LINC01094在胃腺癌组织学分级及组织学种类中的研究进展

Research Progress of LINC01094 in Histological Grading and Histological Types of Gastric Adenocarcinoma

摘要: 近年来，长链非编码RNA LINC01094被证实参与多种恶性肿瘤的病理进程，尤其在胃腺癌领域备受研究者关注。作为临床预后较差的消化道肿瘤，胃腺癌的病理学特征对治疗方案制定和预后判断具有重要指导价值。然而，关于该分子在不同病理分级及亚型中的表达差异及其作用机制，目前尚未形成明确结论。本综述系统分析了LINC01094在胃腺癌组织中的表达谱特征，重点探讨了其与肿瘤分化程度、组织学分型的相关性。研究发现，该分子可能通过介导多条信号转导途径促进肿瘤发展，这为开发新型诊断标志物和分子靶向干预策略提供了理论依据。

Abstract: In recent years, long-chain non-coding RNA LINC01094 has been confirmed to be involved in the pathological processes of various malignant tumors, especially in the field of gastric adenocarcinoma, which has attracted much attention from researchers. As a gastrointestinal tumor with poor clinical prognosis, the pathological characteristics of gastric adenocarcinoma have important guiding value for the formulation of treatment plans and prognosis judgment. However, there is no clear conclusion on the expression differences of this molecule in different pathological grades and subtypes and its mechanism of action. This review systematically analyzes the expression profile characteristics of LINC01094 in gastric adenocarcinoma tissues, focusing on its correlation with tumor differentiation and histological typing. The study found that this molecule may promote tumor development by mediating multiple signal transduction pathways, which provides a theoretical basis for the development of new diagnostic markers and molecular targeted intervention strategies.