胆红素超分子纳米药物的构建及其性能研究
Construction and Property Research of Bilirubin Supramolecular Nanomedicine
DOI: 10.12677/jocr.2025.133031, PDF,    科研立项经费支持
作者: 程苏灿, 田艳雯, 左心怡, 张宜鑫, 丁 月*：南通大学化学化工学院，江苏 南通；陆钰嫄：南通大学医学院，江苏 南通
关键词: 药物递送；胆红素；光热疗法；主客体作用；超分子纳米前药；Drug Delivery； Bilirubin； Photothermal Therapy； Host-Guest Interactions； Supramolecular Nanoprodrug
摘要: 我们设计制备了一种胆红素(BR)超分子纳米药物SNBR/DOX，它是由阴离子水溶性联苯拓展型柱[6]芳烃(AWBpP6)、吡啶末端修饰的聚赖氨酸–胆红素共轭物(PBR)基于主客体识别作用，并包封阿霉素(DOX)构建而成。该胆红素超分子纳米药物具有较强的清除氧气和活性氧的能力，在氧气和活性氧的作用下，疏水性的胆红素可转变为亲水性的胆绿素(BV)，从而使超分子纳米药物发生解组装，释放出化疗药物阿霉素，实现化疗(CT)。同时，在808 nm的近红外光照射下，生成的胆绿素能够将近红外光转换为热能，实现光热治疗(PTT)。
Abstract: We designed and prepared a bilirubin (BR) supramolecular nanomedicine, SNBR/DOX, which was constructed by anionic watersoluble [2]biphenyl-extended-pillar [6]arenes (AWBpP6), pyridinium-terminal-modified polylysine-bilirubin conjugate (PBR), and encapsulated doxorubicin (DOX) based on host-guest interactions. Owing to the strong capability to scavenge oxygen and reactive oxygen species, the hydrophobic BR could be transformed into hydrophilic biliverdin (BV) under the action of oxygen and reactive oxygen species. The transformation from BR to BV induced the disassembly of supramolecular nanoprodrug to release chemotherapy drug DOX to realize chemotherapy (CT). Meanwhile, upon irradiation with 808 nm near-infrared light, BV could absorb near-infrared light for conversion into heat energy to realize photothermal therapy (PTT).
文章引用：程苏灿, 陆钰嫄, 田艳雯, 左心怡, 张宜鑫, 丁月. 胆红素超分子纳米药物的构建及其性能研究[J]. 有机化学研究, 2025, 13(3): 311-318. https://doi.org/10.12677/jocr.2025.133031

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