右美托咪定改善围术期睡眠障碍的研究进展
Research Progress on Dexmedetomidine in Improving Perioperative Sleep Disorders
DOI: 10.12677/acm.2025.1592618, PDF,   
作者: 叶 丽：吉首大学医学院，湖南 吉首；何 群*：吉首大学第一附属医院麻醉科，湖南 吉首
关键词: 右美托咪定；睡眠障碍；围手术期；昼夜节律；Dexmedetomidine； Sleep Disorders； Perioperative Period； Circadian Rhythm
摘要: 睡眠是人的基本生理需求之一，对于维系身心健康发挥着重要的作用。良好的睡眠对人的日常工作及生活必不可少，其在维系大脑功能、免疫功能、心理健康、新陈代谢、注意力及学习能力方面有着积极作用。围术期睡眠障碍可以表现为睡眠总时间的减少、睡眠质量的下降及昼夜节律的紊乱等，对疾病的预后产生消极影响，迫切需要找到更加优化的防治措施。右美托咪定是一种高选择性的α2-肾上腺素能受体激动剂，其在镇静、镇痛、抗交感方面的作用已被广泛熟知。近年来，其对睡眠–觉醒周期及昼夜节律的调节作用也被证实，多项研究表明右美托咪定可能改善围术期睡眠质量，其效果与给药方案有关，右美托咪定改善围术期睡眠质量可能与其抗炎镇痛、抗焦虑、抗抑郁及其对昼夜节律的调节有关。
Abstract: Sleep is one of the basic physiological needs of human beings and plays an important role in maintaining physical and mental health. Good sleep is essential for daily work and life, and has positive effects on brain function, immune function, mental health, metabolism, concentration and learning ability. Perioperative sleep disorders can be manifested as reduction of total sleep time, decline of sleep quality and disturbance of circadian rhythm, which have negative effects on the prognosis of the disease. It is urgent to find more optimized prevention and treatment measures. Dexmedetomidine is a highly selective α2-adrenergic receptor agonist, and its sedative, analgesic, and antisympathetic effects are well known. In recent years, its regulation of sleep-wake cycle and circadian rhythm has also been confirmed. Dexmedetomidine improves sleep quality, which may be related to its anti-inflammatory analgesia, anti-anxiety, anti-depression and regulation of circadian rhythm.
文章引用：叶丽, 何群. 右美托咪定改善围术期睡眠障碍的研究进展[J]. 临床医学进展, 2025, 15(9): 1255-1264. https://doi.org/10.12677/acm.2025.1592618

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