瑞马唑仑在无痛气管镜中的GABAA受体作用机制及其临床优势
The Mechanism of Action of Remimazolam on GABAA Receptors in Painless Bronchoscopy and Its Clinical Advantages
DOI: 10.12677/acm.2025.15102737, PDF,    科研立项经费支持
作者: 张 琪*:绍兴文理学院医学院,浙江 绍兴;陈忠华#:绍兴市人民医院麻醉科,浙江 绍兴
关键词: 瑞马唑仑无痛气管镜GABAA受体Remimazolam Painless Bronchoscopy GABAA Receptor
摘要: 由于社会发展以及医疗舒适化,无痛气管镜检查已成为呼吸系统疾病诊断和治疗的常用方法。瑞马唑仑作为一种新型超短效镇静药物,凭借其快速起效、迅速恢复、不良反应少等药理学特性,展现出其在无痛气管镜中较高的成功率、呼吸循环的稳定性、苏醒质量以及术后认知功能恢复等方面的优势。本文综述了瑞马唑仑在无痛气管镜中的GABAA受体作用机制及其临床应用优势,未来随着联合用药方案的优化,瑞马唑仑有望进一步推动气管镜镇静进入智能化、个体化时代。
Abstract: Due to societal development and the trend toward patient comfort in medical care, pain-free bronchoscopy has become a commonly used method for the diagnosis and treatment of respiratory system diseases. Remimazolam, as a novel ultra-short-acting sedative drug, demonstrates its advantages in pain-free bronchoscopy due to its pharmacological characteristics, including rapid onset of action, swift recovery, and minimal adverse effects. These characteristics contribute to its high success rate, stability of respiratory and circulatory functions, quality of awakening, and improved post-operative cognitive function recovery. This article reviews the GABAA receptor mechanism of action of remimazolam in pain-free bronchoscopy and its clinical application advantages. In the future, with the optimization of combination therapy regimens, remimazolam is expected to further drive the advancement of bronchoscopy sedation into an era of intelligence and individualization.
文章引用:张琪, 陈忠华. 瑞马唑仑在无痛气管镜中的GABAA受体作用机制及其临床优势[J]. 临床医学进展, 2025, 15(10): 140-149. https://doi.org/10.12677/acm.2025.15102737

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