鼠李糖乳杆菌和罗伊氏乳杆菌复合含片联合牙周基础治疗改善牙周炎的效果
Effect of Lactobacillus rhamnosus and Lactobacillus reuteri Lozenge Combined with Basic Periodontal Therapy in Improving Periodontitis
摘要: 目的：研究和评价鼠李糖乳杆菌和罗伊氏乳杆菌复合含片(即益生菌含片)结合牙周基础治疗对牙周炎患者的治疗效果。方法：将牙周炎患者50例平均分成两组，一组为实验组(采用牙周基础治疗 + 益生菌含片)，另一组为对照组(采用牙周基础治疗 + 安慰剂)，对比治疗前及治疗4周后牙周指标(PD､CAL､SBI和PLI)及龈下菌斑中致病菌(牙龈卟啉单胞菌、福赛坦氏菌和齿垢密螺旋体)的丰度变化。结果：经益生菌含片治疗后，实验组患者牙周指标PD､CAL､SBI和PLI较对照组明显改善(P < 0.05)，且龈下菌斑中牙龈卟啉单胞菌、福赛坦氏菌和齿垢密螺旋体的相对丰度也显著降低(P < 0.01)。结论：鼠李糖乳杆菌和罗伊氏乳杆菌复合含片可增强牙周基础治疗效果，对龈下菌斑里致病菌的生长有抑制作用。
Abstract: Objective: The aim is to assess the clinical effectiveness of a lozenge with Lactobacillus rhamnosus and Lactobacillus reuteri in combination (probiotic lozenge) as an addition to basic periodontal treatment for patients with chronic periodontitis. Methods: Fifty patients with chronic periodontitis were randomly split into two groups in equal numbers: the experimental group (receiving basic periodontal treatment plus probiotic lozenges) and the control group (receiving basic periodontal treatment plus a placebo). A comparison was made of the periodontal parameters (including PD, CAL, SBI, and PLI) and the relative abundance of certain periodontal pathogens (such as Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) in subgingival plaque at baseline and 4 weeks post-treatment. Results: After treatment with probiotic lozenges, the experimental group showed significant improvements in periodontal parameters including PD, CAL, SBI, and PLI compared to the control group (P < 0.05). Additionally, the relative abundance of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola in subgingival plaque was significantly reduced (P < 0.01). Conclusion: The compound lozenges containing Lactobacillus rhamnosus and Lactobacillus reuteri can enhance the efficacy of basic periodontal therapy and inhibit the growth of pathogenic bacteria in subgingival plaque.
文章引用：仇晨光, 佘鹏, 孙洪涛, 王静娟. 鼠李糖乳杆菌和罗伊氏乳杆菌复合含片联合牙周基础治疗改善牙周炎的效果[J]. 临床个性化医学, 2025, 4(5): 30-35. https://doi.org/10.12677/jcpm.2025.45456

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