幽门螺旋杆菌与高血压的联系及其机制的研究进展

Research Progress on the Relationship and Mechanism between Helicobacter pylori and Hypertension

摘要: 幽门螺旋杆菌是一种定植于胃中微需氧的革兰阴性杆菌，近年来的研究发现其可能与高血压的发生发展存在关联，本文现就幽门螺旋杆菌与高血压流行病学联系的最新证据，探讨了可能的发病机制，包括慢性炎症反应、肠道菌群失调以及代谢异常、胃肠黏膜的损伤与营养吸收障碍、高渗环境、维生素D代谢等方面，同时总结了相关临床研究进展和治疗意义，并对未来研究方向提出了展望，为深入理解幽门螺旋杆菌感染与高血压的关系提供了重要参考。

Abstract: Helicobacter pylori is a Gram-negative, microaerophilic bacterium that persistently colonizes the gastric mucosa. Accumulating evidence suggests its potential involvement in the pathogenesis and progression of hypertension. This review systematically evaluates current epidemiological evidence supporting the association between H. pylori infection and hypertension, while delineating potential mechanistic pathways, such as: Chronic low-grade inflammation, Gut microbiota dysbiosis and metabolic dysfunction, Gastrointestinal mucosal damage leading to impaired nutrient absorption, Induction of a hypertonic state, Disrupted vitamin D metabolism. Additionally, we synthesize recent advances in clinical research and highlight therapeutic implications. Finally, we propose future research directions to further elucidate the causal relationship between H. pylori infection and hypertension, offering valuable insights for both basic research and clinical practice.