情境教学法在医药化学课程中的应用研究——以“药物代谢反应中的氧化还原过程”为例

Research on the Application of Situational Teaching Method in MedicinalChemistry Courses—Taking “Redox Processes in Drug Metabolism Reactions” as an Example

摘要: 本研究以医药化学课程中“药物代谢反应中的氧化还原过程”为切入点，构建“肝脏微粒体酶催化药物氧化”模拟情境，结合3D分子模型与临床药物不良反应案例，采用角色扮演法实施教学。通过课堂观察记录与课后概念图评分，验证情境教学法对学生知识情境化迁移能力与应用能力的提升效果。结果显示，实验组学生在概念图结构完整性、临床案例分析准确性等方面显著优于传统教学班(p < 0.05)，表明情境教学法能有效促进医药化学知识的深度理解与临床应用能力。

Abstract: This study takes “Redox processes in drug metabolism reactions” in the medicinal chemistry curriculum as the entry point, constructs a simulated scenario of “liver microsomal enzyme-catalyzed drug oxidation”, combines 3D molecular models with clinical cases of adverse drug reactions, and employs the role-playing method for teaching implementation. Through classroom observation records and post-class concept map scoring, the effectiveness of the situational teaching method in enhancing students’ ability to transfer knowledge in context and apply it is verified. The results show that students in the experimental group are significantly better than those in the traditional teaching class in terms of the structural integrity of concept maps and the accuracy of clinical case analysis (p < 0.05), indicating that the situational teaching method can effectively promote deep understanding of medicinal chemistry knowledge and clinical application ability.