慢性萎缩性胃炎伴肠上皮化生进展的影响因素
A Systematic Review of Influencing Factors of Progression of Chronic Atrophic Gastritis with Intestinal Epithelial Hyperplasia
DOI: 10.12677/acm.2025.1592672, PDF,   
作者: 王新琦：延安大学医学院，陕西 延安；郝婷婷*：延安大学附属医院消化内科，陕西 延安
关键词: 慢性萎缩性胃炎；肠上皮化生；Chronic Atrophic Gastritis； Intestinal Metaplasia
摘要: 胃黏膜肠化生是指正常胃上皮细胞和胃腺组织向肠上皮细胞及肠腺转化的病理过程，胃柱状细胞被肠道形态的细胞替代，其特征是存在含黏蛋白的杯状细胞、Paneth细胞和吸收细胞，导致胃黏膜上皮正常，周围腺体被肠上皮和腺体替代被认为是胃癌的重要前驱病变。综合分析导致慢性萎缩性胃炎伴肠上皮化生进展的影响因素有：幽门螺杆菌感染、胆汁反流、吸烟及饮酒、家族史、肥胖、A型血、高龄、糖尿病等。本文就国内外慢性萎缩性胃炎伴肠上皮化生进展的影响因素作一系统综述，探讨慢性萎缩性胃炎伴肠上皮化生进展的相关因素，为采取有效的预防措施采取科学依据，旨在为胃癌的一级预防和卫生决策提供科学依据。
Abstract: Gastric mucosal intestinal metaplasia refers to the pathological process where normal gastric epithelial cells and gastric gland tissues transform into intestinal epithelial cells and intestinal glands. The columnar cells of the stomach are replaced by cells with intestinal morphology. Its characteristics include the presence of mucin-containing goblet cells, Paneth cells, and absorptive cells, resulting in normal gastric mucosal epithelium and the replacement of surrounding glands with intestinal epithelium and glands, which is considered an important precursor lesion of gastric cancer. Comprehensive analysis of the influencing factors leading to the progression of chronic atrophic gastritis with intestinal metaplasia reveals: Helicobacter pylori infection, bile reflux, smoking and drinking, family history, obesity, A-type blood, old age, diabetes, etc. This article presents a systematic review of the influencing factors of chronic atrophic gastritis with intestinal metaplasia at home and abroad, explores the related factors of the progression of chronic atrophic gastritis with intestinal metaplasia, and provides scientific basis for taking effective preventive measures, aiming to provide scientific basis for the primary prevention of gastric cancer and health decision-making.
文章引用：王新琦, 郝婷婷. 慢性萎缩性胃炎伴肠上皮化生进展的影响因素[J]. 临床医学进展, 2025, 15(9): 1697-1702. https://doi.org/10.12677/acm.2025.1592672

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