HPR、PLR、NLR、CEA在结直肠癌中的研究进展
Research Progress of HPR, PLR, NLR and CEA in Colorectal Cancer
摘要: 我国结直肠癌带来的疾病负担极为沉重，而早期筛查与诊断对于改善患者预后有着至关重要的意义。目前，结肠镜检查因具有侵入性，血清癌胚抗原(CEA)则因特异性不足，二者在临床应用中均受到一定限制。近年来，血红蛋白与血小板比值(HPR)、血小板与淋巴细胞比值(PLR)及中性粒细胞与淋巴细胞比值(NLR)作为炎症相关生物标志物，逐渐成为该领域的研究热点。本文对HPR、PLR、NLR及CEA在结直肠癌中的研究进展进行综述，目的是为结直肠癌的早期发现、病情评估、预后判断以及治疗监测等方面提供新的思路和方向，以期为临床实践提供更有价值的参考，助力改善结直肠癌患者的诊疗效果和生存质量。
Abstract: The burden of disease caused by colorectal cancer in China is extremely heavy, and early screening and diagnosis are of great significance for improving the prognosis of patients. At present, colonoscopy is invasive, and serum carcinoembryonic antigen (CEA) is not specific enough, both of which are limited in clinical application. In recent years, hemoglobin-to-platelet ratio (HPR), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have gradually become research hotspots in this field as inflammation-related biomarkers. This article reviews the research progress of HPR, PLR, NLR and CEA in colorectal cancer. The purpose is to provide new ideas and directions for early detection, disease assessment, prognosis judgment and treatment monitoring of colorectal cancer, so as to provide more valuable reference for clinical practice and help improve the diagnosis and treatment effect and quality of life of patients with colorectal cancer.
文章引用：林心艳, 周喜汉, 王衍鑫. HPR、PLR、NLR、CEA在结直肠癌中的研究进展[J]. 临床医学进展, 2025, 15(9): 169-177. https://doi.org/10.12677/acm.2025.1592471

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