成人颅内生殖细胞瘤1例报告伴文献复习
Intracranial Germ Cell Tumors in Adults: A Case Report and Literature Review
摘要: 目的：探讨颅内生殖细胞肿瘤(Intracranial Germ Cell Tumors, iGCTs)的临床特点、诊断及治疗策略。方法：回顾性分析1例37岁男性松果体生殖细胞瘤(germinoma)患者的临床资料，并结合文献复习总结其诊疗经验。结果：患者因复视伴头晕入院，术后病理确诊生殖细胞瘤，术后接受全脑全脊髓照射治疗(Craniospinal Irradiation, CSI)，肿瘤控制良好。结论：成人颅内生殖细胞肿瘤较为罕见，生殖细胞瘤是其常见的病理类型，对放疗高度敏感，全脑全脊髓照射治疗可取得良好疗效。然而，成人患者最佳放疗范围和剂量尚缺乏统一标准，仍需进一步研究与长期随访。
Abstract: Objective: To investigate the clinical features, diagnosis and treatment strategies of Intracranial Germ Cell Tumors (iGCTs). Methods: We retrospectively analyzed the clinical data of a 37-year-old male patient with a pineal region germinoma and summarized the experience of diagnosis and treatment by reviewing the literature. Results: The patient was admitted to the hospital due to diplopia and dizziness. Postoperative pathology confirmed germinoma. Following craniospinal irradiation, the tumor was well controlled. Conclusions: Adult intracranial germinoma is rare, and germinoma is a common pathological type, highly sensitive to radiotherapy. Craniospinal irradiation achieves excellent local control. Nevertheless, the optimal radiation strategy in adults remains controversial, highlighting the need for individualized treatment and long-term surveillance.
文章引用：应羽霏, 吴东平. 成人颅内生殖细胞瘤1例报告伴文献复习[J]. 临床医学进展, 2025, 15(10): 454-460. https://doi.org/10.12677/acm.2025.15102777

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