黄连温胆汤治疗冠心病稳定型心绞痛的研究进展
Research Progress on the Treatment of Stable Angina Pectoris of Coronary Heart Disease with Huanglian Wendan Decoction
DOI: 10.12677/acm.2025.1592636, PDF,   
作者: 秦溪悦:黑龙江中医药大学研究生院,黑龙江 哈尔滨;邹国良*:黑龙江中医药大学附属第一医院心血管病科,黑龙江 哈尔滨
关键词: 黄连温胆汤冠心病稳定型心绞痛Huanglian Wendan Decoction Coronary Heart Disease Stable Angina Pectoris
摘要: 冠心病稳定型心绞痛作为临床上常见的心血管疾病,其发病率逐年攀升,严重影响人类生命健康。目前现代医学治疗虽能缓解症状,但长期疗效有限且存在一定的不良反应。黄连温胆汤作为中医经典方剂,具有清热燥湿、化痰和中之功,在心血管疾病治疗中展现出独特优势。本文系统梳理黄连温胆汤治疗冠心病稳定型心绞痛的中医理论基础、药理作用、临床应用及作用机制,总结现有研究成果,分析现阶段黄连温胆汤治疗冠心病稳定型心绞痛研究的潜在不足之处,并展望未来研究方向,旨在为黄连温胆汤的临床应用及深入研究提供参考依据,发挥中医药在冠心病稳定型心绞痛防治中的独特价值。
Abstract: Stable angina pectoris of coronary heart disease is a common cardiovascular disease in clinical practice, with its incidence increasing year by year, seriously affecting human life and health. Although modern medical treatment can alleviate symptoms, its long-term efficacy is limited and there are certain adverse reactions. Huanglian Wendan Decoction, as a classic Chinese medicine formula, has the functions of clearing heat and drying dampness, resolving phlegm and regulating the middle. It shows unique advantages in the treatment of cardiovascular diseases. This article systematically reviews the theoretical basis, pharmacological effects, clinical application and mechanism of action of Huanglian Wendan Decoction in the treatment of stable angina pectoris of coronary heart disease, summarizes the existing research results, analyzes the potential shortcomings of the current research on the treatment of stable angina pectoris of coronary heart disease with Huanglian Wendan Decoction, and looks forward to future research directions. The aim is to provide reference basis for the clinical application and in-depth research of Huanglian Wendan Decoction, and to exert the unique value of traditional Chinese medicine in the prevention and treatment of stable angina pectoris of coronary heart disease.
文章引用:秦溪悦, 邹国良. 黄连温胆汤治疗冠心病稳定型心绞痛的研究进展[J]. 临床医学进展, 2025, 15(9): 1390-1398. https://doi.org/10.12677/acm.2025.1592636

参考文献

[1] 刘明波, 何新叶, 杨晓红, 等. 《中国心血管健康与疾病报告2024》要点解读[J]. 实用医学杂志, 2025, 41(14): 2111-2131.
[2] 贾君迪, 鞠建庆, 高铸烨, 等. 冠心病中西医结合核心数据集构建[J/OL]. 中国中西医结合杂志: 1-11.
https://kns.cnki.net/kcms2/article/abstract?v=w3MPIJRjtYHG_ulL9Hw-K6POIHVI_9w0XPPA48SnOsjqAB-0ADyK9gQ40PHAyhUKwhbiCPqdLHqFVlMFF7jkJY1K659D3HlFDFvlPuymmdCnieTFs4gOVKtEccxCCX1MgVfJcn0vdI5dWyxzBBUI26uYVmsQqWjD&uniplatform=NZKPT, 2025-08-10.
[3] 韩艺, 韩宇博, 邹国良, 等. 治未病思想指导下加味黄连温胆汤治疗代谢综合征患者心血管危险因素的临床观察[J/OL]. 中国实验方剂学杂志: 1-11. 2025-08-10.[CrossRef
[4] 叶婷, 李可欣, 陈爱晖. 黄连温胆汤防治湿热型2型糖尿病的研究进展[J]. 现代中西医结合杂志, 2025, 34(6): 859-864.
[5] 张芹, 刘志明, 刘如秀. 基于“阳微阴弦”理论探讨冠心病病机现代生物学内涵[J]. 辽宁中医药大学学报, 2024, 26(8): 35-38.
[6] 黄礼杨, 候高飞, 潘铨, 等. 畲药逐瘀温胆汤治疗稳定型心绞痛的临床观察[J]. 中国冶金工业医学杂志, 2025, 42(4): 379-381.
[7] 张风丽, 范琳琳, 李寒, 等. 《六因条辨》之黄连温胆汤临床运用浅析[J]. 湖南中医杂志, 2018, 34(11): 106-107.
[8] 关佳怡, 乔明亮, 赵晨怡, 等. 黄连温胆汤现代临床应用及作用机制研究进展[J/OL]. 中华中医药学刊: 1-12.
https://link.cnki.net/urlid/21.1546.R.20250522.1506.048, 2025-08-10.
[9] 李珊珊, 张恒. 黄连温胆汤加减治疗冠心病慢性稳定型心绞痛59例[J]. 河南中医, 2025, 45(8): 1258-1262.
[10] 殷鹏东, 金广炜, 李生龙, 等. 中医药调控NF-κB信号通路治疗CP/CPPS的研究进展[J/OL]. 中国实验方剂学杂志: 1-21. 2025-08-10.[CrossRef
[11] Li, D., Feng, G., Li, Y., Pan, H., Luo, P., Liu, B., et al. (2023) Benefits of Huang Lian Mediated by Gut Microbiota on HFD/STZ-Induced Type 2 Diabetes Mellitus in Mice. Frontiers in Endocrinology, 14, Article 1120221. [Google Scholar] [CrossRef] [PubMed]
[12] Khan, Z., Nath, N., Rauf, A., Emran, T.B., Mitra, S., Islam, F., et al. (2022) Multifunctional Roles and Pharmacological Potential of β-Sitosterol: Emerging Evidence toward Clinical Applications. Chemico-Biological Interactions, 365, Article ID: 110117. [Google Scholar] [CrossRef] [PubMed]
[13] 高满军, 赵宝清, 莫启贵, 等. 茯苓的化学成分及其调节糖脂代谢的研究进展[J]. 湖北科技学院学报(医学版), 2023, 37(3): 272-276.
[14] Wang, Y., Zhang, X., Zhou, C., Khan, H., Fu, M. and Cheang, W.S. (2022) Citri Reticulatae Pericarpium (Chenpi) Protects against Endothelial Dysfunction and Vascular Inflammation in Diabetic Rats. Nutrients, 14, Article 5221. [Google Scholar] [CrossRef] [PubMed]
[15] Li, Y., Wang, X., Chen, H., Yuan, J., Meng, Y. and Yang, W. (2021) Comparison of the Chemical Constituents of Raw Fructus Aurantii and Fructus Aurantii Stir-Baked with Bran, and the Biological Effects of Auraptene. Journal of Ethnopharmacology, 269, Article ID: 113721. [Google Scholar] [CrossRef] [PubMed]
[16] 黄菊青, 齐睿婷, 张英. 竹茹多糖的化学结构及体外免疫活性研究[J]. 中国食品学报, 2017, 17(7): 34-40.
[17] 朱金华, 周军, 万红娇, 等. 黄连温胆汤对2型糖尿病模型大鼠细胞因子及TLR4、NF-κB变化的影响[J]. 中药药理与临床, 2021, 37(3): 6-11.
[18] Wang, D., Wang, P., Zhang, R. and Xi, X. (2020) Efficacy and Safety of Xuefu Zhuyu Decoction Combined with Western Medicine for Angina Pectoris in Coronary Heart Disease: A Protocol for Systematic Review and Meta-Analysis. Medicine, 99, e23195. [Google Scholar] [CrossRef] [PubMed]
[19] Thorwald, M.A., Godoy-Lugo, J.A., Rodriguez, R., Stanhope, K.L., Graham, J.L., Havel, P.J., et al. (2022) Cardiac NF-κB Acetylation Increases While NRF2-Related Gene Expression and Mitochondrial Activity Are Impaired during the Progression of Diabetes in UCD-T2DM Rats. Antioxidants, 11, Article 927. [Google Scholar] [CrossRef] [PubMed]
[20] Chen, X., Chen, C. and Fu, X. (2023) Dendrobium officinale Polysaccharide Alleviates Type 2 Diabetes Mellitus by Restoring Gut Microbiota and Repairing Intestinal Barrier via the LPS/TLR4/TRIF/NF-κB Axis. Journal of Agricultural and Food Chemistry, 71, 11929-11940. [Google Scholar] [CrossRef] [PubMed]
[21] 王立娜, 雷警输, 李奎宝, 等. 急性心肌梗死患者炎症反应研究进展[J/OL]. 中国全科医学, 1-12.
https://link.cnki.net/urlid/13.1222.R.20250901.0855.002, 2025-09-15.
[22] 冼峰, 陈栋. 黄连温胆汤辅助治疗对代谢综合征患者氧化应激反应的影响[J]. 内蒙古中医药, 2021, 40(7): 70-72.
[23] 李雨庭. 黄连温胆汤中黄连最佳剂量对T2DM大鼠肝脏脂代谢PPARα-LXRα-ABCA1信号通路的影响[D]: [博士学位论文]. 哈尔滨: 黑龙江中医药大学, 2018.
[24] 周振龙, 段禹, 沙红玉, 等. 中医药干预心血管细胞凋亡治疗冠心病的研究进展[J/OL]. 中国实验方剂学杂志, 1-16. 2025-09-15.[CrossRef
[25] 钱小情, 周继旺, 李诗国, 等. 黄连温胆汤对痰热互结证2型糖尿病合并非酒精性脂肪肝患者血糖、血脂指标影响[J]. 辽宁中医杂志, 2023, 50(9): 155-159.
[26] 缪美琪, 韩宇博, 刘莉. 黄连温胆汤防治代谢综合征研究进展[J]. 辽宁中医药大学学报, 2023, 25(8): 35-39.
[27] Wang, J., Wang, L., Lou, G., Zeng, H., Hu, J., Huang, Q., et al. (2019) Coptidis rhizoma: A Comprehensive Review of Its Traditional Uses, Botany, Phytochemistry, Pharmacology and Toxicology. Pharmaceutical Biology, 57, 193-225. [Google Scholar] [CrossRef] [PubMed]
[28] 张岩, 李广松, 杨蕊琳. 血府逐瘀汤联合氯吡格雷治疗老年冠心病的效果及对生存质量的影响研究[J]. 中国全科医学, 2021, 24(S1): 169-171.
[29] 王晓楠, 韩宇博, 邹国良, 等. 加味黄连温胆汤治疗痰瘀互结型代谢综合征疗效及对尿酸的影响[J]. 现代中西医结合杂志, 2022, 31(17): 2342-2347.