont, A., Kinchen, J.M., Haney, L.B., Nishiwaki, K., et al. (2001) CED-12/ELMO, a Novel Member of the CrkII/Dock180/Rac Pathway, Is Required for Phagocytosis and Cell Migration. Cell, 107, 27-41. [Google Scholar] [CrossRef] [PubMed]
[8] East, M.P., Bowzard, J.B., Dacks, J.B. and Kahn, R.A. (2012) ELMO Domains, Evolutionary and Functional Characterization of a Novel GTPase-Activating Protein (GAP) Domain for Arf Protein Family GTPases. Journal of Biological Chemistry, 287, 39538-39553. [Google Scholar] [CrossRef] [PubMed]
[9] Brzostowski, J.A., Fey, P., Yan, J., Isik, N. and Jin, T. (2009) The Elmo Family Forms an Ancient Group of Actin-Regulating Proteins. Communicative & Integrative Biology, 2, 337-340. [Google Scholar] [CrossRef] [PubMed]
[10] Li, H., Yang, L., Fu, H., Yan, J., Wang, Y., Guo, H., et al. (2013) Association between Gαi2 and Elmo1/Dock180 Connects Chemokine Signalling with Rac Activation and Metastasis. Nature Communications, 4, Article No. 1706. [Google Scholar] [CrossRef] [PubMed]
[11] Zhang, B., Shi, L., Lu, S., Sun, X., Liu, Y., Li, H., et al. (2015) Autocrine IL-8 Promotes F-Actin Polymerization and Mediate Mesenchymal Transition via ELMO1-NF-Κb-Snail Signaling in Glioma. Cancer Biology & Therapy, 16, 898-911. [Google Scholar] [CrossRef] [PubMed]
[12] Kong, D., Zhou, H., Neelakantan, D., Hughes, C.J., Hsu, J.Y., Srinivasan, R.R., et al. (2020) VEGF-C Mediates Tumor Growth and Metastasis through Promoting EMT-Epithelial Breast Cancer Cell Crosstalk. Oncogene, 40, 964-979. [Google Scholar] [CrossRef] [PubMed]
[13] Gururaj, A.E., Singh, R.R., Rayala, S.K., Holm, C., den Hollander, P., Zhang, H., et al. (2006) MTA1, a Transcriptional Activator of Breast Cancer Amplified Sequence 3. Proceedings of the National Academy of Sciences, 103, 6670-6675. [Google Scholar] [CrossRef] [PubMed]
[14] Liu, J., Li, C., Wang, J., Xu, D., Wang, H., Wang, T., et al. (2020) Chromatin Modifier MTA1 Regulates Mitotic Transition and Tumorigenesis by Orchestrating Mitotic mRNA Processing. Nature Communications, 11, Article No. 4455. [Google Scholar] [CrossRef] [PubMed]
[15] Sasaki, H., Moriyama, S., Nakashima, Y., Kobayashi, Y., Yukiue, H., Kaji, M., et al. (2002) Expression of the MTA1 mRNA in Advanced Lung Cancer. Lung Cancer, 35, 149-154. [Google Scholar] [CrossRef] [PubMed]
[16] Zhu, W., Li, G., Guo, H., et al. (2017) Clinicopathological Significance of MTA1 Expression in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis. Asian Pacific Journal of Cancer Prevention, 18, 2903-2909.
[17] Deng, Y. and Yu, J. (2020) MTA1 Is an Indicator of Prognosis in Chinese Patients with Lung Adenocarcinoma. Translational Cancer Research, 9, 1625-1629. [Google Scholar] [CrossRef] [PubMed]
[18] Abu-Thuraia, A., Gauthier, R., Chidiac, R., Fukui, Y., Screaton, R.A., Gratton, J., et al. (2015) Axl Phosphorylates Elmo Scaffold Proteins to Promote Rac Activation and Cell Invasion. Molecular and Cellular Biology, 35, 76-87. [Google Scholar] [CrossRef] [PubMed]
[19] Zhong, J., Ma, L. and Li, L. (2014) Postoperative Therapy Options for Hepatocellular Carcinoma. Scandinavian Journal of Gastroenterology, 49, 649-661. [Google Scholar] [CrossRef] [PubMed]
[20] Søes, S., Daugaard, I.L., Sørensen, B.S., Carus, A., Mattheisen, M., Alsner, J., et al. (2014) Hypomethylation and Increased Expression of the Putative Oncogene ELMO3 Are Associated with Lung Cancer Development and Metastases Formation. Oncoscience, 1, 367-374. [Google Scholar] [CrossRef] [PubMed]