脂代谢紊乱在糖尿病肾病中作用机制的研究进展
Research Progress on the Mechanism of Lipid Metabolism Disorders in Diabetic Nephropathy
DOI: 10.12677/jcpm.2025.44451, PDF,   
作者: 张 瑜, 刘 卉:西安医学院第一附属医院风湿免疫科,陕西 西安
关键词: 糖尿病肾病脂肪酸代谢胆固醇代谢脂滴铁死亡Diabetic Nephropathy Fatty Acid Metabolism Cholesterol Metabolism Lipid Droplet Ferroptosis
摘要: 糖尿病肾病(Diabetic nephropathy, DN)是糖尿病最常见并发症,是全球引起慢性肾脏病和终末期肾脏病的主要原因之一。DN的发病机制复杂,其中脂代谢紊乱及“脂质肾毒性”是DN发病及进展的重要因素之一。本文从脂代谢中的脂肪酸及胆固醇代谢紊乱、脂滴聚集以及其他DN发病机制方面进行阐述,旨在为今后临床防治DN提供理论参考依据。
Abstract: Diabetic Nephropathy (DN) is one of the most common complications of diabetes, and it is the main cause of Chronic Kidney Disease (CKD) and End-Stage Kidney Disease (ESKD) worldwide. The pathogenesis of DN is relatively complex, among which lipid metabolism disorders and “lipid nephrotoxicity” are important factors for the onset and progression of DN. This article elaborates on the metabolic disorders of fatty acids and cholesterol in lipid metabolism, lipid droplet aggregation, and other mechanisms of DN, aiming to provide theoretical reference for the future clinical prevention and treatment of DN.
文章引用:张瑜, 刘卉. 脂代谢紊乱在糖尿病肾病中作用机制的研究进展[J]. 临床个性化医学, 2025, 4(4): 325-332. https://doi.org/10.12677/jcpm.2025.44451

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