非稳态负荷与认知功能障碍关联性的研究进展
Research Progress on the Association between Allostatic Load and Cognitive Dysfunction
DOI: 10.12677/acm.2025.1592586, PDF,    科研立项经费支持
作者: 姜珊珊, 杨佳妮：安徽医科大学护理学院，安徽 合肥；李玉红*：安徽医科大学护理学院，安徽 合肥；安徽医科大学泰康康养产业研究院，安徽 合肥
关键词: 非稳态负荷；认知功能障碍；慢性应激；Allostatic Load； Cognitive Dysfunction； Chronic Stress
摘要: 认知功能障碍作为全球公共健康问题，严重影响患者生理、心理和社会健康。随着世界人口老龄化的加速，认知功能障碍人群比重不断增加，逐渐向年轻化发展，日益成为医疗保健系统、社会和家庭的重大负担。早期识别和干预认知功能障碍具有重要意义。研究发现，慢性应激在认知功能障碍发生发展中起重要作用。非稳态负荷作为衡量慢性应激的客观指标，其与认知功能障碍之间的关联成为近年研究的热点。本文通过系统、全面探讨非稳态负荷及其组成部分与认知功能障碍的关系，总结其潜在机制，为降低认知功能障碍的发生风险提供新的预防及干预思路。
Abstract: Cognitive dysfunction, as a global public health issue, seriously affects the physical, psychological and social health of patients. With the acceleration of the aging of the world’s population, the proportion of people with cognitive dysfunction is constantly increasing, gradually trending younger, and increasingly becoming a major burden on the healthcare system, society and families. Early identification and intervention of cognitive dysfunction is of great significance. Studies have found that chronic stress plays an important role in the occurrence and development of cognitive dysfunction. As an objective indicator for measuring chronic stress, the association between allostatic Load and cognitive dysfunction has become a research hotspot in recent years. In this paper, we summarize the potential mechanisms by systematically and comprehensively exploring the relationship between allostatic load and its components and cognitive dysfunction. The results of this study provide new ideas for prevention and intervention to reduce the risk of developing cognitive dysfunction.
文章引用：姜珊珊, 杨佳妮, 李玉红. 非稳态负荷与认知功能障碍关联性的研究进展[J]. 临床医学进展, 2025, 15(9): 1005-1015. https://doi.org/10.12677/acm.2025.1592586

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