姜黄素干预阿尔茨海默病(AD)的多靶点机制：从Aβ清除、Tau调控到神经炎症抑制
Multi-Target Mechanism of Curcumin Intervention in Alzheimer’s Disease (AD): From Aβ Clearance and Tau Regulation to Neuroinflammatory Inhibition
DOI: 10.12677/ns.2025.149205, PDF,    科研立项经费支持
作者: 何明颐*, 张建安*, 贾云飞, 谢海蝶, 郑 瑶, 马瑜洁, 张艺馨, 焦燕琴, 翁佳昇, 王平义#：西藏民族大学医学院/西藏自治区高原胃肠病临床医学研究中心，陕西 咸阳；孙若豪：首都医科大学附属北京天坛医院神经外科，北京；国家神经系统疾病临床医学研究中心，北京
关键词: 阿尔茨海默病(AD)；姜黄素；Aβ清除；Tau调控；神经炎症抑制；Alzheimer’s Disease (AD)； Curcumin； Aβ Clearance； Tau Regulation； Neuroinflammatory Inhibition
摘要: 随着全球老龄化进程的持续加剧，神经退行性疾病阿尔茨海默病(AD)的患病率呈现显著上升趋势，该疾病以渐进性认知功能障碍为主要临床特征，因此对疾病的机制和治疗方法的探究极其必要。传统治疗使用的化学药物存在着作用靶点单一、损伤相关神经元等缺陷，而中药治疗恰好可以弥补这一不足。作为从姜黄中提取的天然活性成分，姜黄素凭借其显著的抗炎特性、抗氧化效应以及抑制肿瘤生长的多重药理功能，展现出通过调控多靶点分子通路来改善阿尔兹海默病病理进程的潜在治疗价值。本文主要聚焦于姜黄素从Aβ清除、Tau调控到神经炎症抑制这几方面治疗阿尔茨海默病(AD)的作用机制，并在此基础上归纳姜黄素目前存在的稳定性较差、肠内吸收率较低等短板及解决方向。
Abstract: With the continuous intensification of global aging, the prevalence of neurodegenerative disease Alzheimer’s disease (AD) is showing a significant upward trend, which is characterized by progressive cognitive dysfunction as the main clinical feature, so it is extremely necessary to explore the mechanism and treatment of the disease. Traditional chemical drugs used in treatment suffer from limitations such as single-target specificity and potential damage to related neurons. Traditional Chinese medicine (TCM) offers a complementary solution to these shortcomings. As a natural active ingredient extracted from turmeric, curcumin has shown potential therapeutic value in improving the pathological progression of Alzheimer’s disease by modulating multi-target molecular pathways due to its significant anti-inflammatory properties, antioxidant effects, and multiple pharmacological functions that inhibit tumor growth. This paper mainly focuses on the mechanism of curcumin in the treatment of Alzheimer’s disease (AD) from Aβ clearance, Tau regulation to neuroinflammatory inhibition, and on this basis, summarizes the current shortcomings and solutions of curcumin such as poor stability and low intestinal absorption rate.
文章引用：何明颐, 张建安, 孙若豪, 贾云飞, 谢海蝶, 郑瑶, 马瑜洁, 张艺馨, 焦燕琴, 翁佳昇, 王平义. 姜黄素干预阿尔茨海默病(AD)的多靶点机制：从Aβ清除、Tau调控到神经炎症抑制[J]. 护理学, 2025, 14(9): 1544-1555. https://doi.org/10.12677/ns.2025.149205

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