基于壳聚糖的纳米载体在特应性疾病治疗中的研究进展
Advances in Chitosan-Based Nanocarriers in the Treatment of Atopic Diseases
DOI: 10.12677/tcm.2025.149555, PDF,    科研立项经费支持
作者: 李 璇*, 邓思瑶, 唐维康, 刘慧霞#：塔里木大学医学院，新疆 阿拉尔；张 蓉, 易 欣：成都中医药大学临床医学院，四川 成都
关键词: 壳聚糖；纳米载体；特应性疾病；综述；Chitosan； Nanocarrier； Atopic Diseases； Review
摘要: 壳聚糖及其衍生物具有优异的生物相容性、可降解性和低免疫原性，兼具抗氧化、免疫调节和抗菌等多种生物活性。在药物递送领域，纳米载体技术显著改善了药物的水溶性、靶向性和安全性。目前研究的壳聚糖纳米递送系统主要包括：纳米颗粒(良好的亲水性和生物相容性)、静电纺纳米纤维(提升药物溶解度和渗透性)、纳米凝胶(高持水性)以及壳聚糖修饰脂质体(增强靶向性和组织穿透力)。这些载体系统凭借其显著的抗炎、抗过敏特性和高生物利用度，为哮喘、变应性鼻炎等特应性疾病的治疗提供了高效低毒的新策略，展现出广阔的临床应用前景。本文重点探讨壳聚糖纳米载体在特应性疾病治疗中的应用机制。
Abstract: Chitosan and its derivatives have excellent biocompatibility, degradability, and low immunogenicity, and combine a variety of biological activities, such as antioxidant, immunomodulatory, and antibacterial. In the field of drug delivery, nanocarrier technology has significantly improved the water solubility, targeting and safety of drugs. The chitosan nanodelivery systems studied so far mainly include: nanoparticles (good hydrophilicity and biocompatibility), electrostatically spun nanofibers (enhanced drug solubility and permeability), nanogels (high water-holding capacity), and chitosan-modified liposomes (enhanced targeting and tissue penetration). With their remarkable anti-inflammatory and anti-allergic properties and high bioavailability, these carrier systems provide a new strategy of high efficiency and low toxicity for the treatment of atopic diseases, such as asthma and allergic rhinitis, and show broad prospects for clinical applications. This paper focuses on the application mechanism of chitosan nanocarriers in the treatment of atopic diseases.
文章引用：李璇, 张蓉, 邓思瑶, 唐维康, 易欣, 刘慧霞. 基于壳聚糖的纳米载体在特应性疾病治疗中的研究进展[J]. 中医学, 2025, 14(9): 3805-3813. https://doi.org/10.12677/tcm.2025.149555

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