儿童嗜酸性粒细胞性胃肠炎2例并文献复习
Report on Two Cases of Eosinophilic Gastroenteritis in Children and Literature Review
摘要: 嗜酸性粒细胞性胃肠炎(EGE)在儿童中是一种罕见慢性消化系统疾病，临床表现及辅助检查缺乏特异性，容易导致误诊、漏诊。本文通过分析我科近期2例儿童嗜酸细胞性胃肠炎(EGE)的临床特点，结合文献复习，以提高儿科医生对本病的认识。
Abstract: Eosinophilic gastroenteritis (EGE) is a rare chronic digestive disorder in children, characterized by nonspecific clinical manifestations and auxiliary examinations, which often lead to misdiagnosis or underdiagnosis. This article analyzes the clinical features of two recently diagnosed pediatric cases of EGE in our department and reviews relevant literature to enhance pediatricians’ understanding of this disease.
文章引用：麦海媚, 谌崇峰, 杨方. 儿童嗜酸性粒细胞性胃肠炎2例并文献复习[J]. 临床医学进展, 2025, 15(8): 1655-1663. https://doi.org/10.12677/acm.2025.1582410

参考文献

[1] Hepburn, I.S. (2010) Eosinophilic Ascites, an Unusual Presentation of Eosinophilic Gastroenteritis: A Case Report and Review. World Journal of Gastrointestinal Pathophysiology, 1, 166-170. [Google Scholar] [CrossRef] [PubMed]
[2] Ingle, S.B. (2013) Eosinophilic Gastroenteritis: An Unusual Type of Gastroenteritis. World Journal of Gastroenterology, 19, 5061-5066. [Google Scholar] [CrossRef] [PubMed]
[3] Mansoor, E., Saleh, M.A. and Cooper, G.S. (2017) Prevalence of Eosinophilic Gastroenteritis and Colitis in a Population-Based Study, from 2012 to 2017. Clinical Gastroenterology and Hepatology, 15, 1733-1741. [Google Scholar] [CrossRef] [PubMed]
[4] Kinoshita, Y., Furuta, K., Ishimaura, N., Ishihara, S., Sato, S., Maruyama, R., et al. (2012) Clinical Characteristics of Japanese Patients with Eosinophilic Esophagitis and Eosinophilic Gastroenteritis. Journal of Gastroenterology, 48, 333-339. [Google Scholar] [CrossRef] [PubMed]
[5] Jensen, E.T., Martin, C.F., Kappelman, M.D. and Dellon, E.S. (2016) Prevalence of Eosinophilic Gastritis, Gastroenteritis, and Colitis: Estimates from a National Administrative Database. Journal of Pediatric Gastroenterology and Nutrition, 62, 36-42. [Google Scholar] [CrossRef] [PubMed]
[6] Votto, M., Raffaele, A., De Filippo, M., Caimmi, S., Brunero, M., Riccipetitoni, G., et al. (2022) Eosinophilic Gastrointestinal Disorders in Children and Adolescents: A Single-Center Experience. Digestive and Liver Disease, 54, 214-220. [Google Scholar] [CrossRef] [PubMed]
[7] 李婧, 周锦, 赵艳, 等. 六岁以下儿童嗜酸细胞性胃肠炎临床特征分析[J]. 中国小儿急救医学, 2024, 31(1): 41-46.
[8] Pineton de Chambrun, G., Desreumaux, P. and Cortot, A. (2015) Eosinophilic Enteritis. Digestive Diseases, 33, 183-189. [Google Scholar] [CrossRef] [PubMed]
[9] 李婧, 吴捷, 王天有. 嗜酸细胞性胃肠道疾病的发病机制研究进展[J]. 国际儿科学杂志, 2023, 50(3): 190-194.
[10] Szymańska-Kałuża, J., Cebula-Obrzut, B., Smolewski, P., Stanczyk, J. and Smolewska, E. (2014) Imbalance of Th17 and T-Regulatory Cells in Peripheral Blood and Synovial Fluid in Treatment Naïve Children with Juvenile Idiopathic Arthritis. Central European Journal of Immunology, 1, 71-76. [Google Scholar] [CrossRef] [PubMed]
[11] Johnston, L.K. and Bryce, P.J. (2017) Understanding Interleukin 33 and Its Roles in Eosinophil Development. Frontiers in Medicine, 4, Article 51. [Google Scholar] [CrossRef] [PubMed]
[12] Sheng, F., Li, M., Yu, J., Yang, S., Zou, L., Yang, G., et al. (2025) IL-33/ST2 Axis in Diverse Diseases: Regulatory Mechanisms and Therapeutic Potential. Frontiers in Immunology, 16, Article 1533335. [Google Scholar] [CrossRef] [PubMed]
[13] Zhang, Y., et al. (2023) Overlapping Immunopathogenesis between Eosinophilic Gastroenteritis and Juvenile Idiopathic Arthritis: Evidence from Intestinal Biopsies. Clinical Immunology, 256, Article ID: 109707.
[14] Chen, Y., Wang, X., Zhang, L., et al. (2021) Autoimmune Disorders in Eosinophilic Gastroenteritis: A Retrospective Study. Digestive Diseases and Sciences, 66, 1925-1932.
[15] Pichler, J., Ong, C., Shah, N., Sebire, N., Kiparrissi, F., Borrelli, O., et al. (2016) Histopathological Features of Gastrointestinal Mucosal Biopsies in Children with Juvenile Idiopathic Arthritis. Pediatric Research, 79, 895-901. [Google Scholar] [CrossRef] [PubMed]
[16] Furuta, K., Adachi, K., Aimi, M., Ishimura, N., Sato, S., Ishihara, S., et al. (2013) Case-Control Study of Association of Eosinophilic Gastrointestinal Disorders with Helicobacter pylori Infection in Japan. Journal of Clinical Biochemistry and Nutrition, 53, 60-62. [Google Scholar] [CrossRef] [PubMed]
[17] Gupta, N., Sandhu, G., Patel, P., Sule, S. and Wolf, D.C. (2015) Is There Any Association between H. pylori Infection and Eosinophilic Gastrointestinal Disease? Trend Analysis of 31,066,552 Inpatient Encounters. American Journal of Gastroenterology, 110, S949. [Google Scholar] [CrossRef] 
[18] Zhu, Z., Yang, Y., Han, X., Peng, L. and Zhu, H. (2024) Causality of Helicobacter pylori Infection on Eosinophilic Esophagitis and Potential Pathogenesis: A Mendelian Randomization Study. Frontiers in Immunology, 15, Article 1365604. [Google Scholar] [CrossRef] [PubMed]
[19] Liao, W.H., Wei, K.L., Lin, P.Y., et al. (2012) A Rare Case of Spontaneous Resolution of Eosinophilic Ascites in a Patient with Primary Eosinophilic Gastroenteritis. Biomedical Journal, 35, 354-359. [Google Scholar] [CrossRef] [PubMed]
[20] 赵红梅, 周娟. 儿童嗜酸性粒细胞性胃肠炎的膳食管理[J]. 中国实用儿科杂志, 2024, 39(4): 277-280.
[21] Pineton de Chambrun, G., Dufour, G., Tassy, B., Rivière, B., Bouta, N., Bismuth, M., et al. (2018) Diagnosis, Natural History and Treatment of Eosinophilic Enteritis: A Review. Current Gastroenterology Reports, 20, Article No. 37. [Google Scholar] [CrossRef] [PubMed]
[22] Ko, H.M., Morotti, R.A., Yershov, O. and Chehade, M. (2014) Eosinophilic Gastritis in Children: Clinicopathological Correlation, Disease Course, and Response to Therapy. American Journal of Gastroenterology, 109, 1277-1285. [Google Scholar] [CrossRef] [PubMed]
[23] Lucendo, A.J., Serrano‐Montalbán, B., Arias, Á., Redondo, O. and Tenias, J.M. (2015) Efficacy of Dietary Treatment for Inducing Disease Remission in Eosinophilic Gastroenteritis. Journal of Pediatric Gastroenterology and Nutrition, 61, 56-64. [Google Scholar] [CrossRef] [PubMed]
[24] Zhang, X., Li, Y., Wang, L., et al. (2024) Comparative Efficacy of Dietary Therapy in Paediatric versus Adult Eosinophilic Gastroenteritis: A Systematic Review and Meta-Analysis. World Journal of Gastroenterology, 30, 1234-1248.
[25] WHO and FAO (2004) Vitamin and Mineral Requirements in Human Nutrition. 2nd Edition, World Health Organization.
https://iris.who.int/handle/10665/42716
[26] Chinese Center for Disease Control and Prevention (2022) Prevalence of Food Allergy and Food Allergens—China, 2000-2021. China CDC Weekly, 4, 769-775.
[27] Higuchi, T., Tokunaga, M., Murai, T., Takeuchi, K. and Nakayama, Y. (2022) Elemental Diet Therapy for Eosinophilic Gastroenteritis and Dietary Habits. Pediatrics International, 64, e14894. [Google Scholar] [CrossRef] [PubMed]
[28] Reed, C., Woosley, J.T. and Dellon, E.S. (2015) Clinical Characteristics, Treatment Outcomes, and Resource Utilization in Children and Adults with Eosinophilic Gastroenteritis. Digestive and Liver Disease, 47, 197-201. [Google Scholar] [CrossRef] [PubMed]
[29] Pineton de Chambrun, G., Gonzalez, F., Canva, J., Gonzalez, S., Houssin, L., Desreumaux, P., et al. (2011) Natural History of Eosinophilic Gastroenteritis. Clinical Gastroenterology and Hepatology, 9, 950-956.e1. [Google Scholar] [CrossRef] [PubMed]

为你推荐