百合固金汤加减治疗肺癌及相关性并发症的研究进展

Research Progress on the Modified Lily Consolidating Metal Decoction in the Treatment of Lung Cancer and Related Complications

摘要: 肺癌是全球发病率较高的恶性肿瘤之一，现代医学主要运用手术切除、放化疗、生物靶向治疗等手段治疗，虽能一定程度地治疗肺癌的发生、发展，减轻患者临床症状，但也会出现血液系统毒性、胃肠道反应等毒副作用。百合固金汤出于《慎斋遗书》，具有养阴润肺、化痰止咳之功效，是治疗肺肾阴虚、虚火上炎的经典方剂，现代医家扩展应用于肺癌及并发症治疗中，具有良好疗效。研究发现，百合固金汤通过调节免疫细胞、降低炎症细胞、调控相关通路等机制干预肺癌的发生、发展；临床应用可以减轻临床症状，提高生活质量、降低肿瘤指标，增强免疫功能、配合西医治疗，减轻毒副作用；同时还能改善肺癌相关性咳嗽、咯血、胸腔积液等并发症，疗效良好，且价格低廉、安全无毒，适合肺癌患者长期服用，可在临床推广。通过整理近年来百合固金汤加减治疗肺癌及相关性并发症的干预作用的临床及实验研究相关文献，以期为本方后续深入研究和肿瘤治疗新模式开展提供有益参考和借鉴。

Abstract: Lung cancer is one of the malignant tumors with a relatively high incidence rate worldwide. Modern medicine mainly employs surgical resection, radiotherapy and chemotherapy, and biological targeted therapy to treat it. Although these methods can to some extent control the occurrence and development of lung cancer, alleviate the clinical symptoms of patients, they may also cause adverse reactions such as hematological toxicity and gastrointestinal reactions. The Lily and Baihe Gujin Decoction, originated from “Shenzhai Yishu”, has the functions of nourishing yin and moistening the lung, and resolving phlegm and relieving cough. It is a classic prescription for treating lung and kidney yin deficiency and upward inflammation of false fire. Modern medical practitioners have expanded its application in the treatment of lung cancer and its complications, achieving good therapeutic effects. Studies have found that the Lily and Baihe Gujin Decoction can intervene in the occurrence and development of lung cancer by regulating immune cells, reducing inflammatory cells, and regulating related pathways. In clinical application, it can alleviate clinical symptoms, improve the quality of life, lower tumor markers, enhance immune function, cooperate with Western medicine treatment, and reduce adverse reactions. At the same time, it can also improve complications related to lung cancer such as cough, hemoptysis, and pleural effusion, with good therapeutic effects. Moreover, it is inexpensive, safe and non-toxic, suitable for long-term use by lung cancer patients, and can be promoted in clinical practice. By collating the relevant literature on the intervention effects of modified Lily and Baihe Gujin Decoction in the treatment of lung cancer and related complications in recent years, it is hoped to provide useful references and inspirations for the in-depth research of this prescription and the development of new tumor treatment models.