肾透明细胞癌新型分子标志物的研究进展:从CD24到NCAPG的预后价值
Research Progress on Novel Molecular Markers for Clear Cell Renal Cell Carcinoma: The Prognostic Value from CD24 to NCAPG
DOI: 10.12677/acm.2025.15102768, PDF,   
作者: 陈亦铭*:绍兴文理学院医学院,浙江 绍兴;骆振刚#:绍兴市人民医院泌尿外科,浙江 绍兴
关键词: 肾透明细胞癌CD24NCAPGClear Cell Renal Cell Carcinoma CD24 NCAPG
摘要: 肾透明细胞癌是泌尿系统中最常见的恶性肿瘤,其预后难以预测。本文系统综述了肾透明细胞癌中CD24与NCAPG两种新型分子标志物的预后价值及分子机制。CD24通过糖基化修饰和CD24/Siglec-10轴参与免疫逃逸,其高表达与患者不良预后显著相关。NCAPG通过调控CDK1和PI3K-AKT/mTOR通路促进肿瘤增殖,其过表达也与预后不良密切相关。两者在肾透明细胞癌中呈现共表达模式,并协同调控肿瘤微环境与免疫浸润。文章还探讨了其在液体活检、预后模型构建及靶向治疗中的临床应用潜力与当前局限,为肾透明细胞癌的精准预后评估和个体化治疗提供了新思路。
Abstract: Clear cell renal cell carcinoma is the most common malignant tumor in the urinary system, with a challenging prognosis to predict. This paper systematically reviews the prognostic value and molecular mechanisms of two novel molecular markers, CD24 and NCAPG, in clear cell renal cell carcinoma. CD24 contributes to immune evasion through glycosylation modifications and the CD24/Siglec-10 axis, with its overexpression significantly correlating with poor patient prognosis. NCAPG promotes tumor proliferation by regulating CDK1 and the PI3K-AKT/mTOR pathway, and its overexpression is also closely associated with poor outcomes. Both markers exhibit co-expression patterns in clear cell renal cell carcinoma and synergistically regulate the tumor microenvironment and immune infiltration. The article further explores their clinical application potential and current limitations in liquid biopsy, prognostic model development, and targeted therapy, offering novel insights for precision prognostic assessment and personalized treatment in clear cell renal cell carcinoma.
文章引用:陈亦铭, 骆振刚. 肾透明细胞癌新型分子标志物的研究进展:从CD24到NCAPG的预后价值[J]. 临床医学进展, 2025, 15(10): 386-397. https://doi.org/10.12677/acm.2025.15102768

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