代谢稳态在早发性卵巢功能不全中的作用及相关干预措施研究进展
The Role of Metabolic Homeostasis in Premature Ovarian Insufficiency and Related Treatment Measures
摘要: 早发性卵巢功能不全(Premature Ovarian Insufficiency, POI)指女性在40岁以前出现卵巢功能减退，严重影响患者的身心健康和生育能力。颗粒细胞及卵母细胞的糖类、脂质及氨基酸的代谢紊乱在POI的发病中具有重要作用。本文综述了糖类、脂质及氨基酸的代谢在维持正常卵巢功能中的作用并讨论了代谢异常对卵巢储备功能的影响以及基于代谢重塑的相关药物或潜在分子对卵巢功能的调控机制。
Abstract: Premature ovarian insufficiency (POI) is defined by loss of normal ovarian function before the age of 40 years, which can severely affect the physical and mental health of women. The metabolism of carbohydrates, amino acids, and lipids in oocytes and granulosa cells plays a significant role in the pathogenesis of POI. This review article provides a summary of glucose metabolism, amino acid and lipid metabolism in maintaining ovarian normal physiological function and homeostasis, the potential impact of metabolic disorder on ovarian reserve and the regulatory mechanisms in repair of ovarian function based on metabolic remodeling.
文章引用：范静雯, 吴瑞瑾. 代谢稳态在早发性卵巢功能不全中的作用及相关干预措施研究进展[J]. 临床医学进展, 2025, 15(9): 1406-1412. https://doi.org/10.12677/acm.2025.1592638

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