基于“谱效关联”的土家药百棒七不同入药部位药效基础及抗RA机制研究进展

Research Progress on the Pharmacological Basis and Anti-RA Mechanism of Different Medicinal Parts of Bai Bang Qi Based on “Spectral Effect Association” in Tujia Medicine

摘要: 百棒七作为土家族传统医药体系中的特色民族药，其药用价值在现代科学研究视角下正被深入挖掘。该植物以根、茎、叶等不同部位入药，传统应用中已显现出显著的抗炎镇痛特性，尤其在治疗类风湿型关节炎这一领域展现出独特优势。近年来，随着中药现代化研究技术的突破，“谱效关联”分析方法成为解析其药效物质基础的核心工具，通过构建化学成分谱与药效学指标的关联模型，能够系统比较不同入药部位中活性成分的组成差异及作用强度。研究证实，百棒七各部位含有三萜皂苷、黄酮类、酚酸类等多种活性成分，可能是其发挥抗RA作用的关键药效物质，这些成分通过调控相关信号通路，抑制炎症因子释放，从而减轻关节炎症和骨破坏。本文系统阐述百棒七不同部位临床应用、化学成分、RA机制及谱效关系的最新研究进展，不仅为阐明该民族药的药效物质基础提供了科学依据，也为其他传统药物的现代化研究和开发提供了重要参考。

Abstract: As a distinctive ethnic medicinal herb in the Tujia traditional medicine system, Bai Bang Qi is being increasingly explored for its therapeutic value through modern scientific research. The plant’s various medicinal parts including roots, stems, and leaves have demonstrated remarkable anti-inflammatory and analgesic properties in traditional applications, particularly showing unique advantages in treating rheumatoid arthritis. Recent breakthroughs in modernization of traditional Chinese medicine research have made “spectroactivity correlation” analysis a core tool for deciphering its pharmacological basis. By establishing models linking chemical composition profiles with pharmacodynamic indicators, researchers can systematically compare differences in active component compositions and potency across medicinal parts. Studies confirm that Bai Bang Qi contains triterpene saponins, flavonoids, phenolic acids, and other bioactive compounds, which may be key contributors to its anti-RA effects. These components regulate signaling pathways and suppress inflammatory factor release, thereby alleviating joint inflammation and bone destruction. This paper systematically reviews the latest research progress on clinical applications, chemical composition, RA mechanisms, and spectral-effect relationships of Bai Bang Qi across different parts. It not only provides scientific evidence for elucidating the pharmacological basis of this ethnic medicine but also offers valuable references for modernizing and developing other traditional medicinal resources.