双网络水凝胶在骨组织再生中的应用及研究进展
Application and Research Progress of Double Network Hydrogels in Bone Regeneration
DOI: 10.12677/acm.2025.1592528, PDF,   
作者: 李林洁, 付 钢*：重庆医科大学附属口腔医院修复科，重庆；口腔疾病研究重庆市重点实验室，重庆
关键词: 双网络水凝胶；力学性能；骨组织再生；药物递送；智能响应；Double Network Hydrogels； Mechanical Properties； Bone Regeneration； Drug Delivery； Intelligent Response
摘要: 双网络水凝胶是由刚性的第一网络和柔韧的第二网络协同构成的高分子聚合物。与传统单网络水凝胶相比，其机械强度有了大幅提升的同时，仍保持较好的生物相容性和刺激响应性，在组织工程与再生医学领域展现出广阔应用前景。本文综述了目前双网络水凝胶的构筑方法，总结了其在递送生物活性物质、构建力学适配微环境及智能响应修复三方面的应用进展。
Abstract: Double network hydrogels are composed of a rigid first network and a flexible second network. Compared with traditional single network hydrogels, their mechanical strength has been substantially improved while still maintaining better biocompatibility and stimulus responsiveness, showing broad application prospects in the field of tissue engineering and regenerative medicine. In this review, we conclude the current construction methods of double network hydrogels and summarize the progress of their application in bone defect repair as delivery of bioactive substances, construction of mechanically compatible microenvironments, and intelligent response repair.
文章引用：李林洁, 付钢. 双网络水凝胶在骨组织再生中的应用及研究进展[J]. 临床医学进展, 2025, 15(9): 572-579. https://doi.org/10.12677/acm.2025.1592528

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