深度学习在正畸诊断和治疗中的应用进展
Advances in the Application of Deep Learning for Orthodontic Diagnosis and Treatment
DOI: 10.12677/acm.2025.1592658, PDF,   
作者: 李笙银, 周建萍*:重庆医科大学附属口腔医院正畸科,口腔疾病研究重庆市重点实验室,口腔生物医学工程重庆市高校市级重点实验,重庆市卫生健康委口腔生物医学工程重点实验室,重庆
关键词: 深度学习人工智能正畸学神经网络诊断Deep Learning Artificial Intelligence Orthodontic Neural Network Diagnosis
摘要: 深度学习作为人工智能的重要分支,通过模拟人脑神经元工作机制处理复杂任务,近年来已成为口腔正畸领域精准医疗的关键技术。本文系统评述深度学习在正畸诊疗中的研究进展:在诊断环节,基于头影测量片、全景片及锥形束计算机断层扫描(CBCT)的深度学习技术,可实现颅面标志点自动识别、牙齿分割编号、三维结构分割及发育异常检测,显著提升分析效率并降低人工误差;在治疗规划中,该技术通过预测牙齿移动轨迹、辅助拔牙决策、生成个性化矫治方案及模拟正颌手术过程,为临床决策提供重要支持。当前临床应用仍面临数据来源单一、标注标准差异、模型可解释性不足及多中心泛化能力有限等挑战。未来需构建标准化多中心数据集、开发可解释性模型并优化临床系统集成,推动技术深度融入诊疗全流程。本综述介绍了深度学习技术在口腔正畸领域的应用现状,以增进读者了解。
Abstract: Deep learning, a vital branch of artificial intelligence, processes complex tasks by simulating the working mechanisms of neurons in the human brain. In recent years, it has become a key technology for precision medicine in orthodontics. This review systematically examines research advances in deep learning for orthodontic diagnosis and treatment. In diagnosis, deep learning techniques based on cephalometric radiographs, panoramic radiographs, and cone-beam computed tomography (CBCT) enable automated identification of craniofacial landmarks, tooth segmentation and numbering, 3D structural segmentation, and developmental anomaly detection, significantly improving analysis efficiency while reducing manual errors. For treatment planning, these techniques provide crucial decision support by predicting tooth movement trajectories, assisting in extraction decisions, generating personalized treatment plans, and simulating orthognathic surgical procedures. Current clinical applications still face challenges including limited data sources, inconsistent annotation standards, insufficient model interpretability, and restricted multi-center generalization capability. Future efforts should focus on establishing standardized multi-center datasets, developing interpretable models, and optimizing clinical system integration to facilitate deeper incorporation of the technology into the entire diagnostic and therapeutic workflow. This review presents the current applications of deep learning in orthodontics to enhance reader comprehension.
文章引用:李笙银, 周建萍. 深度学习在正畸诊断和治疗中的应用进展[J]. 临床医学进展, 2025, 15(9): 1577-1585. https://doi.org/10.12677/acm.2025.1592658

参考文献

[1] Nordblom, N.F., Büttner, M. and Schwendicke, F. (2024) Artificial Intelligence in Orthodontics: Critical Review. Journal of Dental Research, 103, 577-584. [Google Scholar] [CrossRef] [PubMed]
[2] LeCun, Y., Bengio, Y. and Hinton, G. (2015) Deep Learning. Nature, 521, 436-444. [Google Scholar] [CrossRef] [PubMed]
[3] Jiao, Z., Liang, Z., Liao, Q., Chen, S., Yang, H., Hong, G., et al. (2024) Deep Learning for Automatic Detection of Cephalometric Landmarks on Lateral Cephalometric Radiographs Using the Mask Region-Based Convolutional Neural Network: A Pilot Study. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 137, 554-562. [Google Scholar] [CrossRef] [PubMed]
[4] Lee, J., Yu, H., Kim, M., Kim, J. and Choi, J. (2020) Automated Cephalometric Landmark Detection with Confidence Regions Using Bayesian Convolutional Neural Networks. BMC Oral Health, 20, Article No. 270. [Google Scholar] [CrossRef] [PubMed]
[5] Lahoud, P., Diels, S., Niclaes, L., Van Aelst, S., Willems, H., Van Gerven, A., et al. (2022) Development and Validation of a Novel Artificial Intelligence Driven Tool for Accurate Mandibular Canal Segmentation on CBCT. Journal of Dentistry, 116, Article ID: 103891. [Google Scholar] [CrossRef] [PubMed]
[6] Köktürk, B., Pamukçu, H. and Gözüaçık, Ö. (2024) Evaluation of Different Machine Learning Algorithms for Extraction Decision in Orthodontic Treatment. Orthodontics & Craniofacial Research, 27, 13-24. [Google Scholar] [CrossRef] [PubMed]
[7] Gao, F. and Tang, Y. (2025) Multimodal Deep Learning for Cephalometric Landmark Detection and Treatment Prediction. Scientific Reports, 15, Article No. 25205. [Google Scholar] [CrossRef] [PubMed]
[8] 马建斌, 薛超然, 白丁. 人工智能技术在口腔正畸诊疗中的应用研究进展[J]. 口腔疾病防治, 2022, 30(4): 278-282.
[9] Tjoa, E. and Guan, C. (2021) A Survey on Explainable Artificial Intelligence (XAI): Toward Medical XAI. IEEE Transactions on Neural Networks and Learning Systems, 32, 4793-4813. [Google Scholar] [CrossRef] [PubMed]
[10] Schmidhuber, J. (2015) Deep Learning in Neural Networks: An Overview. Neural Networks, 61, 85-117. [Google Scholar] [CrossRef] [PubMed]
[11] Hinton, G.E., Osindero, S. and Teh, Y. (2006) A Fast Learning Algorithm for Deep Belief Nets. Neural Computation, 18, 1527-1554. [Google Scholar] [CrossRef] [PubMed]
[12] Krizhevsky, A., Sutskever, I. and Hinton, G.E. (2017) Imagenet Classification with Deep Convolutional Neural Networks. Communications of the ACM, 60, 84-90. [Google Scholar] [CrossRef
[13] Woo, S., Park, J., Lee, J. and Kweon, I.S. (2018) CBAM: Convolutional Block Attention Module. Computer Vision-ECCV 2018: 15th European Conference, Munich, 8-14 September 2018, 3-19. [Google Scholar] [CrossRef
[14] Schwendicke, F., Chaurasia, A., Arsiwala, L., Lee, J., Elhennawy, K., Jost-Brinkmann, P., et al. (2021) Deep Learning for Cephalometric Landmark Detection: Systematic Review and Meta-Analysis. Clinical Oral Investigations, 25, 4299-4309. [Google Scholar] [CrossRef] [PubMed]
[15] Yang, S., Song, E.S., Lee, E.S., Kang, S., Yi, W. and Lee, S. (2023) Ceph-net: Automatic Detection of Cephalometric Landmarks on Scanned Lateral Cephalograms from Children and Adolescents Using an Attention-Based Stacked Regression Network. BMC Oral Health, 23, Article No. 803. [Google Scholar] [CrossRef] [PubMed]
[16] Sadr, S., Mohammad-Rahimi, H., Ghorbanimehr, M.S., Rokhshad, R., Abbasi, Z., Soltani, P., et al. (2023) Deep Learning for Tooth Identification and Enumeration in Panoramic Radiographs. Dental Research Journal, 20, Article No. 116. [Google Scholar] [CrossRef
[17] Dot, G., Chaurasia, A., Dubois, G., Savoldelli, C., Haghighat, S., Azimian, S., et al. (2024) Dentalsegmentator: Robust Open Source Deep Learning-Based CT and CBCT Image Segmentation. Journal of Dentistry, 147, Article ID: 105130. [Google Scholar] [CrossRef] [PubMed]
[18] Milletari, F., Navab, N. and Ahmadi, S. (2016) V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation. 2016 4th International Conference on 3D Vision (3DV), Stanford, 25-28 October 2016, 565-571. [Google Scholar] [CrossRef
[19] Liu, J., Zhang, C. and Shan, Z. (2023) Application of Artificial Intelligence in Orthodontics: Current State and Future Perspectives. Healthcare, 11, Article No. 2760. [Google Scholar] [CrossRef] [PubMed]
[20] Brückner, C., Liu, C., Rist, L. and Maier, A. (2024) Influence of Imperfect Annotations on Deep Learning Segmentation Models. In: Maier, A., et al., Eds., Bildverarbeitung für die Medizin 2024, Springer, 226-231. [Google Scholar] [CrossRef
[21] Le, V.N.T., Kang, J., Oh, I., Kim, J., Yang, Y. and Lee, D. (2022) Effectiveness of Human-Artificial Intelligence Collaboration in Cephalometric Landmark Detection. Journal of Personalized Medicine, 12, Article No. 387. [Google Scholar] [CrossRef] [PubMed]
[22] 吴玥, 严斌. 机器学习在口腔正畸学领域的应用[J]. 口腔医学, 2022, 42(1): 29-35.
[23] 曹凌云, 颜家榕, 汤博钧. 深度学习在头影测量中的应用研究进展[J]. 口腔疾病防治, 2023, 31(1): 58-62.
[24] Putra, R.H., Astuti, E.R., Nurrachman, A.S., Putri, D.K., Ghazali, A.B., Pradini, T.A., et al. (2023) Convolutional Neural Networks for Automated Tooth Numbering on Panoramic Radiographs: A Scoping Review. Imaging Science in Dentistry, 53, 271-281. [Google Scholar] [CrossRef] [PubMed]
[25] Liu, J., Hu, T., Feng, Y., Ding, W. and Liu, Z. (2023) Toothsegnet: Image Degradation Meets Tooth Segmentation in CBCT Images. 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), Cartagena, 18-21 April 2023, 1-5. [Google Scholar] [CrossRef
[26] Sinard, E., Gajny, L., de La Dure‐Molla, M., Felizardo, R. and Dot, G. (2025) Automated Cone Beam Computed Tomography Segmentation of Multiple Impacted Teeth with or without Association to Rare Diseases: Evaluation of Four Deep Learning‐Based Methods. Orthodontics & Craniofacial Research, 28, 433-440. [Google Scholar] [CrossRef] [PubMed]
[27] Milani, O.H., Atici, S.F., Allareddy, V., Ramachandran, V., Ansari, R., Cetin, A.E., et al. (2024) A Fully Automated Classification of Third Molar Development Stages Using Deep Learning. Scientific Reports, 14, Article No. 13082. [Google Scholar] [CrossRef] [PubMed]
[28] Xu, S., Peng, H., Yang, L., Zhong, W. and Gao, X. (2025) Automatic Detection of Orthodontically Induced External Root Resorption Based on Deep Convolutional Neural Networks Using CBCT Images. Scientific Reports, 15, Article No. 22984. [Google Scholar] [CrossRef] [PubMed]
[29] Dong, Z., Chen, J. and Xu, Y. (2024) Transformer-Based Tooth Alignment Prediction with Occlusion and Collision Constraints.
[30] Liu, J., Hao, J., Lin, H., Pan, W., Yang, J., Feng, Y., et al. (2023) Deep Learning-Enabled 3D Multimodal Fusion of Cone-Beam CT and Intraoral Mesh Scans for Clinically Applicable Tooth-Bone Reconstruction. Patterns, 4, Article ID: 100825. [Google Scholar] [CrossRef] [PubMed]
[31] Shojaei, H. and Augusto, V. (2022) Constructing Machine Learning Models for Orthodontic Treatment Planning: A Comparison of Different Methods. 2022 IEEE International Conference on Big Data (Big Data), Osaka, 17-20 December 2022, 2790-2799. [Google Scholar] [CrossRef
[32] Huang, J., Chan, I., Wang, Z., Ding, X., Jin, Y., Yang, C., et al. (2024) Evaluation of Four Machine Learning Methods in Predicting Orthodontic Extraction Decision from Clinical Examination Data and Analysis of Feature Contribution. Frontiers in Bioengineering and Biotechnology, 12, Article ID: 1483230. [Google Scholar] [CrossRef] [PubMed]
[33] Ingle, N.A., Alabsi, N.F., Al-Hashimi, H., Albuolayan, N.A., Alburidy, F., Alanazi, F., et al. (2025) The Use of Artificial Intelligence in Orthodontic Treatment Planning: A Systematic Review and Meta-Analysis. Advances in Human Biology, 15, 158-166. [Google Scholar] [CrossRef
[34] Wolf, D., Farrag, G., Flügge, T. and Timm, L.H. (2024) Predicting Outcome in Clear Aligner Treatment: A Machine Learning Analysis. Journal of Clinical Medicine, 13, Article No. 3672. [Google Scholar] [CrossRef] [PubMed]
[35] Gracea, R.S., Winderickx, N., Vanheers, M., Hendrickx, J., Preda, F., Shujaat, S., et al. (2025) Artificial Intelligence for Orthodontic Diagnosis and Treatment Planning: A Scoping Review. Journal of Dentistry, 152, Article ID: 105442. [Google Scholar] [CrossRef] [PubMed]
[36] 杨振泽, 林军. 人工智能在正畸正颌联合治疗的应用及展望[J]. 口腔医学, 2023, 43(8): 747-751.
[37] Li, Z. and Wang, L. (2025) Multi-task Reinforcement Learning and Explainable AI-Driven Platform for Personalized Planning and Clinical Decision Support in Orthodontic-Orthognathic Treatment. Scientific Reports, 15, Article No. 24502. [Google Scholar] [CrossRef] [PubMed]
[38] Jeong, S.H., Yun, J.P., Yeom, H., Lim, H.J., Lee, J. and Kim, B.C. (2020) Deep Learning Based Discrimination of Soft Tissue Profiles Requiring Orthognathic Surgery by Facial Photographs. Scientific Reports, 10, Article No. 16235. [Google Scholar] [CrossRef] [PubMed]
[39] Serafin, M., Baldini, B., Cabitza, F., Carrafiello, G., Baselli, G., Del Fabbro, M., et al. (2023) Accuracy of Automated 3D Cephalometric Landmarks by Deep Learning Algorithms: Systematic Review and Meta-Analysis. La Radiologia Medica, 128, 544-555. [Google Scholar] [CrossRef] [PubMed]
[40] Naik, N., Hameed, B.M.Z., Shetty, D.K., Swain, D., Shah, M., Paul, R., et al. (2022) Legal and Ethical Consideration in Artificial Intelligence in Healthcare: Who Takes Responsibility? Frontiers in Surgery, 9, Article ID: 862322. [Google Scholar] [CrossRef] [PubMed]
[41] Kaissis, G.A., Makowski, M.R., Rückert, D. and Braren, R.F. (2020) Secure, Privacy-Preserving and Federated Machine Learning in Medical Imaging. Nature Machine Intelligence, 2, 305-311. [Google Scholar] [CrossRef
[42] Cui, L. and Wu, X. (2025) ALDP-FL for Adaptive Local Differential Privacy in Federated Learning. Scientific Reports, 15, Article No. 26679. [Google Scholar] [CrossRef] [PubMed]
[43] Price, W.N. and Cohen, I.G. (2019) Privacy in the Age of Medical Big Data. Nature Medicine, 25, 37-43. [Google Scholar] [CrossRef] [PubMed]
[44] Braun, M., Hummel, P., Beck, S. and Dabrock, P. (2020) Primer on an Ethics of AI-Based Decision Support Systems in the Clinic. Journal of Medical Ethics, 47, e3. [Google Scholar] [CrossRef] [PubMed]
[45] Topol, E.J. (2019) High-Performance Medicine: The Convergence of Human and Artificial Intelligence. Nature Medicine, 25, 44-56. [Google Scholar] [CrossRef] [PubMed]
[46] He, J., Baxter, S.L., Xu, J., Xu, J., Zhou, X. and Zhang, K. (2019) The Practical Implementation of Artificial Intelligence Technologies in Medicine. Nature Medicine, 25, 30-36. [Google Scholar] [CrossRef] [PubMed]