Ki-67、CAIX、VEGF三种生物标志物与肾透明细胞癌的相关研究进展
Research Progress on the Correlation between Three Biomarkers, Ki-67, CAIX and VEGF and Clear Cell Renal Cell Carcinoma
DOI: 10.12677/acm.2025.1592493, PDF,   
作者: 马锦容, 武超越, 刘振华, 胡耀强：延安大学延安医学院，陕西 延安；靳永胜*：延安大学附属医院泌尿外科，陕西 延安
关键词: 肾透明细胞癌；Ki-67；CAIX；VEGF；生物标志物；Clear Cell Renal Cell Carcinoma； Ki-67； CAIX； VEGF； Biomarkers
摘要: 肾透明细胞癌(ccRCC)是最常见的肾癌亚型，其发病机制复杂且预后差异显著，给临床治疗带来了挑战。近年来，生物标志物在ccRCC的诊断、治疗及预后评估中逐渐显现出重要价值。特别是Ki-67、CAIX和VEGF这三种生物标志物，已经被广泛研究并应用于临床实践。Ki-67作为细胞增殖的指标，其表达水平与肿瘤的增殖活性及恶性程度密切相关；CAIX则在肾癌细胞的缺氧适应中发挥重要作用，其表达水平与肿瘤的侵袭性和预后密切相关；VEGF则是肿瘤血管生成的重要因子，其水平不仅影响肿瘤生长，还与患者的生存期相关。本文将综述这三种生物标志物在ccRCC中的表达特征及作用机制，旨在为ccRCC的精准诊疗提供理论依据，推动该领域的进一步研究和发展。
Abstract: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma. Its pathogenesis is complex and the prognosis varies significantly, which brings challenges to clinical treatment. In recent years, biomarkers have gradually demonstrated significant value in the diagnosis, treatment and prognosis evaluation of ccRCC. Especially the three biomarkers, Ki-67, CAIX and VEGF, have been widely studied and applied in clinical practice. Ki-67, as an indicator of cell proliferation, its expression level is closely related to the proliferative activity and malignancy degree of tumors. CAIX plays an important role in the hypoxia adaptation of renal cancer cells, and its expression level is closely related to the invasiveness and prognosis of the tumor. VEGF is an important factor in tumor angiogenesis. Its level not only affects tumor growth but is also related to the survival period of patients. This article will review the expression characteristics and mechanism of action of these three biomarkers in ccRCC, aiming to provide a theoretical basis for the precise diagnosis and treatment of ccRCC and promote further research and development in this field.
文章引用：马锦容, 武超越, 刘振华, 胡耀强, 靳永胜. Ki-67、CAIX、VEGF三种生物标志物与肾透明细胞癌的相关研究进展[J]. 临床医学进展, 2025, 15(9): 326-334. https://doi.org/10.12677/acm.2025.1592493

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