瑞马唑仑在全麻诱导中的应用：不同年龄段人群的研究进展
The Application of Remimazolam in General Anesthesia Induction: Research Progress in Different Age Groups
DOI: 10.12677/acm.2025.1592615, PDF,   
作者: 周芙蓉, 朱沛宇：延安大学医学院，陕西 延安；李玲霞：延安大学附属医院麻醉与围术期医学科，陕西 延安
关键词: 瑞马唑仑；全麻诱导；年龄；药代动力学；药效学；Remazolam； Induction of General Anesthesia； Age； Pharmacokinetics； Pharmacodynamics
摘要: 瑞马唑仑作为一种新型的超短效镇静药物，具有起效快、恢复快、无蓄积且对肝肾功能和血流动力学影响小等特性，近年来在全身麻醉领域展现出独特的优势。现有研究表明，瑞马唑仑的药代动力学和药效学特征在不同年龄群体中可能存在差异，且这种差异可能会对患者的镇静深度和临床效果造成直接影响。现就瑞马唑仑用于不同年龄段(儿童、成人及老年)全麻患者诱导时镇静效果及安全性的临床证据和研究进展作一综述，以期为临床麻醉应用提供参考。
Abstract: As a new type of ultra-short-acting sedative drug, remazolam, with fast onset of action, rapid recovery, no accumulation, and little effect on hepatic and renal function and hemodynamics, has demonstrated unique advantages in general anesthesia in recent years. Existing studies have shown that the pharmacokinetic and pharmacodynamic characteristics of remazolam may differ in different age groups, and such differences may have a direct impact on the depth of sedation and clinical outcome of patients. The clinical evidence and research progress on the sedation effect and safety of remazolam for induction of general anesthesia in patients of different age groups (children, adults and the elderly) are reviewed, with a view to providing reference for clinical anesthesia application.
文章引用：周芙蓉, 李玲霞, 朱沛宇. 瑞马唑仑在全麻诱导中的应用：不同年龄段人群的研究进展[J]. 临床医学进展, 2025, 15(9): 1233-1239. https://doi.org/10.12677/acm.2025.1592615

参考文献

[1] 陈荣锋. 全身麻醉诱导研究现状[J]. 医学信息, 2025, 38(6): 186-192.
[2] 赵娟, 陈金权. 瑞马唑仑对老年大鼠海马B淋巴细胞瘤-2、一氧化氮合酶蛋白表达及神经元凋亡和认知功能的影响[J]. 陕西医学杂志, 2022, 51(3): 289-292.
[3] Colin, P.J., Bichajian, L.H., Curt, V.R., Koomen, J.V., Stöhr, T., Struys, M.M.R.F., et al. (2025) Pharmacokinetics and Pharmacodynamics of Remimazolam for Procedural Sedation in Children and Adolescents. Anesthesiology, 143, 368-382. [Google Scholar] [CrossRef] [PubMed]
[4] 陈倩倩, 潘志浩, 顾俐妮. 瑞马唑仑在老年患者全麻诱导中的应用研究[J]. 浙江医学, 2025, 47(4): 414-417.
[5] Xing, Y., Lang, Z., Wang, X., Liu, J., Han, X., Zhou, J., et al. (2025) Anesthetic Efficacy with Remimazolam Compared with Propofol: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. International Journal of Surgery. [Google Scholar] [CrossRef] [PubMed]
[6] Eleveld, D.J., Colin, P.J., Van den Berg, J.P., Koomen, J.V., Stoehr, T. and Struys, M.M.R.F. (2025) Development and Analysis of a Remimazolam Pharmacokinetics and Pharmacodynamics Model with Proposed Dosing and Concentrations for Anaesthesia and Sedation. British Journal of Anaesthesia, 135, 206-217. [Google Scholar] [CrossRef] [PubMed]
[7] Cai, Y., Dong, L., Zhong, J.W., Lin, Z., Chen, C., Zhu, L., et al. (2025) ED50 and ED95 of Remimazolam for Loss of Consciousness in Young Children: A Dose-Finding Study for Induction of Anaesthesia. British Journal of Anaesthesia, 134, 1709-1716. [Google Scholar] [CrossRef] [PubMed]
[8] Chen, Y., Zhang, W., Ma, J., Liu, W., Song, X. and Chen, X. (2025) The Influence of Age on the Effective Dosage of Intravenous Remimazolam for the Relief of Preoperative Anxiety in Pediatric Patients at Median and 95% Effective Doses: A Prospective Study. Drug Design, Development and Therapy, 19, 4605-4615. [Google Scholar] [CrossRef] [PubMed]
[9] Fang, Y., Zhong, J.W., Szmuk, P., Lyu, Y., Xu, Y., Qu, S., et al. (2024) Safety and Efficacy of Remimazolam Tosilate for General Anaesthesia in Paediatric Patients Undergoing Elective Surgery: A Multicentre, Randomised, Single‐Blind, Controlled Trial. Anaesthesia, 80, 259-268. [Google Scholar] [CrossRef] [PubMed]
[10] Choe, J.W., Chung, M.J., Park, S.W., Oh, D., Han, S.Y., Yang, M.J., et al. (2024) Safety and Efficacy of Remimazolam versus Propofol during EUS: A Multicenter Randomized Controlled Study. Gastrointestinal Endoscopy, 100, 183-191.e1. [Google Scholar] [CrossRef] [PubMed]
[11] Hansen, T.G. and Engelhardt, T. (2025) The Promise of Precision: Exploring the Role of Remimazolam in Paediatric Anaesthesia. British Journal of Anaesthesia, 134, 1613-1615. [Google Scholar] [CrossRef] [PubMed]
[12] Yang, C., Jiao, J., Nie, Y., Shao, W., Zhang, H. and Huang, S. (2024) Comparison of the Bispectral Indices of Patients Receiving Remimazolam and Propofol for General Anesthesia: A Randomized Crossover Trial. Anaesthesia Critical Care & Pain Medicine, 43, Article ID: 101377. [Google Scholar] [CrossRef] [PubMed]
[13] Kim, H., Min, B., Lee, U., Sim, J., Noh, G., Lee, E., et al. (2024) Electroencephalographic Features of Elderly Patients during Anesthesia Induction with Remimazolam: A Substudy of a Randomized Controlled Trial. Anesthesiology, 141, 681-692. [Google Scholar] [CrossRef] [PubMed]
[14] Lin, Y., Chen, Q., Liao, Y., Xu, B., Zhang, C., Luo, J., et al. (2025) Alfentanil Enhanced the Sedation of Remimazolam during Anaesthesia Induction in Patients Undergoing Urological Day Surgery: A Randomised Controlled Trial. Drug Design, Development and Therapy, 19, 5653-5662. [Google Scholar] [CrossRef] [PubMed]
[15] Takaki, R., Yokose, M., Mihara, T., Saigusa, Y., Tanaka, H., Yamamoto, N., et al. (2024) Hypotension after General Anaesthesia Induction Using Remimazolam or Propofol in Geriatric Patients Undergoing Sevoflurane Anaesthesia with Remifentanil: A Single-Centre, Double-Blind, Randomised Controlled Trial. British Journal of Anaesthesia, 133, 24-32. [Google Scholar] [CrossRef] [PubMed]
[16] 陶晓玉, 官双双, 代晨旭, 等. 甲苯磺酸瑞马唑仑与依托咪酯麻醉诱导对老年衰弱患者血流动力学影响的比较[J/OL]. 解放军医学杂志, 2025:1-11.
https://link.cnki.net/urlid/11.1056.R.20250106.1015.002, 2025-01-06.
[17] Liu, Z., Zhang, X., Wang, X., Liu, Z. and Pang, Y. (2025) Dose-dependent Effects of Remimazolam on Early Perioperative Neurocognitive Disorders in Elderly Colorectal Cancer Patients Undergoing Laparoscopic Surgery. Drug Design, Development and Therapy, 19, 5507-5516. [Google Scholar] [CrossRef] [PubMed]
[18] Hung, K., Wang, W., Liu, W., Hsu, C., Huang, Y., Wu, J., et al. (2024) Comparing Subjective Quality of Recovery between Remimazolam-and Propofol-Based Total Intravenous Anesthesia for Surgical Procedures: A Meta-Analysis. Systematic Reviews, 13, Article No. 235. [Google Scholar] [CrossRef] [PubMed]
[19] Sim, J., Kim, K.M., Lee, U., Lee, E., Noh, G. and Choi, B. (2025) Incidence of Postoperative Delirium and Quality of Recovery in Older Patients Undergoing Gastrectomy under General Anaesthesia with Remimazolam vs. Propofol: A Randomised Non‐Inferiority Study. Anaesthesia. [Google Scholar] [CrossRef] [PubMed]
[20] Wang, D., Liu, Z., Zhang, W., Li, S., Chen, Y., Jiang, C., et al. (2025) Comparison of Remimazolam versus Dexmedetomidine on Hemodynamics in Older Patients under Lower Extremity Orthopedic Surgery with Spinal Anesthesia: A Randomized Controlled Trial. Drug Design, Development and Therapy, 19, 6037-6046. [Google Scholar] [CrossRef] [PubMed]

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