肺康复在慢性阻塞性肺疾病中的研究进展
Research Progress of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease
DOI: 10.12677/acm.2025.1592587, PDF,   
作者: 王 菲, 王 婷:西安医学院临床医学院,陕西 西安;温红侠*:陕西省人民医院呼吸与危重症内二科,陕西 西安
关键词: 慢性阻塞性肺疾病肺康复运动训练无创通气技术Chronic Obstructive Pulmonary Disease Pulmonary Rehabilitation Sports Training Noninvasive Ventilation
摘要: 慢性阻塞性肺疾病是一种肺部的异质性疾病,而肺康复是目前慢阻肺非药物治疗中疗效较为显著的一种方法,旨在对病人进行全面评估后,进行个体化的运动、呼吸训练、营养干预等,为减轻患者的症状并且提高患者生存质量的一项综合治疗方案。自从1974年美国提出“肺康复”一词后,肺康复的概念、形式及内容逐渐发生改变,从仅依靠药物治疗补充到呼吸锻炼,运动训练及中医技术,其已经成为临床医生应用于慢阻肺患者的共识并在指南上已经有所体现。但最佳肺康复方式以及个体化治疗尚无定论且疗效不稳定,也是众多学者现在研究的问题。该文通过检索国内外相关文献来综述慢性阻塞性肺疾病肺康复的研究进展。
Abstract: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease of the lung. Pulmonary rehabilitation is an effective method in non-drug treatment of COPD at present. It aims to conduct individualized exercise training, respiratory training and nutritional intervention after a comprehensive assessment of the patient, so as to reduce the symptoms of the patient and improve the quality of life of the patient. After the term “pulmonary rehabilitation” was proposed in the United States in 1974, the concept, form and content of pulmonary rehabilitation gradually changed, from only as a supplement to drug therapy to breathing exercise, sports training and traditional Chinese medicine techniques, which has become the consensus of clinicians to apply to COPD patients and has been reflected in the guidelines. However, the efficacy of early pulmonary rehabilitation in patients with acute exacerbation is still uncertain and has been studied by many scholars. This article reviews the progress of pulmonary rehabilitation in the early stage of chronic obstructive pulmonary disease by searching relevant literature at home and abroad.
文章引用:王菲, 王婷, 温红侠. 肺康复在慢性阻塞性肺疾病中的研究进展[J]. 临床医学进展, 2025, 15(9): 1016-1024. https://doi.org/10.12677/acm.2025.1592587

参考文献

[1] 陈典, 隆寰宇, 李姝润, 等. 2024年GOLD慢性阻塞性肺疾病诊断、治疗、管理及预防全球策略更新要点解读[J]. 中国全科医学, 2024, 27(13): 1533-1543+1567.
[2] Rochester, C.L., Alison, J.A., Carlin, B., Jenkins, A.R., Cox, N.S., Bauldoff, G., et al. (2023) Pulmonary Rehabilitation for Adults with Chronic Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline. American Journal of Respiratory and Critical Care Medicine, 208, e7-e26. [Google Scholar] [CrossRef] [PubMed]
[3] Naghavi, M., Abajobir, A.A., Abbafati, C., et al. (2017) Global, Regional, And national Age-Sex Specific Mortality for 264 Causes of Death, 1980-2016: A Systematic Analysis for the Global Burden of Disease Study 2016. The Lancet, 390, 1151-1210.
[4] 查震球. 慢性阻塞性肺疾病流行病学研究进展[J]. 安徽预防医学杂志, 2022, 28(3): 171-176.
[5] 张长洪, 刘建华, 赵建清, 等. 老年人群慢性阻塞性肺疾病流行病学及其影响因素[J]. 中国老年学杂志, 2023, 43(19): 4851-4854.
[6] Xu, J., Zeng, Q., Li, S., Su, Q. and Fan, H. (2024) Inflammation Mechanism and Research Progress of COPD. Frontiers in Immunology, 15, Article ID: 1404615. [Google Scholar] [CrossRef] [PubMed]
[7] McKeough, Z.J., Velloso, M., Lima, V.P. and Alison, J.A. (2016) Upper Limb Exercise Training for COPD. Cochrane Database of Systematic Reviews, No. 11, CD011434. [Google Scholar] [CrossRef] [PubMed]
[8] 盛梅梅, 罗专波. 慢性阻塞性肺疾病发病机制的研究现状及进展[J]. 现代医学与健康研究电子杂志, 2023, 7(1): 38-41.
[9] 王瑞萍, 虞涛, 张妮. 肺康复对老年COPD患者疗效及CPET对肺康复的评估价值[J]. 中国老年学杂志, 2024, 44(13): 3108-3112.
[10] 林冠旭, 李翠. 血清炎症因子水平与慢性阻塞性肺疾病严重程度的相关性[J]. 医学综述, 2019, 25(18): 3720-3723+3727.
[11] da Silva e Silva, C.M., Gomes Neto, M., Saquetto, M.B., da Conceição, C.S. and Souza-Machado, A. (2018) Effects of Upper Limb Resistance Exercise on Aerobic Capacity, Muscle Strength, and Quality of Life in COPD Patients: A Randomized Controlled Trial. Clinical Rehabilitation, 32, 1636-1644. [Google Scholar] [CrossRef] [PubMed]
[12] Spruit, M.A., Singh, S.J., Garvey, C., et al. (2013) An Official American Thoracic Society/European Respiratory Society Statement: Key Concepts and Advances in Pulmonary Rehabilitation. American Journal of Respiratory and Critical Care Medicine, 188, e13-e64.
[13] 中国医师学会呼吸医师分会, 中华医学会呼吸分会, 等. 中国慢性呼吸道疾病呼吸康复管理指南(2021年) [J]. 中国健康管理杂志, 2021, 15(6): 521-538
[14] (2025) Global Strategy for Prevention, Diagnosis and Management Of COPD: 2025 Report.
https://goldcopd.org/2025-gold-report/
[15] Meneses-Echavez, J.F., Chavez Guapo, N., Loaiza-Betancur, A.F., Machado, A. and Bidonde, J. (2023) Pulmonary Rehabilitation for Acute Exacerbations of COPD: A Systematic Review. Respiratory Medicine, 219, Article 107425. [Google Scholar] [CrossRef] [PubMed]
[16] 董校玉, 赵倩. 阈值压力负荷呼吸肌训练对慢性阻塞性肺疾病患者肺功能、运动耐力及呼吸肌肌力的影响[J]. 保健医学研究与实践, 2022, 19(7): 101-104.
[17] Cai, Y., Ren, X., Wang, J., Ma, B. and Chen, O. (2024) Effects of Breathing Exercises in Patients with Chronic Obstructive Pulmonary Disease: A Network Meta-Analysis. Archives of Physical Medicine and Rehabilitation, 105, 558-570. [Google Scholar] [CrossRef] [PubMed]
[18] 余雪莹, 曾丹, 李三, 等. 吸气肌训练在呼吸系统疾病康复中的研究进展[J]. 临床肺科杂志, 2024, 29(1): 94-99.
[19] Tounsi, B., Acheche, A., Lelard, T., Tabka, Z., Trabelsi, Y. and Ahmaidi, S. (2021) Effects of Specific Inspiratory Muscle Training Combined with Whole-Body Endurance Training Program on Balance in COPD Patients: Randomized Controlled Trial. PLOS ONE, 16, e0257595. [Google Scholar] [CrossRef] [PubMed]
[20] Ichiba, T., Miyagawa, T., Tsuda, T., Kera, T. and Yasuda, O. (2023) Changes in Diaphragm Thickness and 6-Min Walking Distance Improvement after Inspiratory Muscle Training in Patients with Chronic Obstructive Pulmonary Disease: Clinical Trial. Heliyon, 9, e20079. [Google Scholar] [CrossRef] [PubMed]
[21] Belli, S., Prince, I., Savio, G., Paracchini, E., Cattaneo, D., Bianchi, M., et al. (2021) Airway Clearance Techniques: The Right Choice for the Right Patient. Frontiers in Medicine, 8, Article ID: 544826. [Google Scholar] [CrossRef] [PubMed]
[22] de Alvarenga, G.M., Remigio Gamba, H., Elisa Hellman, L., Ganzert Ferrari, V. and Michel de Macedo, R. (2016) Physiotherapy Intervention during Level I of Pulmonary Rehabilitation on Chronic Obstructive Pulmonary Disease: A Systematic Review. The Open Respiratory Medicine Journal, 10, 12-19. [Google Scholar] [CrossRef] [PubMed]
[23] Nicolini, A., Grecchi, B., Ferrari-Bravo, M. and Barlascini, C. (2018) Safety and Effectiveness of the High-Frequency Chest Wall Oscillation vs Intrapulmonary Percussive Ventilation in Patients with Severe COPD. International Journal of Chronic Obstructive Pulmonary Disease, 13, 617-625. [Google Scholar] [CrossRef] [PubMed]
[24] 中华医学会, 中华医学会杂志社, 等. 中国慢性阻塞性肺疾病基层诊疗与管理指南(2024年) [J]. 中华全科医师杂志, 2024, 23(6): 578-602.
[25] Nolan, C.M. and Rochester, C.L. (2019) Exercise Training Modalities for People with Chronic Obstructive Pulmonary Disease. COPD: Journal of Chronic Obstructive Pulmonary Disease, 16, 378-389. [Google Scholar] [CrossRef] [PubMed]
[26] Karagiannis, C., Savva, C., Korakakis, V., Adamide, T., Georgiou, A., Matheou, I., et al. (2021) Effect of Strength versus Strength and Endurance Upper Limb Exercise Training in Patients with Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial. Journal of Cardiopulmonary Rehabilitation and Prevention, 41, 426-431. [Google Scholar] [CrossRef] [PubMed]
[27] Jenkins, A.R., Burtin, C., Camp, P.G., Lindenauer, P., Carlin, B., Alison, J.A., et al. (2024) Do Pulmonary Rehabilitation Programmes Improve Outcomes in Patients with COPD Posthospital Discharge for Exacerbation: A Systematic Review and Meta-analysis. Thorax, 79, 438-447. [Google Scholar] [CrossRef] [PubMed]
[28] Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., et al. (2023) Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting. International Journal of Molecular Sciences, 24, Article 6454. [Google Scholar] [CrossRef] [PubMed]
[29] Memme, J.M., Erlich, A.T., Phukan, G. and Hood, D.A. (2021) Exercise and Mitochondrial Health. The Journal of Physiology, 599, 803-817. [Google Scholar] [CrossRef] [PubMed]
[30] Zhao, Y. and Gao, B. (2024) Integrative Effects of Resistance Training and Endurance Training on Mitochondrial Remodeling in Skeletal Muscle. European Journal of Applied Physiology, 124, 2851-2865. [Google Scholar] [CrossRef] [PubMed]
[31] Chen, X., Xu, L., Li, S., Yang, C., Wu, X., Feng, M., et al. (2024) Efficacy of Respiratory Support Therapies during Pulmonary Rehabilitation Exercise Training in Chronic Obstructive Pulmonary Disease Patients: A Systematic Review and Network Meta-analysis. BMC Medicine, 22, Article No. 389. [Google Scholar] [CrossRef] [PubMed]
[32] Xiao, J., Wu, Y., Wang, L. and Zhou, H. (2025) Effect of Precise Pulmonary Rehabilitation Nursing Intervention Combined with Simultaneous Inhalation Therapy and Noninvasive Ventilation for Chronic Obstructive Pulmonary Disease Patients with Chronic Hypercapnic Respiratory Failure. The Clinical Respiratory Journal, 19, e70049. [Google Scholar] [CrossRef] [PubMed]
[33] Chen, Y., Zhang, P., Dong, Z., Zhu, Y., Liu, Y., Qiao, C., et al. (2024) Effect of Baduanjin Exercise on Health and Functional Status in Patients with Chronic Obstructive Pulmonary Disease: A Community-Based, Cluster-Randomized Controlled Trial. npj Primary Care Respiratory Medicine, 34, Article No. 43. [Google Scholar] [CrossRef] [PubMed]
[34] Phantayuth, D., Chuaychoo, B., Supaporn, S., Nana, A., Ramyarangsi, P. and Ajjimaporn, A. (2024) Effectiveness of a 12-Week Combining Tai Chi and Yoga Program on Pulmonary Function and Functional Fitness in COPD Patients. Respiratory Medicine, 234, Article 107842. [Google Scholar] [CrossRef] [PubMed]
[35] Keogh, E. and Mark Williams, E. (2021) Managing Malnutrition in COPD: A Review. Respiratory Medicine, 176, Article 106248. [Google Scholar] [CrossRef] [PubMed]
[36] Oyama, Y., Tatsumi, H., Takikawa, H., Taniguchi, N. and Masuda, Y. (2024) Combined Effect of Early Nutrition Therapy and Rehabilitation for Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Prospective Randomized Controlled Trial. Nutrients, 16, Article 739. [Google Scholar] [CrossRef] [PubMed]
[37] Wouters, E.F., Posthuma, R., Koopman, M., Liu, W., Sillen, M.J., Hajian, B., et al. (2020) An Update on Pulmonary Rehabilitation Techniques for Patients with Chronic Obstructive Pulmonary Disease. Expert Review of Respiratory Medicine, 14, 149-161. [Google Scholar] [CrossRef] [PubMed]
[38] Jin, S., Huang, B., Kong, Y., Zhou, X. and Ma, J. (2025) Effect of Neuromuscular Electrical Stimulation Combined with Respiratory Rehabilitation Training on Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease. Journal of Cardiothoracic Surgery, 20, Article No. 79. [Google Scholar] [CrossRef] [PubMed]
[39] Sillen, M.J.H., Franssen, F.M.E., Delbressine, J.M.L., Vaes, A.W., Wouters, E.F.M. and Spruit, M.A. (2014) Efficacy of Lower-Limb Muscle Training Modalities in Severely Dyspnoeic Individuals with COPD and Quadriceps Muscle Weakness: Results from the DICES Trial. Thorax, 69, 525-531. [Google Scholar] [CrossRef] [PubMed]
[40] Priego-Jiménez, S., Cavero-Redondo, I., Pascual-Morena, C., Martínez-García, I., Martínez-Vizcaíno, V. and Álvarez-Bueno, C. (2024) Effect of Different Exercise Programs on Lung Function in People with Chronic Obstructive Pulmonary Disease: A Network Meta-Analysis of RCTS. Annals of Physical and Rehabilitation Medicine, 67, Article 101792. [Google Scholar] [CrossRef] [PubMed]
[41] Zanaboni, P., Dinesen, B., Hoaas, H., Wootton, R., Burge, A.T., Philp, R., et al. (2023) Long-Term Telerehabilitation or Unsupervised Training at Home for Patients with Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial. American Journal of Respiratory and Critical Care Medicine, 207, 865-875. [Google Scholar] [CrossRef] [PubMed]
[42] Cox, N.S. and Khor, Y.H. (2023) Telerehabilitation in Pulmonary Diseases. Current Opinion in Pulmonary Medicine, 29, 313-321. [Google Scholar] [CrossRef] [PubMed]
[43] Ataç, A., Pehlivan, E., Karaahmetoğlu, F.S., Özcan, Z.B., Çınarka, H., Çörtük, M., et al. (2024) The Impact of Different Telerehabilitation Methods on Peripheral Muscle Strength and Aerobic Capacity in COPD Patients: A Randomized Controlled Trial. Advances in Respiratory Medicine, 92, 370-383. [Google Scholar] [CrossRef] [PubMed]
[44] Cox, N.S., McDonald, C.F., Mahal, A., Alison, J.A., Wootton, R., Hill, C.J., et al. (2022) Telerehabilitation for Chronic Respiratory Disease: A Randomised Controlled Equivalence Trial. Thorax, 77, 643-651. [Google Scholar] [CrossRef] [PubMed]
[45] Zeng, Y., Wu, Q., Chen, Y. and Cai, S. (2024) Early Comprehensive Pulmonary Rehabilitation for Hospitalized Patients with Acute Ex-Acerbation of Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial. Journal of Rehabilitation Medicine, 56, jrm39953. [Google Scholar] [CrossRef] [PubMed]
[46] Lu, H.Y., Chen, C., Lee, D.L., Tsai, Y. and Lin, P. (2023) Effects of Early Pulmonary Rehabilitation on Hospitalized Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. International Journal of Chronic Obstructive Pulmonary Disease, 18, 881-893. [Google Scholar] [CrossRef] [PubMed]
[47] Bishop, J.A., Spencer, L.M., Dwyer, T.J., McKeough, Z.J., McAnulty, A., Leung, R., et al. (2025) Effect of Pulmonary Rehabilitation Duration on Exercise Capacity and Health-Related Quality of Life in People with chronic Obstructive Pulmonary Disease (Pure Duration Trial): A Randomized Controlled Equivalence Trial. Respirology, 30, 41-50. [Google Scholar] [CrossRef] [PubMed]
[48] Blervaque, L., Préfaut, C., Forthin, H., Maffre, F., Bourrelier, M., Héraud, N., et al. (2021) Efficacy of a Long-Term Pulmonary Rehabilitation Maintenance Program for COPD Patients in a Real-Life Setting: A 5-Year Cohort Study. Respiratory Research, 22, Article No. 79. [Google Scholar] [CrossRef] [PubMed]
[49] Alexiou, C., Ward, L., Hume, E., Armstrong, M., Wilkinson, M. and Vogiatzis, I. (2021) Effect of Interval Compared to Continuous Exercise Training on Physiological Responses in Patients with Chronic Respiratory Diseases: A Systematic Review and Meta-Analysis. Chronic Respiratory Disease, 18, 1-15. [Google Scholar] [CrossRef] [PubMed]