颗粒酶-K对高血压调控作用的研究进展

Research Progress on the Regulatory Role of Granzyme-K in Hypertension

摘要: 高血压是严重威胁人类健康的重大疾病，既往研究主要关注于RAS激活、交感增强及血管平滑肌细胞(VSMC)功能异常。最近研究表明，在高血压发生发展过程中，机体免疫系统的异常激活及慢性炎症反应是导致高血压发生发展的关键因素。其介导的CD8 < sup > + < /sup > T细胞活化、血管内皮损伤及免疫衰老进程，可能通过重塑血管微环境、激活炎症信号网络参与高血压的发生发展。尽管现有文献尚未直接探讨GZMK与高血压的关联，但基于GZMK在炎症组织浸润、血管内皮损伤及衰老免疫中的核心作用，深入剖析其潜在的调控路径将为高血压的精准治疗提供新靶点。

Abstract: Hypertension is a major disease that seriously threatens human health. Previous studies have mainly focused on RAS activation, sympathetic hyperactivity, and abnormal functions of vascular smooth muscle cells (VSMCs). Recent studies have shown that abnormal activation of the body’s immune system and chronic inflammatory responses are key factors contributing to the occurrence and development of hypertension. The mediated CD8 < sup > + < /sup > T cell activation, vascular endothelial injury, and immunosenescence process may be involved in the occurrence and development of hypertension by remodeling the vascular microenvironment and activating the inflammatory signaling network. Although existing literature has not directly explored the association between GZMK and hypertension, based on the core role of GZMK in inflammatory tissue infiltration, vascular endothelial injury, and aging immunity, in-depth analysis of its potential regulatory pathways will provide new targets for the precise treatment of hypertension.