心肌致密化不全心肌病患者预后影响因素分析

Analysis of Factors Affecting Prognosis in Patients with Myocardial Densification Insufficiency Cardiomyopathy

摘要: 目的：探讨心肌致密化不全心肌病(NVM)患者的临床特征及其预后相关因素。方法：回顾性分析近10年新疆医科大学第一附属医院确诊的120例NVM患者的临床与随访资料，采用Kaplan-Meier方法分析生存情况，COX回归模型评估影响死亡的独立预测因素。结果：随访期间总死亡率为26.67%。多因素COX回归分析显示，左心房容积指数(LAVI)和左室舒张末期内径(LVEDD)为全因死亡的独立预测因子(P < 0.05)。Kaplan-Meier分析进一步证实，LAVI > 21.89 ml/m²与LVEDD > 55 mm患者生存率显著下降。结论：LAVI与LVEDD可作为NVM患者预后判断的重要参数，早期识别并干预有助于改善其预后。

Abstract: Objective: To explore the clinical characteristics and prognostic factors in patients with non-compaction cardiomyopathy (NVM). Methods: A retrospective analysis was conducted on the clinical and follow-up data of 120 patients diagnosed with NVM at the First Affiliated Hospital of Xinjiang Medical University over the past ten years. Kaplan-Meier survival analysis was used to evaluate overall survival, and Cox regression models were applied to identify independent predictors of mortality. Results: The overall mortality rate during follow-up was 26.67%. Multivariate Cox regression analysis identified left atrial volume index (LAVI) and left ventricular end-diastolic diameter (LVEDD) as independent predictors of all-cause mortality (P < 0.05). Kaplan-Meier analysis further confirmed that patients with LAVI > 21.89 ml/m² and LVEDD > 55 mm had significantly lower survival rates. Conclusion: LAVI and LVEDD are important prognostic indicators for patients with NVM. Early identification and timely intervention may help improve prognosis.