脑卒中的肠道菌群分析

Analysis of Gut Microbiota in Stroke

摘要: 脑卒中(Stroke)是一种脑部血管循环障碍疾病，通常表现为脑血流的短暂或永久性停止，可能导致永久性的神经功能缺损、痴呆甚至死亡，是目前致死率最高的疾病之一。近年来的研究表明，肠道菌群与脑卒中的发生和发展密切相关。肠道微生物群被认为与脑卒中的发病机制存在潜在联系。本研究旨在通过对不同并发症的脑卒中患者进行16S rRNA扩增子测序分析，探讨肠道菌群与脑卒中发病之间的关系。通过多样性分析、菌群组成差异分析和代谢通路分析，研究结果表明，脑卒中患者的肠道菌群与健康对照组存在显著差异。尤其是在普雷沃氏菌属(Prevotella)和弯曲菌门(Campilobacterota)的相对丰度上，脑卒中患者表现出明显的变化。本文为脑卒中相关肠道菌群的潜在生物标志物提供了新的思路，并为后续的脑卒中治疗和预防提供了理论依据。

Abstract: Stroke is a cerebrovascular disorder characterized by the transient or permanent cessation of cerebral blood flow, often leading to irreversible neurological deficits, dementia, or even death; it remains one of the leading causes of mortality worldwide. Emerging evidence indicates a close relationship between the gut microbiota and both the onset and progression of stroke. The gut microbiota community is thought to be mechanistically linked to stroke pathogenesis. This study uses 16S rRNA amplicon sequencing to profile the gut microbiota of stroke patients with different complications, aiming to clarify the relationship between microbial composition and stroke pathogenesis. Diversity metrics, differential taxonomic analyses, and metabolic pathway predictions revealed pronounced differences between patients and healthy controls. Notably, the relative abundances of Prevotella (genus) and the phylum Campylobacterota were markedly altered in the stroke cohort. These findings provide new insights into potential microbial biomarkers related to stroke and offer a theoretical basis for future strategies in stroke prevention and therapy.