女性高同型半胱氨酸对辅助生殖技术妊娠结局的影响研究进展
Research Progress on the Effect of High Homocysteine in Women on Pregnancy Outcomes of Assisted Reproductive Technology
DOI: 10.12677/jcpm.2025.45461, PDF,   
作者: 朱永萃*, 侯方玉：济宁医学院临床医学院(附属医院)，山东 济宁；杨爱军#：济宁医学院附属医院生殖医学中心，山东 济宁
关键词: 同型半胱氨酸；辅助生殖技术；妊娠结局；高同型半胱氨酸血症；Homocysteine； Assisted Reproductive Technology； Pregnancy Outcome； Hyperhomocysteinemia
摘要: 随着辅助生殖技术(Assisted reproductive technology, ART)的进步，越来越多研究者们的关注点已从评估妊娠成功率转向优化妊娠结局。同型半胱氨酸(homocysteine, Hcy)代谢紊乱可引发一系列女性生育障碍。本文总结Hcy与ART妊娠结局之间的关联，回顾高同型半胱氨酸血症(hyperhomocysteinemia, HHcy)对卵母细胞质量、胚胎发育、子宫内膜容受性以及胎盘作用的潜在有害机制。HHcy与ART妊娠丢失、流产和子痫前期等不良妊娠结局密切相关，全面总结了针对Hcy水平异常所采取的补救措施，包括但不限于营养素补充、生活方式改变等，最终为改善ART妊娠结局提供理论框架和支持。
Abstract: With the advancement of assisted reproductive technology (ART), more and more researchers have shifted their focus from evaluating pregnancy success rates to optimizing pregnancy outcomes. Disorders in homocysteine (Hcy) metabolism can cause a series of female fertility disorders. This article summarizes the association between Hcy and ART pregnancy outcomes, and reviews the potential harmful mechanisms of hyperhomocysteinemia (HHcy) on oocyte quality, embryonic development, endometrial receptivity, and placental effects. HHcy is closely related to adverse pregnancy outcomes such as ART pregnancy loss, miscarriage, and preeclampsia. This article comprehensively summarizes the remedial measures taken for abnormal Hcy levels, including but not limited to nutrient supplementation and lifestyle changes, ultimately providing a theoretical framework and support for improving ART pregnancy outcomes.
文章引用：朱永萃, 杨爱军, 侯方玉. 女性高同型半胱氨酸对辅助生殖技术妊娠结局的影响研究进展[J]. 临床个性化医学, 2025, 4(5): 67-73. https://doi.org/10.12677/jcpm.2025.45461

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