糖尿病肾病不同分期与Cys-C、尿微量白蛋白及TRFU的表达水平的相关性分析

Correlation Analysis of Cys-C, UMA and TRFU Expression Levels with Different Stages of Diabetes Nephropathy

摘要: 目的：探讨半胱氨酸蛋白酶抑制因子(Cystatin C, Cys-C)、尿微量白蛋白(Urinary Microalbumin, UMA)及转铁蛋白(Urinary Transferrin, TRFU)表达水平与糖尿病肾病(Diabetic Nephropathy, DN)不同分期的相关性。方法：选取2023年6月~2024年12月期间我院确诊的DN患者60例(观察组)，另选同期单纯糖尿病患者30例(对照组)。检测两组血清Cys-C、尿UMA及尿TRFU水平。结果：观察组血清Cys-C、尿UMA和尿TRFU水平显著高于对照组(1.58 ± 0.42 vs 1.12 ± 0.27 mg/L，46.34 ± 10.87 vs 28.75 ± 6.23 mg/L，7.54 ± 2.31 vs 4.83 ± 2.12 mg/L，均P < 0.001)；DN不同分期患者的血清Cys-C、尿UMA及尿TRFU水平比较差异具有统计学意义(P < 0.05)。血清Cys-C、尿UMA和尿TRFU与DN分期呈显著正相关(r值分别为0.903、0.876、0.892，均P < 0.001)。ROC曲线分析结果显示，三项生物标志物均具有良好的诊断效能(P < 0.05)。结论：DN患者血清Cys-C、尿UMA和尿TRFU水平显著升高，且随疾病分期呈上升趋势，诊断效能较高。

Abstract: Objective: To explore the correlation between the expression levels of Cys-C, UMA and TRFU and the different stages of diabetes nephropathy (DN). Methods: From June 2023 to December 2024, 60 patients with DN diagnosed by our Hospital (observation group) and 30 patients with simple diabetes (control group) were selected to detect the levels of serum Cys-C, urinary UMA, and urinary TRFU in two groups. Result: The levels of serum Cys-C, urinary UMA and urinary trfu in the observation group were significantly higher than those in the control group (1.58 ± 0.42 vs 1.12 ± 0.27 mg/L, 46.34 ± 10.87 vs 28.75 ± 6.23 mg/L, 7.54 ± 2.31 vs 4.83 ± 2.12 mg/L, all P < 0.001). The differences in serum Cys-C, urinary UMA, and urinary TRFU levels among patients with DN at different stages were statistically significant (P < 0.05). Serum Cys-C, urine UMA, and urine TRFU were significantly positively correlated with DN staging (r = 0.903, 0.876, 0.892, all P < 0.001). ROC curve analysis showed that the three biomarkers had good diagnostic efficacy (P < 0.05). Conclusion: The levels of serum Cys-C, urinary UMA and urinary trfu in DN patients were significantly increased, and showed an upward trend with the disease stage, and the diagnostic efficiency was high.